alcaligenes

A

angelrn00

New member
ok, the new germ brian has that we can't seem to get rid of is called alcaligenes. anyone ever heard of this?? in the hosp he was on coliston for 12 days and high dose oral bactrim. his pft went down a percent.... so just wondering if anyone else has had this germ and has had success getting rid of it. if so, would like to know what antibiotic regimine you were on. he was also on primaxin and cipro iv.
thanks!
 
A

angelrn00

New member
ok, the new germ brian has that we can't seem to get rid of is called alcaligenes. anyone ever heard of this?? in the hosp he was on coliston for 12 days and high dose oral bactrim. his pft went down a percent.... so just wondering if anyone else has had this germ and has had success getting rid of it. if so, would like to know what antibiotic regimine you were on. he was also on primaxin and cipro iv.
thanks!
 
A

angelrn00

New member
ok, the new germ brian has that we can't seem to get rid of is called alcaligenes. anyone ever heard of this?? in the hosp he was on coliston for 12 days and high dose oral bactrim. his pft went down a percent.... so just wondering if anyone else has had this germ and has had success getting rid of it. if so, would like to know what antibiotic regimine you were on. he was also on primaxin and cipro iv.
<br />thanks!
 
H

Havoc

New member
It's a gram-negative bacteria, but we don't know too much about it. Studies have been limited because of the difficulty in determining species of Alcaligenes (there are 5 but most commonly in CF is A. xylosoxidans). They are found in contaminated soil and water and also increasingly a nosocomial infection. Sometimes it is misdiagnosed as a non-aeruginosa strain of Pseudomonas.

Usually, they are susceptible to Bactim, the penenem's (Imipenem, Meropenem etc.), Ceftaz and sometimes really broad-spectrum penicillins. These are usually used in conjunction with a beta-lactamase inhibitor. A sensitivity study would be helpful information. It is difficult to get rid of.
 
H

Havoc

New member
It's a gram-negative bacteria, but we don't know too much about it. Studies have been limited because of the difficulty in determining species of Alcaligenes (there are 5 but most commonly in CF is A. xylosoxidans). They are found in contaminated soil and water and also increasingly a nosocomial infection. Sometimes it is misdiagnosed as a non-aeruginosa strain of Pseudomonas.

Usually, they are susceptible to Bactim, the penenem's (Imipenem, Meropenem etc.), Ceftaz and sometimes really broad-spectrum penicillins. These are usually used in conjunction with a beta-lactamase inhibitor. A sensitivity study would be helpful information. It is difficult to get rid of.
 
H

Havoc

New member
It's a gram-negative bacteria, but we don't know too much about it. Studies have been limited because of the difficulty in determining species of Alcaligenes (there are 5 but most commonly in CF is A. xylosoxidans). They are found in contaminated soil and water and also increasingly a nosocomial infection. Sometimes it is misdiagnosed as a non-aeruginosa strain of Pseudomonas.
<br />
<br />Usually, they are susceptible to Bactim, the penenem's (Imipenem, Meropenem etc.), Ceftaz and sometimes really broad-spectrum penicillins. These are usually used in conjunction with a beta-lactamase inhibitor. A sensitivity study would be helpful information. It is difficult to get rid of.
 
L

Lief

New member
I have Achromobacter Xylosoxidans.

Like Havoc said, it is very difficult to get rid of. It develops resistances to antibiotics quickly.

When I first cultured AX, I was given Bactrim (now resistant), and then later during hospital stays I was given ertapenem and imipenem.

**If I remember correctly the two work almost identically, I had one in the hospital for a few days and then a different one that I could take home. I think the deciding factor on what I would take home was just the price of it, although at the moment I can't remember which one I had where. lol.**

During my hospital stay I did get much better, however the following year my AX was resistant to all of the penem series.

The last few weeks I've been on Augmentin (a combination of Amoxicillin (b-lactam antibiotic) with potassium clavulanate (b-lactamase inhibitor)), which has seemed to work well.

b-lactam antibiotics and b-lactamase inhibitors are almost always used in treating Alcaligenes.
 
L

Lief

New member
I have Achromobacter Xylosoxidans.

Like Havoc said, it is very difficult to get rid of. It develops resistances to antibiotics quickly.

When I first cultured AX, I was given Bactrim (now resistant), and then later during hospital stays I was given ertapenem and imipenem.

**If I remember correctly the two work almost identically, I had one in the hospital for a few days and then a different one that I could take home. I think the deciding factor on what I would take home was just the price of it, although at the moment I can't remember which one I had where. lol.**

During my hospital stay I did get much better, however the following year my AX was resistant to all of the penem series.

The last few weeks I've been on Augmentin (a combination of Amoxicillin (b-lactam antibiotic) with potassium clavulanate (b-lactamase inhibitor)), which has seemed to work well.

b-lactam antibiotics and b-lactamase inhibitors are almost always used in treating Alcaligenes.
 
L

Lief

New member
I have Achromobacter Xylosoxidans.
<br />
<br />Like Havoc said, it is very difficult to get rid of. It develops resistances to antibiotics quickly.
<br />
<br />When I first cultured AX, I was given Bactrim (now resistant), and then later during hospital stays I was given ertapenem and imipenem.
<br />
<br />**If I remember correctly the two work almost identically, I had one in the hospital for a few days and then a different one that I could take home. I think the deciding factor on what I would take home was just the price of it, although at the moment I can't remember which one I had where. lol.**
<br />
<br />During my hospital stay I did get much better, however the following year my AX was resistant to all of the penem series.
<br />
<br />The last few weeks I've been on Augmentin (a combination of Amoxicillin (b-lactam antibiotic) with potassium clavulanate (b-lactamase inhibitor)), which has seemed to work well.
<br />
<br />b-lactam antibiotics and b-lactamase inhibitors are almost always used in treating Alcaligenes.
 
