My kid takes two in the morning and 1 in the evening, though I'm sure there are some that have started out on a lower dosage as per their doctors due to health issues
IMHO - I believe the recommendation that is followed is two of the one pill in the AM and 1 of the other pill at night. Then you see what side effects you get and decide (of course with the doctors objections) you figure out what works best for your situation. you can also google search it... https://www.drugs.com/dosage/trikafta.html
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