I am PI (severely failure to thrive as a child) and while in college, really noticed that fat was the main culprit for my stomach aches (which were daily with enzymes). I cut out fat, and before I realized it, my stomach aches were quite rare. Without the pain to remind me (and busy as heck in college) I forgot to take my enzymes more and more often. By my sophmore year, I didnt take them at all. Much to everyone's surprise my bad gas, bloating, nasty-smelling poo's, and all the other stuff had gone away......and have pretty much stayed away for almost 25 years. (the only exceptions being when I take oral antibiotics some of the "CF poo" comes back for a brief period of time, but goes away quickly) Within a short period of time of stopping the enzymes, I started having trouble keeping weight OFF and that is still an issue for me. My doc thinks I colonized specific bacteria to do my GI work for me, in fact, he retested me for PI since he couldnt believe what was going on. So not everyone is the same.