If we get one mutation from each parent, and both parents are non-symptomatic carriers (that is they each carry only 1 mutation), then it would stand to reason that siblings who have CF (get both mutations) will have the identical mutation pair. Further reasoning, assuming identical environment, would conclude that the siblings have very similar experience and severity. I knew identical twins with CF, and they almost always had the same problems at the same times.
I am 53, but I had a brother about 1 year apart in age. He died at 3 months with very severe symptoms. He had a feeding tube from the beginning. I was diagnosed at the age of 6 months, but had a fairly healthy time through high school and college. No CPT and very rarely doing antibiotics or other meds. The more I think about it, the more curious I am as to why we had such different severities of CF.
I would appreciate other siblings sharing their experience, especially if you have different severity and experiences, and do you have any explanations for such.
I am 53, but I had a brother about 1 year apart in age. He died at 3 months with very severe symptoms. He had a feeding tube from the beginning. I was diagnosed at the age of 6 months, but had a fairly healthy time through high school and college. No CPT and very rarely doing antibiotics or other meds. The more I think about it, the more curious I am as to why we had such different severities of CF.
I would appreciate other siblings sharing their experience, especially if you have different severity and experiences, and do you have any explanations for such.