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- Thread starter NoExcuses
- Start date
eFlow Update
Amy,
The eflow seems to be a good nebulizer/compressor, however it has not been used for very long and the studies are somewhat limited (I will explain). I have the same material you have seen and I am impressed with the eflow and excited about trying it--hopefully very soon.
What I would like to see is a comparison (fev1 scores) between those using the eflow with tobi and pulmozyme and those using other standard neb compressors approved for use with tobi and pulmozyme. This study would probably have to be conducted on cf patients who are just starting therapy with Tobi and Pulmozyme. I'd also like to see a comparison of fev1 scores 6 months after switching from the standard neb and compressor to the pari eflow--this could be done with those cf patients already nebbing tobi and pulmozyme.
According to studies less medicine is needed because the droplet size of the aerosol is reduced and more gets into the airways. That sounds like a great thing and it seems that result in greater improvement in lung function. To date I have not seen statistics on lung function when patients switch to the eflow. Certainly if they remain stable or improve their fev1 scores it is worth using.
John
Amy,
The eflow seems to be a good nebulizer/compressor, however it has not been used for very long and the studies are somewhat limited (I will explain). I have the same material you have seen and I am impressed with the eflow and excited about trying it--hopefully very soon.
What I would like to see is a comparison (fev1 scores) between those using the eflow with tobi and pulmozyme and those using other standard neb compressors approved for use with tobi and pulmozyme. This study would probably have to be conducted on cf patients who are just starting therapy with Tobi and Pulmozyme. I'd also like to see a comparison of fev1 scores 6 months after switching from the standard neb and compressor to the pari eflow--this could be done with those cf patients already nebbing tobi and pulmozyme.
According to studies less medicine is needed because the droplet size of the aerosol is reduced and more gets into the airways. That sounds like a great thing and it seems that result in greater improvement in lung function. To date I have not seen statistics on lung function when patients switch to the eflow. Certainly if they remain stable or improve their fev1 scores it is worth using.
John
eFlow Update
Amy,
The eflow seems to be a good nebulizer/compressor, however it has not been used for very long and the studies are somewhat limited (I will explain). I have the same material you have seen and I am impressed with the eflow and excited about trying it--hopefully very soon.
What I would like to see is a comparison (fev1 scores) between those using the eflow with tobi and pulmozyme and those using other standard neb compressors approved for use with tobi and pulmozyme. This study would probably have to be conducted on cf patients who are just starting therapy with Tobi and Pulmozyme. I'd also like to see a comparison of fev1 scores 6 months after switching from the standard neb and compressor to the pari eflow--this could be done with those cf patients already nebbing tobi and pulmozyme.
According to studies less medicine is needed because the droplet size of the aerosol is reduced and more gets into the airways. That sounds like a great thing and it seems that result in greater improvement in lung function. To date I have not seen statistics on lung function when patients switch to the eflow. Certainly if they remain stable or improve their fev1 scores it is worth using.
John
Amy,
The eflow seems to be a good nebulizer/compressor, however it has not been used for very long and the studies are somewhat limited (I will explain). I have the same material you have seen and I am impressed with the eflow and excited about trying it--hopefully very soon.
What I would like to see is a comparison (fev1 scores) between those using the eflow with tobi and pulmozyme and those using other standard neb compressors approved for use with tobi and pulmozyme. This study would probably have to be conducted on cf patients who are just starting therapy with Tobi and Pulmozyme. I'd also like to see a comparison of fev1 scores 6 months after switching from the standard neb and compressor to the pari eflow--this could be done with those cf patients already nebbing tobi and pulmozyme.
According to studies less medicine is needed because the droplet size of the aerosol is reduced and more gets into the airways. That sounds like a great thing and it seems that result in greater improvement in lung function. To date I have not seen statistics on lung function when patients switch to the eflow. Certainly if they remain stable or improve their fev1 scores it is worth using.
John
eFlow Update
Amy,
The eflow seems to be a good nebulizer/compressor, however it has not been used for very long and the studies are somewhat limited (I will explain). I have the same material you have seen and I am impressed with the eflow and excited about trying it--hopefully very soon.
