question

amber682

New member
I was just reading the CF NEWS FROM AROUND THE WORLD newsletter that gets e-mailed to me and this confused me. I posted the whole thing so you could read it if you want, but you really don't even need to, just look at the highlighted part. It doesn't seem right to me...

Worldwide Biotech

January 1, 2007

US FAST-TRACKS PHARMAXIS CYSTIC FIBROSIS DRUG.


Pharmaceutical company Pharmaxis (NASDAQ<img src="i/expressions/face-icon-small-tongue.gif" border="0">XSL), Sidney, Australia,has announced
that the US Food and Drug Administration has designated Bronchitol as a
fast-track product for cystic fibrosis.

The FDA fast-tracks the New Drug Application (NDA) process if a therapy can
potentially address an unmet medical need for a life-threatening disease.
Designation as a fast-track product is designed to expedite regulatory review of
the Bronchitol NDA. The FDA and European Medicines Agency have both previously
granted Bronchitol orphan drug status for treating cystic fibrosis.

Pharmaxis chief executive officer Dr Alan Robertson said: "The FDAdecision is
encouraging news for thousands of cystic fibrosis patients. It recognises the
positive clinical data for Bronchitol in treating cystic fibrosis, which is a
lethal inherited condition.

"This designation will speed the process of bringing this potentially
life-saving drug to cystic fibrosis sufferers.

"Phase II studies show Bronchitol significantly improves lung function and
wellbeing in patients with cystic fibrosis. We look forward to working with the
FDA on introducing Bronchitol to the U.S. market as rapidly as possible."

Pharmaxis is currently conducting Phase III and II clinical trialsof Bronchitol
in cystic fibrosis patients at sites in Europe, Canada, Argentina and Australia.

<span class="FTHighlightFont">Cystic fibrosis affects approximately 75,000 people in the developed world,
including 33,000 US patients and 2,500 Australians -- a fifth of whom are
children under five years old. There have been no treatment advances in over a
decade, and no products are approved to improve lung hydration.</span ft>

Designation as a fast track product enables Pharmaxis to file the new drug
application on a rolling basis as data becomes available, allowing the FDA to
review the application in sections ahead of receiving the complete submission. A
complete submission is expected to be made in 2008.

Pharmaxis is developing Bronchitol as a treatment to improve mucusclearance in the lungs of patients
with cystic fibrosis, bronchiectasis and chronic obstructive pulmonary diseases.
Bronchitol is a patented, inhalable dry powder formulation of mannitol
administered by a hand-held, pocket sized device.




That last highlighted sentence?
 

amber682

New member
I was just reading the CF NEWS FROM AROUND THE WORLD newsletter that gets e-mailed to me and this confused me. I posted the whole thing so you could read it if you want, but you really don't even need to, just look at the highlighted part. It doesn't seem right to me...

Worldwide Biotech

January 1, 2007

US FAST-TRACKS PHARMAXIS CYSTIC FIBROSIS DRUG.


Pharmaceutical company Pharmaxis (NASDAQ<img src="i/expressions/face-icon-small-tongue.gif" border="0">XSL), Sidney, Australia,has announced
that the US Food and Drug Administration has designated Bronchitol as a
fast-track product for cystic fibrosis.

The FDA fast-tracks the New Drug Application (NDA) process if a therapy can
potentially address an unmet medical need for a life-threatening disease.
Designation as a fast-track product is designed to expedite regulatory review of
the Bronchitol NDA. The FDA and European Medicines Agency have both previously
granted Bronchitol orphan drug status for treating cystic fibrosis.

Pharmaxis chief executive officer Dr Alan Robertson said: "The FDAdecision is
encouraging news for thousands of cystic fibrosis patients. It recognises the
positive clinical data for Bronchitol in treating cystic fibrosis, which is a
lethal inherited condition.

"This designation will speed the process of bringing this potentially
life-saving drug to cystic fibrosis sufferers.

"Phase II studies show Bronchitol significantly improves lung function and
wellbeing in patients with cystic fibrosis. We look forward to working with the
FDA on introducing Bronchitol to the U.S. market as rapidly as possible."

Pharmaxis is currently conducting Phase III and II clinical trialsof Bronchitol
in cystic fibrosis patients at sites in Europe, Canada, Argentina and Australia.

