Oral zyvox is just as effective as IV's but keep in mind when you get IV's Vaco wouldn't be the only one you're on. Usually you get a cocktail.
I've taken Zyvox a few times when I really thought my MRSA was outta control but my Pseudo wasn't. If I think both are out of control, then I'll try a sweet oral combo - think Zyvox and levequin, and if that doesn't perk me up, or if I fall ill quickly after the course is done my fate is sealed; IV's it is.
Zyvox, for me, works really well. It's one of my favorite orals for my MRSA strands.