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semperfiohana
Guest
http://www.clinicaltrials.gov/ct2/show/NCT01531673
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S
semperfiohana
Guest
http://www.clinicaltrials.gov/ct2/show/NCT01531673
S
semperfiohana
Guest
i can't copy and paste in firefox and my internet explorer won't connect to the internet. i hope that link works that i typed in.
S
semperfiohana
Guest
i can't copy and paste in firefox and my internet explorer won't connect to the internet. i hope that link works that i typed in.
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semperfiohana
Guest
thank you!
S
semperfiohana
Guest
thank you!
saveferris2009
New member
only recruiting Double DF508. Interesting.....
hopefully those who live in the northeast will participate so we can get these results ASAP <img src="i/expressions/face-icon-small-smile.gif" border="0">
hopefully those who live in the northeast will participate so we can get these results ASAP <img src="i/expressions/face-icon-small-smile.gif" border="0">
saveferris2009
New member
only recruiting Double DF508. Interesting.....
hopefully those who live in the northeast will participate so we can get these results ASAP <img src="i/expressions/face-icon-small-smile.gif" border="0">
hopefully those who live in the northeast will participate so we can get these results ASAP <img src="i/expressions/face-icon-small-smile.gif" border="0">
C
cfsucks
Guest
is this a sign that vx809 and vx770 combo didnt work as planned, or that df508 doesnt need vx770 and may just need vx809 and vx661?
C
cfsucks
Guest
is this a sign that vx809 and vx770 combo didnt work as planned, or that df508 doesnt need vx770 and may just need vx809 and vx661?
saveferris2009
New member
809+770 didn't produce as great of results as expected, yes.
770 will absolutely be needed - but 661 might work better than 809. or there are thoughts that perhaps all 3 in conjunction, from what i heard.
as you see from the study link, they are combining 770 and 661..... not 809 and 661.
770 will absolutely be needed - but 661 might work better than 809. or there are thoughts that perhaps all 3 in conjunction, from what i heard.
as you see from the study link, they are combining 770 and 661..... not 809 and 661.
saveferris2009
New member
809+770 didn't produce as great of results as expected, yes.
770 will absolutely be needed - but 661 might work better than 809. or there are thoughts that perhaps all 3 in conjunction, from what i heard.
as you see from the study link, they are combining 770 and 661..... not 809 and 661.
770 will absolutely be needed - but 661 might work better than 809. or there are thoughts that perhaps all 3 in conjunction, from what i heard.
as you see from the study link, they are combining 770 and 661..... not 809 and 661.
C
cfsucks
Guest
oh sorry i misread the drugs involved. that's unfortunate- i was really hoping vx809 would show promising results!
C
cfsucks
Guest
oh sorry i misread the drugs involved. that's unfortunate- i was really hoping vx809 would show promising results!
saveferris2009
New member
This was from November of the Phase IIa clinical trial of 770+809. As you can see, the sweat chloride from baseline didn't decrease very dramatically after 21 days, on average. Mean decrease was - 9.10 mmol/L
It's not a complete fail - but it's definitely not what we saw with 770 and G551D. They had a mean decrease of -59.5 mmol/L.
It's thought that sweat chloride reduction will correlate well with increase in FEV1. So before doing a full on, huge, very costly study, they study a few patients with study endpoints of just sweat chloride.
http://investors.vrtx.com/releasedetail.cfm?ReleaseID=620638
It's not a complete fail - but it's definitely not what we saw with 770 and G551D. They had a mean decrease of -59.5 mmol/L.
It's thought that sweat chloride reduction will correlate well with increase in FEV1. So before doing a full on, huge, very costly study, they study a few patients with study endpoints of just sweat chloride.
http://investors.vrtx.com/releasedetail.cfm?ReleaseID=620638
saveferris2009
New member
This was from November of the Phase IIa clinical trial of 770+809. As you can see, the sweat chloride from baseline didn't decrease very dramatically after 21 days, on average. Mean decrease was - 9.10 mmol/L
It's not a complete fail - but it's definitely not what we saw with 770 and G551D. They had a mean decrease of -59.5 mmol/L.
It's thought that sweat chloride reduction will correlate well with increase in FEV1. So before doing a full on, huge, very costly study, they study a few patients with study endpoints of just sweat chloride.
http://investors.vrtx.com/releasedetail.cfm?ReleaseID=620638
It's not a complete fail - but it's definitely not what we saw with 770 and G551D. They had a mean decrease of -59.5 mmol/L.
It's thought that sweat chloride reduction will correlate well with increase in FEV1. So before doing a full on, huge, very costly study, they study a few patients with study endpoints of just sweat chloride.
http://investors.vrtx.com/releasedetail.cfm?ReleaseID=620638
musclemania70
New member
haven't there been people posting on here about 770/809 who are currently in the trial? I thought they said they were seeing big results.....but i know that is different that the actual NUMBERS they arewatching (sweat chloride/fev 1) I also wonder whyVertex would continue with the study if the results from Nov are not promising.....just to prove that it is not good enough? interesting...
musclemania70
New member
haven't there been people posting on here about 770/809 who are currently in the trial? I thought they said they were seeing big results.....but i know that is different that the actual NUMBERS they arewatching (sweat chloride/fev 1) I also wonder whyVertex would continue with the study if the results from Nov are not promising.....just to prove that it is not good enough? interesting...
S
semperfiohana
Guest
i came across this because i googled vx-661 and scrolled down through the results. it was like the 4th thing that popped up. hopefully they get the participation they need for the trial.
S
semperfiohana
Guest
i came across this because i googled vx-661 and scrolled down through the results. it was like the 4th thing that popped up. hopefully they get the participation they need for the trial.