What I would like to see is a comparison (fev1 scores) between those using the eflow with tobi and pulmozyme and those using other standard neb compressors approved for use with tobi and pulmozyme. This study would probably have to be conducted on cf patients who are just starting therapy with Tobi and Pulmozyme. I'd also like to see a comparison of fev1 scores 6 months after switching from the standard neb and compressor to the pari eflow--this could be done with those cf patients already nebbing tobi and pulmozyme.
According to studies less medicine is needed because the droplet size of the aerosol is reduced and more gets into the airways. That sounds like a great thing and it seems that result in greater improvement in lung function. To date I have not seen statistics on lung function when patients switch to the eflow. Certainly if they remain stable or improve their fev1 scores it is worth using.
John
Amy,
The eflow seems to be a good nebulizer/compressor, however it has not been used for very long and the studies are somewhat limited (I will explain). I have the same material you have seen and I am impressed with the eflow and excited about trying it--hopefully very soon.
What I would like to see is a comparison (fev1 scores) between those using the eflow with tobi and pulmozyme and those using other standard neb compressors approved for use with tobi and pulmozyme. This study would probably have to be conducted on cf patients who are just starting therapy with Tobi and Pulmozyme. I'd also like to see a comparison of fev1 scores 6 months after switching from the standard neb and compressor to the pari eflow--this could be done with those cf patients already nebbing tobi and pulmozyme.
According to studies less medicine is needed because the droplet size of the aerosol is reduced and more gets into the airways. That sounds like a great thing and it seems that result in greater improvement in lung function. To date I have not seen statistics on lung function when patients switch to the eflow. Certainly if they remain stable or improve their fev1 scores it is worth using.
John
eFlow Update
John, what do you use for your current compressor for TOBI and pulmozyme? Many people use compressors that aren't even listed on the prescribing information (and don't know it), but go by the InVitro data and respirable dose data to decide whether or not to use the compressor.
I would be interested to hear what combination of compressor/nebulizer you use.
The studies that you suggest will never happen for medications that have already been brought to market. CFers are too small of a market and clinical studies that you suggest are too costly. It ain't gunna happen.
Taking a look at serum levels after a dose of TOBI or enzyme concentration in sputum after a dose of Pulmozyme is going to have to suffice.
John, what do you use for your current compressor for TOBI and pulmozyme? Many people use compressors that aren't even listed on the prescribing information (and don't know it), but go by the InVitro data and respirable dose data to decide whether or not to use the compressor.
I would be interested to hear what combination of compressor/nebulizer you use.
The studies that you suggest will never happen for medications that have already been brought to market. CFers are too small of a market and clinical studies that you suggest are too costly. It ain't gunna happen.
Taking a look at serum levels after a dose of TOBI or enzyme concentration in sputum after a dose of Pulmozyme is going to have to suffice.
eFlow Update
John, what do you use for your current compressor for TOBI and pulmozyme? Many people use compressors that aren't even listed on the prescribing information (and don't know it), but go by the InVitro data and respirable dose data to decide whether or not to use the compressor.
I would be interested to hear what combination of compressor/nebulizer you use.
The studies that you suggest will never happen for medications that have already been brought to market. CFers are too small of a market and clinical studies that you suggest are too costly. It ain't gunna happen.
Taking a look at serum levels after a dose of TOBI or enzyme concentration in sputum after a dose of Pulmozyme is going to have to suffice.
John, what do you use for your current compressor for TOBI and pulmozyme? Many people use compressors that aren't even listed on the prescribing information (and don't know it), but go by the InVitro data and respirable dose data to decide whether or not to use the compressor.
I would be interested to hear what combination of compressor/nebulizer you use.
The studies that you suggest will never happen for medications that have already been brought to market. CFers are too small of a market and clinical studies that you suggest are too costly. It ain't gunna happen.
Taking a look at serum levels after a dose of TOBI or enzyme concentration in sputum after a dose of Pulmozyme is going to have to suffice.
eFlow Update
John, what do you use for your current compressor for TOBI and pulmozyme? Many people use compressors that aren't even listed on the prescribing information (and don't know it), but go by the InVitro data and respirable dose data to decide whether or not to use the compressor.
I would be interested to hear what combination of compressor/nebulizer you use.
The studies that you suggest will never happen for medications that have already been brought to market. CFers are too small of a market and clinical studies that you suggest are too costly. It ain't gunna happen.
Taking a look at serum levels after a dose of TOBI or enzyme concentration in sputum after a dose of Pulmozyme is going to have to suffice.