A

angelrn00

New member
gggrrrrr....lol. so Lief...you still have that bug and are still treating it? and Jonathan, do you have that germ too? brian has had it for over a year now and it has been awful!! It's like he just can't stay well now! I don't know if they just haven't gotten the right combo of meds, or what. he goes back to the dr on thurs, so i will write down these things that you both said and ask about those meds. i know he has been on the imepenum, and also bactrim. he only had about 2 days of bactrim though, because he started getting really itchy, so they stopped it completely???? i was thinking..give him some freakin benadryl and keep going!! lol. i don't know. Lief, have you had alot more "sick time" since having this stupid germ? jonathan, if you have it, same question. before this, b would get sick every 2 yrs or so...tolerable. but he's been in the hospital 2 times in the past yr and had 3 picc lines. we are both getting pretty frustrated. thanks for your help!
 
A

angelrn00

New member
gggrrrrr....lol. so Lief...you still have that bug and are still treating it? and Jonathan, do you have that germ too? brian has had it for over a year now and it has been awful!! It's like he just can't stay well now! I don't know if they just haven't gotten the right combo of meds, or what. he goes back to the dr on thurs, so i will write down these things that you both said and ask about those meds. i know he has been on the imepenum, and also bactrim. he only had about 2 days of bactrim though, because he started getting really itchy, so they stopped it completely???? i was thinking..give him some freakin benadryl and keep going!! lol. i don't know. Lief, have you had alot more "sick time" since having this stupid germ? jonathan, if you have it, same question. before this, b would get sick every 2 yrs or so...tolerable. but he's been in the hospital 2 times in the past yr and had 3 picc lines. we are both getting pretty frustrated. thanks for your help!
 
A

angelrn00

New member
gggrrrrr....lol. so Lief...you still have that bug and are still treating it? and Jonathan, do you have that germ too? brian has had it for over a year now and it has been awful!! It's like he just can't stay well now! I don't know if they just haven't gotten the right combo of meds, or what. he goes back to the dr on thurs, so i will write down these things that you both said and ask about those meds. i know he has been on the imepenum, and also bactrim. he only had about 2 days of bactrim though, because he started getting really itchy, so they stopped it completely???? i was thinking..give him some freakin benadryl and keep going!! lol. i don't know. Lief, have you had alot more "sick time" since having this stupid germ? jonathan, if you have it, same question. before this, b would get sick every 2 yrs or so...tolerable. but he's been in the hospital 2 times in the past yr and had 3 picc lines. we are both getting pretty frustrated. thanks for your help!
 
H

Havoc

New member
Angel,

I don't have A. xylosoxidans, luckily. At least his strain seems to still be sensitive to the penem's.
 
H

Havoc

New member
Angel,

I don't have A. xylosoxidans, luckily. At least his strain seems to still be sensitive to the penem's.
 
H

Havoc

New member
Angel,
<br />
<br />I don't have A. xylosoxidans, luckily. At least his strain seems to still be sensitive to the penem's.
 
L

Lief

New member
My health has been pretty good.

I've cultured AX since the end of 2001 and it was never a huge problem. The only time I seemed to get sick was when I had other infections (StaphA, pneumonia, etc.) I wouldn't attribute my AX as the main reason of any sicknesses I had. In fact, I had sinus surgery in 2003 and was hospital free for about 6 years.

I was hospitalized in 2009 because, for whatever reason, (luck I guess) I was hit with several infections all at once. My AX grew resistances to the antibiotics I was on, my Staph A. started to rapidly grow, and I also ended up with pneumonia.

All of those at once was something my body couldn't handle so I was pretty sick. (They thought I had swine-flu initially I was doing so badly. PFT's dropped 20~%.) I did make a recovery, however. Although, ever since then, my PFTs have hovered in the mid 70's/high 60s.(It used to be around 90-80%). Although again, I wouldn't consider my AX the main cause of my PFT drop.

I've been pretty healthy since, with the exception of these past few weeks (I'm back to baseline now after the Augmentin).

I've cultured multiple strands of AX (some at the same time) ever since 2001. It has never been eradicated and my doctor told me that most likely I'll have remnants of it for the rest of my life.

I don't want to sound discouraging or anything.. but as we have said.. its a pretty stubborn bug. lol
 
L

Lief

New member
My health has been pretty good.

I've cultured AX since the end of 2001 and it was never a huge problem. The only time I seemed to get sick was when I had other infections (StaphA, pneumonia, etc.) I wouldn't attribute my AX as the main reason of any sicknesses I had. In fact, I had sinus surgery in 2003 and was hospital free for about 6 years.

I was hospitalized in 2009 because, for whatever reason, (luck I guess) I was hit with several infections all at once. My AX grew resistances to the antibiotics I was on, my Staph A. started to rapidly grow, and I also ended up with pneumonia.

All of those at once was something my body couldn't handle so I was pretty sick. (They thought I had swine-flu initially I was doing so badly. PFT's dropped 20~%.) I did make a recovery, however. Although, ever since then, my PFTs have hovered in the mid 70's/high 60s.(It used to be around 90-80%). Although again, I wouldn't consider my AX the main cause of my PFT drop.

I've been pretty healthy since, with the exception of these past few weeks (I'm back to baseline now after the Augmentin).

I've cultured multiple strands of AX (some at the same time) ever since 2001. It has never been eradicated and my doctor told me that most likely I'll have remnants of it for the rest of my life.

I don't want to sound discouraging or anything.. but as we have said.. its a pretty stubborn bug. lol
 
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