January Vertex Update- Latest VX809, VX661 and Kalydeco with gating & R117H info

[GenH]

I recently wrote a blog post about the latest Vertex news (includes info from the Dec and Jan press releases & investor conferences). Since I wrote this post it has also been announced that the combination therapy VX661/Ivacaftor has been granted breakthrough FDA designation.

http://sixtyfiverosesblog.wordpress.com/2014/01/29/january-vertex-update/

 

[Gammaw]

Do I understand this to mean there are no trials for 661 with df508 heterozygotes?

 

[GenH]

Do I understand this to mean there are no trials for 661 with df508 heterozygotes?

There is one heterozygote trial for people with F508del and G551D, but I am not aware of any other trials for heterozygotes. On clinicaltrials.gov this is the only VX661 trial: http://www.clinicaltrials.gov/ct2/show/NCT01531673?term=vx661&rank=1