So for the past couple of years right before I start to get sick I experience low grade fevers and ankle and leg swelling. After a couple of days of this my fevers run into the 101-103 range and I'm admitted. I have about a two week break between admissions at this point. My doctors aren't sure what it is because my lab values look normal for any type of infection, but my lab tests for inflammation always come back positive. I've seen a Rheumatologist who ruled out rheumatoid arthritis and has sent me onto an Immunologist who has ruled out any sort of deficiency and has sent me to get a second opinion from another Rheumatologist. The only thing they have treated me with is prednisone and tried backing down on my Orkambi to just one tab twice a day. While the steroids have helped manage the pain and some of the swelling so I am able to move, the change in Orkambi hasn't made a difference. Does anyone else experience this or have any insight to what this might be?