i am just wondering what exactly cf gene testing involves as i am due to get tested some time soon. my sisterhas recently been tested and she is negetive for carrying the gene but it runs in out family what are the chances of me having it and what are the chances of my children having the gene thanks 18 yr old female w/cf xxxx
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cf gene testing im scarred
- Thread starter anonymous
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NoDayButToday
New member
If you have CF, you will definitely have two CF genes. I'm guessing your sister got tested to see if she was a carrier- which is when someone has one 'normal' gene and one mutated 'CF' gene. So if you have CF, the chances of you having it are unfortunately 100%. 1 in 20 people in America carry the CF gene. As for your children having it, it depends on whether you marry a carrier or not. There is a 100% chance that they will be a carrier, because you will inevitably contribute a CF gene. If your partner is a carrier, there is a 50% chance they will only be a carrier, and a 50% chance they will have CF. I think the test just involves a blood draw, or maybe a swab of the mouth.
purpleangel28282
New member
I just wanted to correct something Coll said about the chances that any of your children would have CF if you and your partner were to both be carriers of the CF gene, there is a 50% chance that they will become carriers of the gene, a 25% chance that they will have CF, and a 25% chance that they will not have CF nor be a carrier.
To the origional poster, the CF gene testing is a blood test. They drew two vials of blood from my forearm when they tested me.
As far as the chance of you having it, that would depend fully on who in your family has CF or is a CF gene carrier, and even knowing that information, you would have a percentage of being a carrier, a percentage of not being a carrier at all, and possibly a percentage of having CF. But as I said, that really depends on who in your family has CF history.
And I second the clarification Naomi gave you about the percentages. If you find out you are a carrier, I would HIGHLY recommend that when you get married and decide to have kids, your husband get tested to see if he is a carrier as well. If only one of you are a carrier, your children will not have cf, and I am pretty sure the chance of them being a carrier are also none, because both of you have to be carriers.
Best of luck,
Julie
As far as the chance of you having it, that would depend fully on who in your family has CF or is a CF gene carrier, and even knowing that information, you would have a percentage of being a carrier, a percentage of not being a carrier at all, and possibly a percentage of having CF. But as I said, that really depends on who in your family has CF history.
And I second the clarification Naomi gave you about the percentages. If you find out you are a carrier, I would HIGHLY recommend that when you get married and decide to have kids, your husband get tested to see if he is a carrier as well. If only one of you are a carrier, your children will not have cf, and I am pretty sure the chance of them being a carrier are also none, because both of you have to be carriers.
Best of luck,
Julie
<blockquote>Quote<br><hr>If only one of you are a carrier, your children will not have cf, and I am pretty sure the chance of them being a carrier are also none, because both of you have to be carriers<hr></blockquote>
If you are a carrier, you can pass the CF gene on to your child (even if your partner is NOT a carrier). You have 2 genes for everything (1 from mom and 1 from dad). A carrier has 1 "normal" gene and 1 CF gene. The carrier will, in turn, pass one of those genes on to their child. You don't know which gene you are going to pass on.
If you are a carrier, you can pass the CF gene on to your child (even if your partner is NOT a carrier). You have 2 genes for everything (1 from mom and 1 from dad). A carrier has 1 "normal" gene and 1 CF gene. The carrier will, in turn, pass one of those genes on to their child. You don't know which gene you are going to pass on.
Ok, here's the exact breakdown because I was wrong the first time I posted and appreciate the corrections as I really should have done my research first...sorry!
Carrier parent/Carrier parent Carrier Parent/CF Parent Non-carrier Parent/CF Parent Non-carrier Parent/Carrier Parent
25% unaffected 50% affected 100% unaffected carrier 50% unaffected
50% unaffected carrier 50% unaffected carrier 50% unaffected carrier
25% chance Affected (CF)
I hope this helps, and sorry I posted incorrectly earlier,
Julie
Carrier parent/Carrier parent Carrier Parent/CF Parent Non-carrier Parent/CF Parent Non-carrier Parent/Carrier Parent
25% unaffected 50% affected 100% unaffected carrier 50% unaffected
50% unaffected carrier 50% unaffected carrier 50% unaffected carrier
25% chance Affected (CF)
I hope this helps, and sorry I posted incorrectly earlier,
Julie
NoDayButToday
New member
<blockquote>Quote<br><hr>18 yr old female w/cf xxxx <hr></blockquote>
Actually, since the girl who posted appears to have CF, I'm pretty sure that my percentages are correct. Because she has CF, she will inevitably contribute a CF gene. So no matter what her child would be a carrier, and if her partner is a carrier, there is a 50% chance the child would have CF.
