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?where to find answer to this
- Thread starter anonymous
- Start date
If you have cf how do the mutations divide as far as having children? If you have two different mutations can you can you pass the same one to say every child you have? Is there some where to find the odds of that?
If you have two different mutations then you have CF and you will pass one of them to your child. And yes, you could possibly pass the same one to every child you have the odds are 50/50 as to which one you will pass.
If you are a carrier, meaning you only have one defective gene the odds are 50/50, either you will pass the good or you will pass the bad.
Jen
If you have two different mutations then you have CF and you will pass one of them to your child. And yes, you could possibly pass the same one to every child you have the odds are 50/50 as to which one you will pass.
If you are a carrier, meaning you only have one defective gene the odds are 50/50, either you will pass the good or you will pass the bad.
Jen
2
2sickkids
Guest
Jen thanx sometimes it does login automaticly and sometimes not. But that was me asking. As far as the two different mutation thing I ment not having two of the same. Like double deltaf508 which is what both of my boys have. I asked cause my doctors are adamant about doing a sweat test and blood work on me. While I was expecting my youngest the perinatoligist said there was no need to test because they knew my older sons mutations. My pulm wanted to test me when he found out my 1st had cf.
2
2sickkids
Guest
Which part of it?
They got one copy of the same mutation from their father and I.
Even thogh they both have the same type it does differnt things. Like both take high dose of enzymes and have some lung involvement. My oldest started losing weight as soon as he was born went real low and gained slow. Mostly digestive left lung if it he sick it is too hot cold or dry. Youngest started gaining fast was way up and. At 6wks started losing and at 8m old now is the same weight he was then. He has liver disease right lung problems always. 2 yr old takes in at least 3,700cal a day to stay the weight he is. The baby is losing at 800a day on a ng tube.
Wasn't sure if you ment how they got two of the same mutation or what it did to them. If that didn't answer the question let me know.
They got one copy of the same mutation from their father and I.
Even thogh they both have the same type it does differnt things. Like both take high dose of enzymes and have some lung involvement. My oldest started losing weight as soon as he was born went real low and gained slow. Mostly digestive left lung if it he sick it is too hot cold or dry. Youngest started gaining fast was way up and. At 6wks started losing and at 8m old now is the same weight he was then. He has liver disease right lung problems always. 2 yr old takes in at least 3,700cal a day to stay the weight he is. The baby is losing at 800a day on a ng tube.
Wasn't sure if you ment how they got two of the same mutation or what it did to them. If that didn't answer the question let me know.
If you have CF and you reproduce with someone who is not a carrier and who does not have CF, your children have a 100% of being carriers (unaffected).
Two carrier parents have a 25% chance of an unaffected child, 50% of an unaffected carrier and 25% chance affected.
One carrier parent and one CF parent have a 50% chance of being affected and 50% chance unaffected carrier.
One noncarrier parent and one carrier parent have a 50% chance of being unaffected, and a 50% chance of being an unaffected carrier.
A CF parent will pass 1 of their two mutations onto their child. If the CF parent has two of the same mutations; say double Delta F508-then they will pass one of the mutations. If they have two different mutations, say Delta F 508 and R117h (I don't think that's correct but for examples sake) they could pass either the DF508 or the R117h and there is no way to tell which one (siblings can carry different mutations) unless they get genotyped. Two parents who are both carriers and carry a different mutations can end up with a Child with CF (both of their different mutations) OR can end up with children as carriers and again, siblings in this situation can carry one of the two different mutations-so again you could only really know by ruling out CF and then haveing them genotyped.
I hope this helps,
Julie (wife to Mark 24 w/CF)
Two carrier parents have a 25% chance of an unaffected child, 50% of an unaffected carrier and 25% chance affected.
One carrier parent and one CF parent have a 50% chance of being affected and 50% chance unaffected carrier.
One noncarrier parent and one carrier parent have a 50% chance of being unaffected, and a 50% chance of being an unaffected carrier.
A CF parent will pass 1 of their two mutations onto their child. If the CF parent has two of the same mutations; say double Delta F508-then they will pass one of the mutations. If they have two different mutations, say Delta F 508 and R117h (I don't think that's correct but for examples sake) they could pass either the DF508 or the R117h and there is no way to tell which one (siblings can carry different mutations) unless they get genotyped. Two parents who are both carriers and carry a different mutations can end up with a Child with CF (both of their different mutations) OR can end up with children as carriers and again, siblings in this situation can carry one of the two different mutations-so again you could only really know by ruling out CF and then haveing them genotyped.
I hope this helps,
Julie (wife to Mark 24 w/CF)
Julie,
Your example in the last post was correct. Taylor could receive either the Delta F508 or the R117H. According to the genetic counselor she will inherit one of these traits. How then though do parents end up with children without CF and no carrier status? The genetic counselor's statement tells me Taylor has a 100% chance to carrier status is this correct?
