Question for MCGrad re: Aztreonam

D

dasjsmum

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>MCGrad2006</b></i>

Well I have had my eflow for 12 months now, using it for the aztreonam study that I have been in. My PFT's hit the highest they have been in over 6 years last summer after only a few months of using the aztreonam/eflow. My PA count always goes down the month that I am using the drug while also, my coughing and sputum production goes down as well.
END OF QUOTE


Hello

Hope I've been able to successfully make a quote!!??
Anyhow, I was wondering if you could share more about your experience on this thread?
I'm really interested in how you went in the study, and any others out there who have been involved in this study also.

Okay, I wasnt completely successful with the quote part...
 
D

dasjsmum

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>MCGrad2006</b></i>

Well I have had my eflow for 12 months now, using it for the aztreonam study that I have been in. My PFT's hit the highest they have been in over 6 years last summer after only a few months of using the aztreonam/eflow. My PA count always goes down the month that I am using the drug while also, my coughing and sputum production goes down as well.
END OF QUOTE


Hello

Hope I've been able to successfully make a quote!!??
Anyhow, I was wondering if you could share more about your experience on this thread?
I'm really interested in how you went in the study, and any others out there who have been involved in this study also.

Okay, I wasnt completely successful with the quote part...
 
D

dasjsmum

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>MCGrad2006</b></i>

Well I have had my eflow for 12 months now, using it for the aztreonam study that I have been in. My PFT's hit the highest they have been in over 6 years last summer after only a few months of using the aztreonam/eflow. My PA count always goes down the month that I am using the drug while also, my coughing and sputum production goes down as well.
END OF QUOTE


Hello

Hope I've been able to successfully make a quote!!??
Anyhow, I was wondering if you could share more about your experience on this thread?
I'm really interested in how you went in the study, and any others out there who have been involved in this study also.

Okay, I wasnt completely successful with the quote part...
 
M

MCGrad2006

Guest
I have been in the aztrenam study now for 13 months i believe. Its supposed to be a Tobi replacement sort of thing, so I do it just like Tobi, one month on the drug and one month off. When I started back in December of 2005, I was on either placebo or drug, I still dont know. Then after that since I had participated in the study, I was able to roll over into the 'open label' portion of the study. So, I was only on the experimental part for that month, and ever since then, I KNOW that I have been on the drug, hence the 'open label' name. Like I had mentioned, I use it with an eflow neb, which was provided to me, but I have to return when the open label is done, and also on my off months, so as not to distrurb the study or whatnot. They need to make sure that the neb will last.

I notice a huge difference in the months that I am on the drug vs. the months that I am not on the drug. My PFTs usually go up or at least stay steady, and apparently my PA numbers go down(I dont get the results of the culture as those are sent away to the company conducting the study). My cough also goes away. I was on IV's in Dec.- Jan. (got my PICC out just two weeks ago). During this time i was on three IV abx plus the aztreonam. Since I have been off of IV's (so just using the aztreonam), my PFT;s have gone up three points higher and my cough is pretty much completely gone.

I also got news at a recent study visit...only a month ago that the study results are being sent to the FDA very shortly, and that they expect to have the drug on the market this summer!! They are very positive that the drug will pass 'inspection' because everyone seems to be doing so well with it. The big difference between this drug and others out there now...and this is partly to do with the eflow...is that the drug gets down really far into the lungs where the ifection lies. Before now, its been so hard to get to those infections and thats why this drug is so effective!

I hope this helps, and dont worry about the quote thing...it took me a while to figure that out. PM me if you have any qyuestions! <3
 
M

MCGrad2006

Guest
I have been in the aztrenam study now for 13 months i believe. Its supposed to be a Tobi replacement sort of thing, so I do it just like Tobi, one month on the drug and one month off. When I started back in December of 2005, I was on either placebo or drug, I still dont know. Then after that since I had participated in the study, I was able to roll over into the 'open label' portion of the study. So, I was only on the experimental part for that month, and ever since then, I KNOW that I have been on the drug, hence the 'open label' name. Like I had mentioned, I use it with an eflow neb, which was provided to me, but I have to return when the open label is done, and also on my off months, so as not to distrurb the study or whatnot. They need to make sure that the neb will last.

I notice a huge difference in the months that I am on the drug vs. the months that I am not on the drug. My PFTs usually go up or at least stay steady, and apparently my PA numbers go down(I dont get the results of the culture as those are sent away to the company conducting the study). My cough also goes away. I was on IV's in Dec.- Jan. (got my PICC out just two weeks ago). During this time i was on three IV abx plus the aztreonam. Since I have been off of IV's (so just using the aztreonam), my PFT;s have gone up three points higher and my cough is pretty much completely gone.