Actually, since the girl who posted appears to have CF, I'm pretty sure that my percentages are correct. Because she has CF, she will inevitably contribute a CF gene. So no matter what her child would be a carrier, and if her partner is a carrier, there is a 50% chance the child would have CF.
EmilysMini
New member
just for fun i thought i would put an easy to follow box they taught me in bio that shows how to figure it out.
...............F.............l........f
...........________ l_______ Key
..........l...................l..................l F=currupted gene
..........l...................l..................l f=normal gene
....F....l......FF........l......Ff........l
..........l...................l..................l
------------------------------------
..........l...................l..................l
...f......l......Ff..........l.....ff...........l
..........l...................l..................l
..........l________ l________l
(wow that was a b**ch) now for the easy to follow steps
(note: all the little dots are just so it wont get screwed up when i post it, so ignore them)
in the example above i chose 2 people that are carriers. there was a 25% chance of having CF, a 50% chance of being a carrier, and a 25% chance of having no affiliation with the gene at all.
now. as i hope we all know. each parent has 2 genes, but only contributes one of them. so pick a senario and plug it in. one gene next to each of those line coming out of the box. youll need to pick a letter to represent the gene, and it must be the same letter for both the currupted and uncurrupted gene, just capital and lower case. then its a simple matter of combining the letter inside the box. Just do as its shown. put the letters in the box that across or below it. hope that made sense. it makes for a fun party game so show your friends. (note: i was joking. it makes a horrible party game. but is an interesting thing to learn.) this works for many diffrent types of traits. just not the compound ones. that is for another time
...............F.............l........f
...........________ l_______ Key
..........l...................l..................l F=currupted gene
..........l...................l..................l f=normal gene
....F....l......FF........l......Ff........l
..........l...................l..................l
------------------------------------
..........l...................l..................l
...f......l......Ff..........l.....ff...........l
..........l...................l..................l
..........l________ l________l
(wow that was a b**ch) now for the easy to follow steps
(note: all the little dots are just so it wont get screwed up when i post it, so ignore them)
in the example above i chose 2 people that are carriers. there was a 25% chance of having CF, a 50% chance of being a carrier, and a 25% chance of having no affiliation with the gene at all.
now. as i hope we all know. each parent has 2 genes, but only contributes one of them. so pick a senario and plug it in. one gene next to each of those line coming out of the box. youll need to pick a letter to represent the gene, and it must be the same letter for both the currupted and uncurrupted gene, just capital and lower case. then its a simple matter of combining the letter inside the box. Just do as its shown. put the letters in the box that across or below it. hope that made sense. it makes for a fun party game so show your friends. (note: i was joking. it makes a horrible party game. but is an interesting thing to learn.) this works for many diffrent types of traits. just not the compound ones. that is for another time
Here is the breakdown again, I didn't really post well the first time so i'll try something different
Carrier parent/Carrier Parent
25% chance unaffected, 50% chance unaffected carrier, 25% chance CF
Carrier Parent/CF parent
50% chance CF, 50% chance unaffected carrier
Non-carrier parent/CF parent
100% chance unaffected carrier
Non-carrier parent/Carrier parent
50% unaffected (no carrier, no cf), 50% chance unaffected carrier
I hope this makes more sense than my previous post. This is from the book Growing older with CF, by Solvay Pharmaceuticals.
Julie
Carrier parent/Carrier Parent
25% chance unaffected, 50% chance unaffected carrier, 25% chance CF
Carrier Parent/CF parent
50% chance CF, 50% chance unaffected carrier
Non-carrier parent/CF parent
100% chance unaffected carrier
Non-carrier parent/Carrier parent
50% unaffected (no carrier, no cf), 50% chance unaffected carrier
I hope this makes more sense than my previous post. This is from the book Growing older with CF, by Solvay Pharmaceuticals.
Julie