To the original poster, this has got to be the most confusing data you will ever try to process, however the people on this sight are very knowledgable and helpfull.
Kathy
Your example in the last post was correct. Taylor could receive either the Delta F508 or the R117H. According to the genetic counselor she will inherit one of these traits. How then though do parents end up with children without CF and no carrier status? The genetic counselor's statement tells me Taylor has a 100% chance to carrier status is this correct?
To the original poster, this has got to be the most confusing data you will ever try to process, however the people on this sight are very knowledgable and helpfull.
Kathy
2
2sickkids
Guest
Yeah that is why I asked I figured if anyone could help me it would by somebody here. I think genetic's counselor's can be wrong sometimes. The one I saw told me and my husband they would test us for the gene to see if we both had it. We already had one child with CF and knew his mutations. But I was asking cause my doc is trying to tell me I have CF too. They said the test didn't test for enough to consider it reliable and that it was real likely I could have just passed the same one to both of my kids. But basicly it looks like the 50/50 odds are right.
Okay,
I had this all figured out until I started reading this thread.lol.
2sickkids-Do you have CF? I don't think I remember you having CF but I'm still a bit confused about your question with regard to how mutations are divided.
To my understanding they are randomly passed from generation to generation. And of course we all know the odds of two carriers having a child and so on.
Am I missing something here?
Jen
I had this all figured out until I started reading this thread.lol.
2sickkids-Do you have CF? I don't think I remember you having CF but I'm still a bit confused about your question with regard to how mutations are divided.
To my understanding they are randomly passed from generation to generation. And of course we all know the odds of two carriers having a child and so on.
Am I missing something here?
Jen
Dear 2sickkids,
I'm sorry, but after reading many of your posts, I can't stop myself from replying to this one. You have stated in other posts that your lung function is at 40%, you have asthma, chronic bronchitis, bronchiectasis, stomach problems and take insulin. With so many problems that are typical to CF, I think your doctors would be negligent to not request a CF sweat and/or blood test.
For the sake of your well-being and the well-being of your children's future, please consider your doctor's request.
Maria (mother of three daughters, the youngest Samantha w/cf)
I'm sorry, but after reading many of your posts, I can't stop myself from replying to this one. You have stated in other posts that your lung function is at 40%, you have asthma, chronic bronchitis, bronchiectasis, stomach problems and take insulin. With so many problems that are typical to CF, I think your doctors would be negligent to not request a CF sweat and/or blood test.
For the sake of your well-being and the well-being of your children's future, please consider your doctor's request.
Maria (mother of three daughters, the youngest Samantha w/cf)
2sickkids, have to agree with Maria's last post. All your sypmtoms seem very similar to those that have CF. I am not jumping to conclusions but I think it is essential that you have a genetic test. Currently ambry genetics (go to MSN search engine and type in ambry genetics) is the most advanced and I would recommend you request them. Also, since you have a child with CF there are two possibilities. Either both you and your husband are carriers which means your children will have a 25% chance of having CF, or one of you has CF (either you or your husband) and the other is a carrier. If that is the case, your children will have a 50% chance of having CF and a 50% chance of being JUST a CARRIER.
Kathy, as for your situation, it is very strange. But since your husband has two mutations (I hope I am remembering correctly) even though they are supposedly on the same chromosome (I am still waiting to talk to our genetic cousnelor about this) it would be logical that your children have 100% chance of being carriers-based on the breakdown of parent carrier status. That 100% carrier status stands true only if they determine that you are not a carrier.
To answer your second question, the only situation where parents would end up with a child without CF or even being a carrier is if #1, neither of them are carriers of ANY mutations and #2, One noncarrier parent and one carrier parent have a 50% chance of being unaffected (NOT A CARRIER AND NO CF), and a 50% chance of being an unaffected carrier (JUST A CARRIER).
Julie (wife to Mark 24 w/CF)
Kathy, as for your situation, it is very strange. But since your husband has two mutations (I hope I am remembering correctly) even though they are supposedly on the same chromosome (I am still waiting to talk to our genetic cousnelor about this) it would be logical that your children have 100% chance of being carriers-based on the breakdown of parent carrier status. That 100% carrier status stands true only if they determine that you are not a carrier.
To answer your second question, the only situation where parents would end up with a child without CF or even being a carrier is if #1, neither of them are carriers of ANY mutations and #2, One noncarrier parent and one carrier parent have a 50% chance of being unaffected (NOT A CARRIER AND NO CF), and a 50% chance of being an unaffected carrier (JUST A CARRIER).
Julie (wife to Mark 24 w/CF)
Julie,
Two mutations are not on one chromosome that was another poster. Husband has 2 different mutation with a neg, sweat test. They said he would pass 1 of the 2 mutations to his children. My question was if this is true, how then do CF patients have children with no mutations?
