Hi Eric, I am taking 500 mg. of glutathione ( orally) 3 times a day, sometimes 4 times a day. I take each dose with 500 mg vit.C to help with the uptake of the gsh (glutathione). I have been using oral gsh since May of 2003. I saw results quickly in the way of having way more energy. I may decide to up the does of what i am taking now to see if it makes any difference . Good luck <img src="i/expressions/face-icon-small-smile.gif" border="0">~Diane 39 / cf / diabetes / b.cepacia