I use the Vest and do it twice daily after my albeuterol & pulmicort. I try to do it before I take my daughter to school in the morning, but if I cant manage to get up at 6am then I do it after dropping her off which is at 8:15 or so. My evening treatment is done between 7 & 7:30 at night. My vest I do for a good 45 minutes or so. I dont use it just for my lungs, but it helps my back relax since I have a lot of muscular issues with it.