I also got news at a recent study visit...only a month ago that the study results are being sent to the FDA very shortly, and that they expect to have the drug on the market this summer!! They are very positive that the drug will pass 'inspection' because everyone seems to be doing so well with it. The big difference between this drug and others out there now...and this is partly to do with the eflow...is that the drug gets down really far into the lungs where the ifection lies. Before now, its been so hard to get to those infections and thats why this drug is so effective!

I hope this helps, and dont worry about the quote thing...it took me a while to figure that out. PM me if you have any qyuestions! <3
 
M

MCGrad2006

Guest
I have been in the aztrenam study now for 13 months i believe. Its supposed to be a Tobi replacement sort of thing, so I do it just like Tobi, one month on the drug and one month off. When I started back in December of 2005, I was on either placebo or drug, I still dont know. Then after that since I had participated in the study, I was able to roll over into the 'open label' portion of the study. So, I was only on the experimental part for that month, and ever since then, I KNOW that I have been on the drug, hence the 'open label' name. Like I had mentioned, I use it with an eflow neb, which was provided to me, but I have to return when the open label is done, and also on my off months, so as not to distrurb the study or whatnot. They need to make sure that the neb will last.

I notice a huge difference in the months that I am on the drug vs. the months that I am not on the drug. My PFTs usually go up or at least stay steady, and apparently my PA numbers go down(I dont get the results of the culture as those are sent away to the company conducting the study). My cough also goes away. I was on IV's in Dec.- Jan. (got my PICC out just two weeks ago). During this time i was on three IV abx plus the aztreonam. Since I have been off of IV's (so just using the aztreonam), my PFT;s have gone up three points higher and my cough is pretty much completely gone.

I also got news at a recent study visit...only a month ago that the study results are being sent to the FDA very shortly, and that they expect to have the drug on the market this summer!! They are very positive that the drug will pass 'inspection' because everyone seems to be doing so well with it. The big difference between this drug and others out there now...and this is partly to do with the eflow...is that the drug gets down really far into the lungs where the ifection lies. Before now, its been so hard to get to those infections and thats why this drug is so effective!

I hope this helps, and dont worry about the quote thing...it took me a while to figure that out. PM me if you have any qyuestions! <3
 
D

dasjsmum

New member
Hey Thanks Caitlin

Do you know if thats how (it's called AIr isnt it? Is that the same one?) it will be administered once it hits the market? Would the usual dose be one month off one on I wonder? How long have you been on the aztrenam that you know for sure? Okay, I think you answered that sorry! Has it cut down the usual amount of IV's you would have had?

Thanks for taking the time to answer.

It's sounds fantastic, I think it's the drug that works on the PA. Only a few months and it might be on the market!! How exciting!!

Thanks so much for participating in the study, I know that it's a lot of work and extra time, but I think you would think it was worht it!


I just found this press release, thought it might be of interest ...
<a target=_blank class=ftalternatingbarlinklarge href="http://www.gilead.com/wt/sec/pr_943568">http://www.gilead.com/wt/sec/pr_943568</a>
 
D

dasjsmum

New member
Hey Thanks Caitlin

Do you know if thats how (it's called AIr isnt it? Is that the same one?) it will be administered once it hits the market? Would the usual dose be one month off one on I wonder? How long have you been on the aztrenam that you know for sure? Okay, I think you answered that sorry! Has it cut down the usual amount of IV's you would have had?

Thanks for taking the time to answer.

It's sounds fantastic, I think it's the drug that works on the PA. Only a few months and it might be on the market!! How exciting!!

Thanks so much for participating in the study, I know that it's a lot of work and extra time, but I think you would think it was worht it!


I just found this press release, thought it might be of interest ...
<a target=_blank class=ftalternatingbarlinklarge href="http://www.gilead.com/wt/sec/pr_943568">http://www.gilead.com/wt/sec/pr_943568</a>
 
D

dasjsmum

New member
Hey Thanks Caitlin

Do you know if thats how (it's called AIr isnt it? Is that the same one?) it will be administered once it hits the market? Would the usual dose be one month off one on I wonder? How long have you been on the aztrenam that you know for sure? Okay, I think you answered that sorry! Has it cut down the usual amount of IV's you would have had?

Thanks for taking the time to answer.

It's sounds fantastic, I think it's the drug that works on the PA. Only a few months and it might be on the market!! How exciting!!

Thanks so much for participating in the study, I know that it's a lot of work and extra time, but I think you would think it was worht it!


