Any info on delta F508/c.2657+2_2657+3insA

candi81

New member
Hey, I was reading your post and I have to say..this is the CLOSEST that I've ever seen anyone to my son's mutations. He has DF508/c.2789+2_+3insA. I've been trying to find someone with his second mutation, but so far no luck. I realize that it's not always possible to predict the severity of the disease based on the mutations, but I just wanted to get a sense of how rare his mutation was. My son Andrew was diagnosed through newborn screenings, and just turned 1 a couple weeks ago. So far he is pancreatic sufficient and has had no lung issues.
 

G-STAR

New member
Hi
My daughter has just been diagnosed with this combination. she is now 3 months old and doing well. we are based in Ireland and cannot find information on this gene combination. How are you all doing since? I would be very grateful if you can help me. Hoping you are doing good?
 

rgjbruin

New member
some info, hope this helps...

Hi
My daughter has just been diagnosed with this combination. she is now 3 months old and doing well. we are based in Ireland and cannot find information on this gene combination. How are you all doing since? I would be very grateful if you can help me. Hoping you are doing good?

I'm not sure how these resources would apply to your daughter.

http://www.ncbi.nlm.nih.gov/pubmed/11101688
http://www.ncbi.nlm.nih.gov/pubmed/16189704

http://www.cftr2.org/browse.php
http://www.genet.sickkids.on.ca/cftr/SearchPage.html

Take care and God bless,
Rich
 

oldcfguy

New member
I just found this forum and thought I would give some hope for the folks that have delta F508/c.2657+2_2657+3insA combo. I am 52 years old and living a fairly good life. I was diagnosed at age 50 with genetic testing and a sweat test - 107. I don't really have any respiratory symptoms just all digestive. I now take digestive enzymes which helps a lot to digest foods. My main symptom my whole life had been digestive issues and the CF went undiagnosed since I did not have the classic respiratory symptoms and it was before genetic testing and newborn screening. If you have questions, send me a private message and I will be happy to reply.
 

A B

New member
Hi! I doubt you check this still but in the chance you do, let me introduce myself. My name is Amy and I have two kids with the same mutation as your child. We have started an online Facebook page if you would like to join. It’s just for families with these mutations. If you want to join, find me on Facebook Amy Bergan Ellison or just go to Facebook and search “cystic fibrosis 2789”. Take care!
 
Hi! I doubt you check this still but in the chance you do, let me introduce myself. My name is Amy and I have two kids with the same mutation as your child. We have started an online Facebook page if you would like to join. It’s just for families with these mutations. If you want to join, find me on Facebook Amy Bergan Ellison or just go to Facebook and search “cystic fibrosis 2789”. Take care!

Hello, I just found out my son has these gene mutations yesterday. I would like to ask you some questions!

-Courtney
 

Dwheeler14

New member
Hi! I doubt you check this still but in the chance you do, let me introduce myself. My name is Amy and I have two kids with the same mutation as your child. We have started an online Facebook page if you would like to join. It’s just for families with these mutations. If you want to join, find me on Facebook Amy Bergan Ellison or just go to Facebook and search “cystic fibrosis 2789”. Take care!

Hi Amy!!! I added you as a friend on facebook because I'd love to connect with someone else who deals with these gene mutations. My wife and I are considering a major life move and would love to chat!
 

G-STAR2

New member
some info, hope this helps...



I'm not sure how these resources would apply to your daughter.

http://www.ncbi.nlm.nih.gov/pubmed/11101688
http://www.ncbi.nlm.nih.gov/pubmed/16189704

http://www.cftr2.org/browse.php
http://www.genet.sickkids.on.ca/cftr/SearchPage.html

Take care and God bless,
Rich
Hi, hope you are all doing well. Just to let you know our daughter is now 8 and has had no symptoms or problems so far. Her consultant is keen that she starts taking Trikafta. We are reluctant to start on long term medication, when she has no symptoms. Is anyone else taking Trikafta or have concerns about taking it? Glad of any advice you can provide.
 

Ratatosk

Administrator
Staff member
Hi, hope you are all doing well. Just to let you know our daughter is now 8 and has had no symptoms or problems so far. Her consultant is keen that she starts taking Trikafta. We are reluctant to start on long term medication, when she has no symptoms. Is anyone else taking Trikafta or have concerns about taking it? Glad of any advice you can provide.
The key with CF is to be proactive. To prevent any potential lung damage or other major issues. Prior to the correctors, we did chest physiotherapy 3-4 times a day to keep DS's lungs healthy and clear of any mucus buildup. He also took/takes a handful of medications and vitamins as well. He started orkambi at age 12 and has been on Trikafta for almost 4 years. He no longer struggles to gain weight, his cf cultures have been normal flora for the most part after ALWAY culturing something since he was an infant -- pseudomonas, steno. maltophilia, etc.
 
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