I was wondering if you build up tolerance to Megace ES over time? I was on Marinol on and off for a while, but after a week or so on i would stop getting the benefits. Then I'd take week off, then go back on, etc. The problem with this program is that I was getting too sick too often to really be able to afford one week without being hungry. I recently switched to Megace ES, and I like it a lot better so far. The hunger is more even over the day (rather than 30 mins after the dose) and it doesn't make me sit down and only be able to think about food. I was just wondering if the tolerance thing can occur with this drug too? I realize Marinol is THC and Megace is a hormorne so I was wondering if that would make it so I could just take this indefinitly without any tolerance building up.