An update

J

Jem

New member
Hey Sean!<img src="i/expressions/face-icon-small-happy.gif" border="0"> I miss your humor and candor as well. Thanks for the inspiring post. Your PFT'S are amazing...way to go!

I too love the vest (inCourage) and am addicted to doing it with the hypertonic saline as it really makes my chest feel clear.

Please don't be a stranger around here or at least check in more often. Looking forward to your next post.<img src="i/expressions/face-icon-small-wink.gif" border="0">
 
J

Jem

New member
Hey Sean!<img src="i/expressions/face-icon-small-happy.gif" border="0"> I miss your humor and candor as well. Thanks for the inspiring post. Your PFT'S are amazing...way to go!

I too love the vest (inCourage) and am addicted to doing it with the hypertonic saline as it really makes my chest feel clear.

Please don't be a stranger around here or at least check in more often. Looking forward to your next post.<img src="i/expressions/face-icon-small-wink.gif" border="0">
 
D

dramamama

New member
Hi Sean Davis-

Thanks for letting us know how you are doing!!! Just wanted to post this about high dose fish oil having deleterious effects on cf....might want to take it easy on high doses!!

take care.
mandy

J Cyst Fibros. 2007 Jan 24; [Epub ahead of print]
> Links
> Fatty acids platelets and oxidative markers
> following
> intravenous n-3 fatty acids administration in cystic
> fibrosis: An open pilot observational study.
>
> Durieu I, Vericel E, Guichardant D, Roth H, Steghens
> JP, Drai J, Nove Josserand R, Fontaine E, Lagarde M,
> Bellon G.
> Department of Internal Medicine and Cystic Fibrosis
> Adult Center, University Claude Bernard Lyon 1,
> Centre
> Hospitalier Lyon-Sud, 69495 Pierre-Benite cedex,
> France.
> BACKGROUND: An imbalance in the ratio of arachidonic
> acid and docosahexaenoic acid (DHA) was found in
> cystic fibrosis (CF) affected tissues and was
> suggested to promote inflammation. Several studies
> have shown that the long chain n-3 fatty acids
> reduced
> inflammatory activity while others have highlighted
> prooxidant activity of DHA at high concentrations.
> The
> aim of our study was to evaluate the effects of an
> intravenous fish-oil emulsion enriched with n-3 FA
> in
> patients with CF on plasma and platelet FA
> composition
> and peroxidation markers. METHODS: 13 patients with
> CF
> received one IV emulsion per week of 2 mL/kg
> fish-oil
> n-3 emulsion for 12 weeks. RESULTS: There was a
> significant increase in 20:5 n-3 and 22:6 n-3
> platelet
> FA composition, no variation in 20:4 n-6, a decrease
> in n-9. There was no variation in plasma FA
> composition. Specific urinary markers of lipid
> peroxidation derived from n-3 and n-6 showed a very
> high level before infusion compared with usual
> values
> in healthy subjects which was not affected by
> treatment. A significant weight loss and a decrease
> in
> reduced glutathione were observed in adult patients.
> CONCLUSIONS: The intravenous administration of n-3
> FA
> in CF patients induced a significant modification in
> platelet FA composition but no modification of
> oxidative markers.<b> However, the weight loss and the
> decreased level in reduced glutathione observed in
> adult patients may suggest a potential deleterious
> activity for some patients.</b> Further studies are
> necessary to determine the optimal dose and route
> for
> long chain FA administration required to reach a
> potential beneficial effect.
>
 
D

dramamama

New member
Hi Sean Davis-

Thanks for letting us know how you are doing!!! Just wanted to post this about high dose fish oil having deleterious effects on cf....might want to take it easy on high doses!!