I just found this press release, thought it might be of interest ...
<a target=_blank class=ftalternatingbarlinklarge href="http://www.gilead.com/wt/sec/pr_943568">http://www.gilead.com/wt/sec/pr_943568</a>
 
N

NoExcuses

New member
the eFlow will be the delivery method for aztreonam.

there is fear about having yet another antibiotic that is outpatient. antibiotics develop resistance more quickly when they're outpatient (through nebs or pills) because patients skip doses, etc.

aztreonam kills PA, but isn't as effective as an aminoglycoside such as tobramycin. when an antibiotic is relative weaker against a bacteria, resistance tends to occure more quickly.

but i tend to be more in the denmark camp about treating PA at all costs because patients die of lung damange long beore they die of resistance to antibiotis.

but it's important to understand both pros and cons of every new med <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
N

NoExcuses

New member
the eFlow will be the delivery method for aztreonam.

there is fear about having yet another antibiotic that is outpatient. antibiotics develop resistance more quickly when they're outpatient (through nebs or pills) because patients skip doses, etc.

aztreonam kills PA, but isn't as effective as an aminoglycoside such as tobramycin. when an antibiotic is relative weaker against a bacteria, resistance tends to occure more quickly.

but i tend to be more in the denmark camp about treating PA at all costs because patients die of lung damange long beore they die of resistance to antibiotis.

but it's important to understand both pros and cons of every new med <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
N

NoExcuses

New member
the eFlow will be the delivery method for aztreonam.

there is fear about having yet another antibiotic that is outpatient. antibiotics develop resistance more quickly when they're outpatient (through nebs or pills) because patients skip doses, etc.

aztreonam kills PA, but isn't as effective as an aminoglycoside such as tobramycin. when an antibiotic is relative weaker against a bacteria, resistance tends to occure more quickly.

but i tend to be more in the denmark camp about treating PA at all costs because patients die of lung damange long beore they die of resistance to antibiotis.

but it's important to understand both pros and cons of every new med <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
J

jfarel

New member
Yeah, I'm glad there will be a new choice of drugs. I can't tolerate the tobi as my chest seizes up. I haven't tried the tobi w/ the eflow though, I wonder if that would make a difference, maybe?
 
J

jfarel

New member
Yeah, I'm glad there will be a new choice of drugs. I can't tolerate the tobi as my chest seizes up. I haven't tried the tobi w/ the eflow though, I wonder if that would make a difference, maybe?
 
J

jfarel

New member
Yeah, I'm glad there will be a new choice of drugs. I can't tolerate the tobi as my chest seizes up. I haven't tried the tobi w/ the eflow though, I wonder if that would make a difference, maybe?
 
C

chantelfox

New member
UGGhhhh..the EFlow. That thing causes me so much stress. I hate it. I always have to worry about how to keep it sterile. I used sterile water to clean it, but it's a pain in the but and I have to wonder if it's really sterile if I wash my hands with tap water then handle the EFlow to clean it. (I say used because I decided to go back to my Pari).

Do you have to use the E FLow for this drug, I wonder? How do you keep ithe EFLow sterile? (Tap water can have all sorts of bacteria goodies in it- so I don't think it's good to wash any nebulizer with unsterile tap water).
 
C

chantelfox

New member
UGGhhhh..the EFlow. That thing causes me so much stress. I hate it. I always have to worry about how to keep it sterile. I used sterile water to clean it, but it's a pain in the but and I have to wonder if it's really sterile if I wash my hands with tap water then handle the EFlow to clean it. (I say used because I decided to go back to my Pari).

Do you have to use the E FLow for this drug, I wonder? How do you keep ithe EFLow sterile? (Tap water can have all sorts of bacteria goodies in it- so I don't think it's good to wash any nebulizer with unsterile tap water).
 
C

chantelfox

New member
UGGhhhh..the EFlow. That thing causes me so much stress. I hate it. I always have to worry about how to keep it sterile. I used sterile water to clean it, but it's a pain in the but and I have to wonder if it's really sterile if I wash my hands with tap water then handle the EFlow to clean it. (I say used because I decided to go back to my Pari).

Do you have to use the E FLow for this drug, I wonder? How do you keep ithe EFLow sterile? (Tap water can have all sorts of bacteria goodies in it- so I don't think it's good to wash any nebulizer with unsterile tap water).
 
N

NoExcuses

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>chantelfox</b></i>



Do you have to use the E FLow for this drug, I wonder?.</end quote></div>

Aztreonam is being brought to the market with the eFlow. So yes, you can't do it with any other neb.

I'm curious how you have a hard time keeping it sterile but you don't have a hard time keeping your old nebs sterile? what do you do differently between the two nebs?
 
N

NoExcuses

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>chantelfox</b></i>



Do you have to use the E FLow for this drug, I wonder?.</end quote></div>

Aztreonam is being brought to the market with the eFlow. So yes, you can't do it with any other neb.

I'm curious how you have a hard time keeping it sterile but you don't have a hard time keeping your old nebs sterile? what do you do differently between the two nebs?
 
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