<span class="FTHighlightFont">Cystic fibrosis affects approximately 75,000 people in the developed world,
including 33,000 US patients and 2,500 Australians -- a fifth of whom are
children under five years old. There have been no treatment advances in over a
decade, and no products are approved to improve lung hydration.</span ft>

Designation as a fast track product enables Pharmaxis to file the new drug
application on a rolling basis as data becomes available, allowing the FDA to
review the application in sections ahead of receiving the complete submission. A
complete submission is expected to be made in 2008.

Pharmaxis is developing Bronchitol as a treatment to improve mucusclearance in the lungs of patients
with cystic fibrosis, bronchiectasis and chronic obstructive pulmonary diseases.
Bronchitol is a patented, inhalable dry powder formulation of mannitol
administered by a hand-held, pocket sized device.




That last highlighted sentence?
 

amber682

New member
I was just reading the CF NEWS FROM AROUND THE WORLD newsletter that gets e-mailed to me and this confused me. I posted the whole thing so you could read it if you want, but you really don't even need to, just look at the highlighted part. It doesn't seem right to me...

Worldwide Biotech

January 1, 2007

US FAST-TRACKS PHARMAXIS CYSTIC FIBROSIS DRUG.


Pharmaceutical company Pharmaxis (NASDAQ<img src="i/expressions/face-icon-small-tongue.gif" border="0">XSL), Sidney, Australia,has announced
that the US Food and Drug Administration has designated Bronchitol as a
fast-track product for cystic fibrosis.

The FDA fast-tracks the New Drug Application (NDA) process if a therapy can
potentially address an unmet medical need for a life-threatening disease.
Designation as a fast-track product is designed to expedite regulatory review of
the Bronchitol NDA. The FDA and European Medicines Agency have both previously
granted Bronchitol orphan drug status for treating cystic fibrosis.

Pharmaxis chief executive officer Dr Alan Robertson said: "The FDAdecision is
encouraging news for thousands of cystic fibrosis patients. It recognises the
positive clinical data for Bronchitol in treating cystic fibrosis, which is a
lethal inherited condition.

"This designation will speed the process of bringing this potentially
life-saving drug to cystic fibrosis sufferers.

"Phase II studies show Bronchitol significantly improves lung function and
wellbeing in patients with cystic fibrosis. We look forward to working with the
FDA on introducing Bronchitol to the U.S. market as rapidly as possible."

Pharmaxis is currently conducting Phase III and II clinical trialsof Bronchitol
in cystic fibrosis patients at sites in Europe, Canada, Argentina and Australia.

<span class="FTHighlightFont">Cystic fibrosis affects approximately 75,000 people in the developed world,
including 33,000 US patients and 2,500 Australians -- a fifth of whom are
children under five years old. There have been no treatment advances in over a
decade, and no products are approved to improve lung hydration.</span ft>

Designation as a fast track product enables Pharmaxis to file the new drug
application on a rolling basis as data becomes available, allowing the FDA to
review the application in sections ahead of receiving the complete submission. A
complete submission is expected to be made in 2008.

Pharmaxis is developing Bronchitol as a treatment to improve mucusclearance in the lungs of patients
with cystic fibrosis, bronchiectasis and chronic obstructive pulmonary diseases.
Bronchitol is a patented, inhalable dry powder formulation of mannitol
administered by a hand-held, pocket sized device.




That last highlighted sentence?
 
2

2perfectboys

Guest
yes, i think they consider pulmozyme and tobi the last advances
 
2

2perfectboys

Guest
yes, i think they consider pulmozyme and tobi the last advances
 
2

2perfectboys

Guest
yes, i think they consider pulmozyme and tobi the last advances
 

Alyssa

New member
On another list I am on, I have seen several people hold this exact same opinion, so perhaps it is true.

I know Pulmozyme came out in the 80's, I don't know about Tobi and I believe the recent use of 7% saline is suppose to help hydrated the lungs but that has not been officially declared as a "new" or "approved" drug treatment, the CF docs are just prescribing it.

Also one person who is now 75 years old can remember several decades of CFF statistics and he says the "30,000 persons with CF" figure that the CFF quotes has never changed.
 

Alyssa

New member
On another list I am on, I have seen several people hold this exact same opinion, so perhaps it is true.

I know Pulmozyme came out in the 80's, I don't know about Tobi and I believe the recent use of 7% saline is suppose to help hydrated the lungs but that has not been officially declared as a "new" or "approved" drug treatment, the CF docs are just prescribing it.

Also one person who is now 75 years old can remember several decades of CFF statistics and he says the "30,000 persons with CF" figure that the CFF quotes has never changed.
 