take care.
mandy

J Cyst Fibros. 2007 Jan 24; [Epub ahead of print]
> Links
> Fatty acids platelets and oxidative markers
> following
> intravenous n-3 fatty acids administration in cystic
> fibrosis: An open pilot observational study.
>
> Durieu I, Vericel E, Guichardant D, Roth H, Steghens
> JP, Drai J, Nove Josserand R, Fontaine E, Lagarde M,
> Bellon G.
> Department of Internal Medicine and Cystic Fibrosis
> Adult Center, University Claude Bernard Lyon 1,
> Centre
> Hospitalier Lyon-Sud, 69495 Pierre-Benite cedex,
> France.
> BACKGROUND: An imbalance in the ratio of arachidonic
> acid and docosahexaenoic acid (DHA) was found in
> cystic fibrosis (CF) affected tissues and was
> suggested to promote inflammation. Several studies
> have shown that the long chain n-3 fatty acids
> reduced
> inflammatory activity while others have highlighted
> prooxidant activity of DHA at high concentrations.
> The
> aim of our study was to evaluate the effects of an
> intravenous fish-oil emulsion enriched with n-3 FA
> in
> patients with CF on plasma and platelet FA
> composition
> and peroxidation markers. METHODS: 13 patients with
> CF
> received one IV emulsion per week of 2 mL/kg
> fish-oil
> n-3 emulsion for 12 weeks. RESULTS: There was a
> significant increase in 20:5 n-3 and 22:6 n-3
> platelet
> FA composition, no variation in 20:4 n-6, a decrease
> in n-9. There was no variation in plasma FA
> composition. Specific urinary markers of lipid
> peroxidation derived from n-3 and n-6 showed a very
> high level before infusion compared with usual
> values
> in healthy subjects which was not affected by
> treatment. A significant weight loss and a decrease
> in
> reduced glutathione were observed in adult patients.
> CONCLUSIONS: The intravenous administration of n-3
> FA
> in CF patients induced a significant modification in
> platelet FA composition but no modification of
> oxidative markers.<b> However, the weight loss and the
> decreased level in reduced glutathione observed in
> adult patients may suggest a potential deleterious
> activity for some patients.</b> Further studies are
> necessary to determine the optimal dose and route
> for
> long chain FA administration required to reach a
> potential beneficial effect.
>
 
D

dramamama

New member
Hi Sean Davis-

Thanks for letting us know how you are doing!!! Just wanted to post this about high dose fish oil having deleterious effects on cf....might want to take it easy on high doses!!

take care.
mandy

J Cyst Fibros. 2007 Jan 24; [Epub ahead of print]
> Links
> Fatty acids platelets and oxidative markers
> following
> intravenous n-3 fatty acids administration in cystic
> fibrosis: An open pilot observational study.
>
> Durieu I, Vericel E, Guichardant D, Roth H, Steghens
> JP, Drai J, Nove Josserand R, Fontaine E, Lagarde M,
> Bellon G.
> Department of Internal Medicine and Cystic Fibrosis
> Adult Center, University Claude Bernard Lyon 1,
> Centre
> Hospitalier Lyon-Sud, 69495 Pierre-Benite cedex,
> France.
> BACKGROUND: An imbalance in the ratio of arachidonic
> acid and docosahexaenoic acid (DHA) was found in
> cystic fibrosis (CF) affected tissues and was
> suggested to promote inflammation. Several studies
> have shown that the long chain n-3 fatty acids
> reduced
> inflammatory activity while others have highlighted
> prooxidant activity of DHA at high concentrations.
> The
> aim of our study was to evaluate the effects of an
> intravenous fish-oil emulsion enriched with n-3 FA
> in
> patients with CF on plasma and platelet FA
> composition
> and peroxidation markers. METHODS: 13 patients with
> CF
> received one IV emulsion per week of 2 mL/kg
> fish-oil
> n-3 emulsion for 12 weeks. RESULTS: There was a
> significant increase in 20:5 n-3 and 22:6 n-3
> platelet
> FA composition, no variation in 20:4 n-6, a decrease
> in n-9. There was no variation in plasma FA
> composition. Specific urinary markers of lipid
> peroxidation derived from n-3 and n-6 showed a very
> high level before infusion compared with usual
> values
> in healthy subjects which was not affected by
> treatment. A significant weight loss and a decrease
> in
> reduced glutathione were observed in adult patients.
> CONCLUSIONS: The intravenous administration of n-3
> FA
> in CF patients induced a significant modification in
> platelet FA composition but no modification of
> oxidative markers.<b> However, the weight loss and the
> decreased level in reduced glutathione observed in
> adult patients may suggest a potential deleterious
> activity for some patients.</b> Further studies are
> necessary to determine the optimal dose and route
> for
> long chain FA administration required to reach a
> potential beneficial effect.
>
 