Kathy
Two mutations are not on one chromosome that was another poster. Husband has 2 different mutation with a neg, sweat test. They said he would pass 1 of the 2 mutations to his children. My question was if this is true, how then do CF patients have children with no mutations?
Kathy
Julie,
Two mutations are not on one chromosome that was another poster. Husband has 2 different mutation with a neg, sweat test. They said he would pass 1 of the 2 mutations to his children. My question was if this is true, how then do CF patients have children with no mutations?
Kathy
Two mutations are not on one chromosome that was another poster. Husband has 2 different mutation with a neg, sweat test. They said he would pass 1 of the 2 mutations to his children. My question was if this is true, how then do CF patients have children with no mutations?
Kathy
Kathy,
A cf parent cannot have a biological child that carries no cf mutations. THe child will absolutely have to carry one of the two mutations. If they test your dd, she will be a carrier of either DF508 or R117H. This parts only a guess, but with as low of a sweat test as she had, I would <b>guess</b> that she carries the R117H mutation. Has she had genetic testing? If so, make sure it's a panel that tests for R117H because I think the basic panel of 25 does not.
Sickkids, I agree wholeheartedly with everyone else. You need to have a sweat test and Ambry test done ASAP so you can be treated correctly, if not for your sake, for your children's sake. If you do have cf, each of your children had a 50% chance of getting the DF508 mutation from you. That's independent of each other. There's no way to determine the probability that you could have cf.
A cf parent cannot have a biological child that carries no cf mutations. THe child will absolutely have to carry one of the two mutations. If they test your dd, she will be a carrier of either DF508 or R117H. This parts only a guess, but with as low of a sweat test as she had, I would <b>guess</b> that she carries the R117H mutation. Has she had genetic testing? If so, make sure it's a panel that tests for R117H because I think the basic panel of 25 does not.
Sickkids, I agree wholeheartedly with everyone else. You need to have a sweat test and Ambry test done ASAP so you can be treated correctly, if not for your sake, for your children's sake. If you do have cf, each of your children had a 50% chance of getting the DF508 mutation from you. That's independent of each other. There's no way to determine the probability that you could have cf.
Kathy,
Hi- there is a strand in the Adults section titled "Gene Mutations???" - if you look at the post by Mary (Serendipity . . .), she gives a link to a genetics site that gives a lot of valuable info. There is also info specifically adressing the R117H mutation. From what I have been reading, when someone has R117H additional testing should be made to find out about presence or absence of 5T on intron 8. This can determine some aspects of phenotype (prognosis).
Its all very interesting but very complicated. Perhaps you can copy some of the info and share it with your doctor.
Maria
Hi- there is a strand in the Adults section titled "Gene Mutations???" - if you look at the post by Mary (Serendipity . . .), she gives a link to a genetics site that gives a lot of valuable info. There is also info specifically adressing the R117H mutation. From what I have been reading, when someone has R117H additional testing should be made to find out about presence or absence of 5T on intron 8. This can determine some aspects of phenotype (prognosis).
Its all very interesting but very complicated. Perhaps you can copy some of the info and share it with your doctor.
Maria
Sorry Kathy, I guess I was thinking of somebody else. It is genetically impossible for a CFer to have a BIOLOGICAL child who is not a carrier of 1 of their mutations. Since your husband has 2 different mutations, have they officially diagnosed him with CF? There's quite a few topics going on about situations like this right now so please forgive me if you have already discussed that.
Julie
Julie
Hi everyone I am new to this site. I am 26 yrs old and my f'eicne is 32. We have one child that is 7 with downs. She was born healthy and not severe at all, thank god! Well I am 13 weeks preg. and found out my partner and I carry the same gene I belive delta something? we r both carries of c.f So now I am goin in 3 weeks for a amio to see if the baby has it. I am so upset and think about this all the time. I got scared after giving birth to my daughter and now I am gettin all worked up and scared again. I know there is a 75%chance the baby wont but still I am very scared...Anyone out there to help me calm down till at least I know for sure? It just seems to me if u r both carriers how can your baby NOT have c.f? I just dont understand the gene thing very much. like i said we both have the same gene, my doc said that is odd but its true...does that mean anything diff? I wish everyone luck out there and would luv if u write back to me with some answers to help me out here...feel free to email me at mslorri2005@charter.net...............TY.....<img src="i/expressions/face-icon-small-confused.gif" border="0">
I am very confused with all of this. My husband has a son from a previous marriage that has CF.
I know that they had said in order for him to have it that the mother and the father have to be carriers of the gene. Well we now have a son together and I was wondering if he has a chance of being carrier or something?
I know that they had said in order for him to have it that the mother and the father have to be carriers of the gene. Well we now have a son together and I was wondering if he has a chance of being carrier or something?