John, what do you use for your current compressor for TOBI and pulmozyme? Many people use compressors that aren't even listed on the prescribing information (and don't know it), but go by the InVitro data and respirable dose data to decide whether or not to use the compressor.
I would be interested to hear what combination of compressor/nebulizer you use.
The studies that you suggest will never happen for medications that have already been brought to market. CFers are too small of a market and clinical studies that you suggest are too costly. It ain't gunna happen.
Taking a look at serum levels after a dose of TOBI or enzyme concentration in sputum after a dose of Pulmozyme is going to have to suffice.
eFlow Update
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.
eFlow Update
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.
eFlow Update
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.
eFlow Update
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>anonymous</b></i>
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.</end quote></div>
You said that you've read the studies above.
if you had, you would see that the studies include sputum concentrations and serum levels <img src="i/expressions/face-icon-small-tongue.gif" border="0">
you might be suprised to know that the PARI ProNeb of any kind have not been tested for use with Pulmozyme or TOBI. Look at the prescribing information for both of the drugs.
but why is the PARI ProNeb used so widely? Because of in vitro and in vivo studies that have been conducted regarding respirable doses and serum/sputum concentrations.
same thing is happening with the eFLow.
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>anonymous</b></i>
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.</end quote></div>
You said that you've read the studies above.
if you had, you would see that the studies include sputum concentrations and serum levels <img src="i/expressions/face-icon-small-tongue.gif" border="0">
you might be suprised to know that the PARI ProNeb of any kind have not been tested for use with Pulmozyme or TOBI. Look at the prescribing information for both of the drugs.
but why is the PARI ProNeb used so widely? Because of in vitro and in vivo studies that have been conducted regarding respirable doses and serum/sputum concentrations.
same thing is happening with the eFLow.
eFlow Update
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>anonymous</b></i>
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.</end quote></div>
You said that you've read the studies above.
if you had, you would see that the studies include sputum concentrations and serum levels <img src="i/expressions/face-icon-small-tongue.gif" border="0">
you might be suprised to know that the PARI ProNeb of any kind have not been tested for use with Pulmozyme or TOBI. Look at the prescribing information for both of the drugs.
but why is the PARI ProNeb used so widely? Because of in vitro and in vivo studies that have been conducted regarding respirable doses and serum/sputum concentrations.
same thing is happening with the eFLow.
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>anonymous</b></i>
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.</end quote></div>
You said that you've read the studies above.
if you had, you would see that the studies include sputum concentrations and serum levels <img src="i/expressions/face-icon-small-tongue.gif" border="0">
you might be suprised to know that the PARI ProNeb of any kind have not been tested for use with Pulmozyme or TOBI. Look at the prescribing information for both of the drugs.
but why is the PARI ProNeb used so widely? Because of in vitro and in vivo studies that have been conducted regarding respirable doses and serum/sputum concentrations.
same thing is happening with the eFLow.
eFlow Update
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>anonymous</b></i>
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.</end quote></div>
You said that you've read the studies above.
if you had, you would see that the studies include sputum concentrations and serum levels <img src="i/expressions/face-icon-small-tongue.gif" border="0">
you might be suprised to know that the PARI ProNeb of any kind have not been tested for use with Pulmozyme or TOBI. Look at the prescribing information for both of the drugs.
but why is the PARI ProNeb used so widely? Because of in vitro and in vivo studies that have been conducted regarding respirable doses and serum/sputum concentrations.
same thing is happening with the eFLow.
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>anonymous</b></i>
Serum, sputum concentrations of the meds will probably suffice, you're right. I can't recall...have the already tested this area?
I did use the pari proneb turbo and will be switching today or tomorrow to the pari proneb ultra II. My old compressor is shot. Nebulizers I use are the pari lc plus.</end quote></div>
You said that you've read the studies above.
if you had, you would see that the studies include sputum concentrations and serum levels <img src="i/expressions/face-icon-small-tongue.gif" border="0">
you might be suprised to know that the PARI ProNeb of any kind have not been tested for use with Pulmozyme or TOBI. Look at the prescribing information for both of the drugs.
but why is the PARI ProNeb used so widely? Because of in vitro and in vivo studies that have been conducted regarding respirable doses and serum/sputum concentrations.
same thing is happening with the eFLow.