I am a nurse who has a husband with CF. Medically, anything below 92% for more than 2-4 minutes is time for 02. Reason being, the sp02 level is "the amount of oxygen saturation reaching the brain". If you are recieving less oxygen than 92%, your brain is being deprived of much needed oxygen, in extreme cases causing Brain Damage. Now, there is a downside because too much 02 for too long can cause problems as well such as dependency, withdrawl (when taken off) that can be sever, drying out of the nose (discomfort). I say, start SMALL and only keep it till the 02 comes back up to 94-95. Take it off and see if the body can maintain that level on it's own.