Alyssa

New member
On another list I am on, I have seen several people hold this exact same opinion, so perhaps it is true.

I know Pulmozyme came out in the 80's, I don't know about Tobi and I believe the recent use of 7% saline is suppose to help hydrated the lungs but that has not been officially declared as a "new" or "approved" drug treatment, the CF docs are just prescribing it.

Also one person who is now 75 years old can remember several decades of CFF statistics and he says the "30,000 persons with CF" figure that the CFF quotes has never changed.
 

NoExcuses

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Alyssa</b></i>


Also one person who is now 75 years old can remember several decades of CFF statistics and he says the "30,000 persons with CF" figure that the CFF quotes has never changed.</end quote></div>

never changes cuz people keep DYING. and the gene pool is about the same so the same # of CFers are being born
 

NoExcuses

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Alyssa</b></i>


Also one person who is now 75 years old can remember several decades of CFF statistics and he says the "30,000 persons with CF" figure that the CFF quotes has never changed.</end quote></div>

never changes cuz people keep DYING. and the gene pool is about the same so the same # of CFers are being born
 

NoExcuses

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Alyssa</b></i>


Also one person who is now 75 years old can remember several decades of CFF statistics and he says the "30,000 persons with CF" figure that the CFF quotes has never changed.</end quote></div>

never changes cuz people keep DYING. and the gene pool is about the same so the same # of CFers are being born
 

Alyssa

New member
Could be.... but I think his complaint was also with the reporting of data back to the registry. He felt that too many people were not being counted because they were not being treated by a CFF center. If you see any other pulmo or GI doc you cannot report to the registry. And with so many mild cases being diagnosed later in life, (30 or 40 years old) the numbers have to be increasing.
 

Alyssa

New member
Could be.... but I think his complaint was also with the reporting of data back to the registry. He felt that too many people were not being counted because they were not being treated by a CFF center. If you see any other pulmo or GI doc you cannot report to the registry. And with so many mild cases being diagnosed later in life, (30 or 40 years old) the numbers have to be increasing.
 

Alyssa

New member
Could be.... but I think his complaint was also with the reporting of data back to the registry. He felt that too many people were not being counted because they were not being treated by a CFF center. If you see any other pulmo or GI doc you cannot report to the registry. And with so many mild cases being diagnosed later in life, (30 or 40 years old) the numbers have to be increasing.
 
2

2perfectboys

Guest
30,ooo is not an accurate # and I would say it has never been, but then they even say it is an estimate, and a very inaccurate one at that, i would say there are more than 30,000 americans w/ CF. The registery started 40 years ago and today only has 22,714 people they track, u can opt out of being a part of this or if u go to any center other than the 115 approved sites, u r not tracked. Simple math should tell u that if 1 in 3.500 births a CF person is more and more people are being born today than 10 years ago and less CF people are dying from the average age of 18 years ago to todays age of almost 37, that would account for a few more apples in the basket.
 
2

2perfectboys

Guest
30,ooo is not an accurate # and I would say it has never been, but then they even say it is an estimate, and a very inaccurate one at that, i would say there are more than 30,000 americans w/ CF. The registery started 40 years ago and today only has 22,714 people they track, u can opt out of being a part of this or if u go to any center other than the 115 approved sites, u r not tracked. Simple math should tell u that if 1 in 3.500 births a CF person is more and more people are being born today than 10 years ago and less CF people are dying from the average age of 18 years ago to todays age of almost 37, that would account for a few more apples in the basket.
 
2

2perfectboys

Guest
30,ooo is not an accurate # and I would say it has never been, but then they even say it is an estimate, and a very inaccurate one at that, i would say there are more than 30,000 americans w/ CF. The registery started 40 years ago and today only has 22,714 people they track, u can opt out of being a part of this or if u go to any center other than the 115 approved sites, u r not tracked. Simple math should tell u that if 1 in 3.500 births a CF person is more and more people are being born today than 10 years ago and less CF people are dying from the average age of 18 years ago to todays age of almost 37, that would account for a few more apples in the basket.
 
2

2perfectboys

Guest
also, about 1,000 new cases of CF are diagnoised each year while only 400 die every year, so there is about an extra 600 people with CF everyyear
 
2

2perfectboys

Guest
also, about 1,000 new cases of CF are diagnoised each year while only 400 die every year, so there is about an extra 600 people with CF everyyear
 
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