I have a stop codon on one gene and a 5T variant on the other gene. The second gene has polymorphisms but no known disease causing mutation. My doctor is working on the insurance approval now. I have had a 6 month lung function decline, diagnosed with CFRD last week, and culture PA. Any tips or research I can give my doctor to help my cause please share. Anyone on Kalydeco with 5T variant as the only thing decreasing CFTR on that gene?