A very interesting and potentially significant study was published by a french group at the Institute Pasteur demonstrating how a bacterium manipulates its host to eradicate an opponent. They showed that a particular enzyme produced by the airways of cystic fibrosis patients is instrumental in the elimination of S. aureus by P. aeruginosa. P. aeruginosa uses the airway’s immune system to kill the S. aureus bacterium.
The scientists have demonstrated the role played in this bacterial contest by an enzyme, type IIA phospholipase A2(sPLA2-IIA), whose ability to kill Gram positive bacteria such as S. aureus was already known. To date, sPLA2-IIA is known as the most powerful antimicrobial peptide produced by humans and able to kill S. aureus.
This opens important treatment possibilities as sPLA2-IIA could be injected into patients infected with Gram positive bacteria, which could be a useful alternative therapy to overcome bacterial resistance to antibiotics.
Read full source: http://t.co/OHuS0ZWuFH
- Chris
The scientists have demonstrated the role played in this bacterial contest by an enzyme, type IIA phospholipase A2(sPLA2-IIA), whose ability to kill Gram positive bacteria such as S. aureus was already known. To date, sPLA2-IIA is known as the most powerful antimicrobial peptide produced by humans and able to kill S. aureus.
This opens important treatment possibilities as sPLA2-IIA could be injected into patients infected with Gram positive bacteria, which could be a useful alternative therapy to overcome bacterial resistance to antibiotics.
Read full source: http://t.co/OHuS0ZWuFH
- Chris