Those of us who are pancreatic insufficient actually lack bicarbonate, which helps naturally reduce acid in our stomach.
So many CFer's, despite not eating a few hours before bed, no caffine, mints, alcohol or spicy foods, yadi yadi yadi still have reflux. There's something no or not enough bicarbonate in our stomaches.
SO..... you can start taking your med twice a day (ask for doc's guidance but many of us, including myself, take our proton pump inhibitors [PPI] 2x a day); you can also make sure you're taking your PPI ask directed which is 30 - 60 minutes before a meal. This increases the medications efficacy.
Finally, you can supplement with Zantac (ranitidine) for breakthrough symptoms.
If things continue to not go well, this could mean there might be a physical issue with your esophagus and an endoscopy from a gastro would be necessary.
Take care