Hi, I usually only get around to cleaning it when the chamber gets too much powder in it. You know the powder from the steroid inhaler, like advair or flovent. It should probably be cleaned more often but I tend to forget about it. To clean it, I just use hot soapy water and a wash cloth, shake all the excess water off and use a paper towel to dry it then let it air dry the rest of the way before putting it back together.