D

dramamama

New member
Hi Sean Davis-

Thanks for letting us know how you are doing!!! Just wanted to post this about high dose fish oil having deleterious effects on cf....might want to take it easy on high doses!!

take care.
mandy

J Cyst Fibros. 2007 Jan 24; [Epub ahead of print]
> Links
> Fatty acids platelets and oxidative markers
> following
> intravenous n-3 fatty acids administration in cystic
> fibrosis: An open pilot observational study.
>
> Durieu I, Vericel E, Guichardant D, Roth H, Steghens
> JP, Drai J, Nove Josserand R, Fontaine E, Lagarde M,
> Bellon G.
> Department of Internal Medicine and Cystic Fibrosis
> Adult Center, University Claude Bernard Lyon 1,
> Centre
> Hospitalier Lyon-Sud, 69495 Pierre-Benite cedex,
> France.
> BACKGROUND: An imbalance in the ratio of arachidonic
> acid and docosahexaenoic acid (DHA) was found in
> cystic fibrosis (CF) affected tissues and was
> suggested to promote inflammation. Several studies
> have shown that the long chain n-3 fatty acids
> reduced
> inflammatory activity while others have highlighted
> prooxidant activity of DHA at high concentrations.
> The
> aim of our study was to evaluate the effects of an
> intravenous fish-oil emulsion enriched with n-3 FA
> in
> patients with CF on plasma and platelet FA
> composition
> and peroxidation markers. METHODS: 13 patients with
> CF
> received one IV emulsion per week of 2 mL/kg
> fish-oil
> n-3 emulsion for 12 weeks. RESULTS: There was a
> significant increase in 20:5 n-3 and 22:6 n-3
> platelet
> FA composition, no variation in 20:4 n-6, a decrease
> in n-9. There was no variation in plasma FA
> composition. Specific urinary markers of lipid
> peroxidation derived from n-3 and n-6 showed a very
> high level before infusion compared with usual
> values
> in healthy subjects which was not affected by
> treatment. A significant weight loss and a decrease
> in
> reduced glutathione were observed in adult patients.
> CONCLUSIONS: The intravenous administration of n-3
> FA
> in CF patients induced a significant modification in
> platelet FA composition but no modification of
> oxidative markers.<b> However, the weight loss and the
> decreased level in reduced glutathione observed in
> adult patients may suggest a potential deleterious
> activity for some patients.</b> Further studies are
> necessary to determine the optimal dose and route
> for
> long chain FA administration required to reach a
> potential beneficial effect.
>
 
D

dramamama

New member
Hi Sean Davis-

Thanks for letting us know how you are doing!!! Just wanted to post this about high dose fish oil having deleterious effects on cf....might want to take it easy on high doses!!

take care.
mandy

J Cyst Fibros. 2007 Jan 24; [Epub ahead of print]
> Links
> Fatty acids platelets and oxidative markers
> following
> intravenous n-3 fatty acids administration in cystic
> fibrosis: An open pilot observational study.
>
> Durieu I, Vericel E, Guichardant D, Roth H, Steghens
> JP, Drai J, Nove Josserand R, Fontaine E, Lagarde M,
> Bellon G.
> Department of Internal Medicine and Cystic Fibrosis
> Adult Center, University Claude Bernard Lyon 1,
> Centre
> Hospitalier Lyon-Sud, 69495 Pierre-Benite cedex,
> France.
> BACKGROUND: An imbalance in the ratio of arachidonic
> acid and docosahexaenoic acid (DHA) was found in
> cystic fibrosis (CF) affected tissues and was
> suggested to promote inflammation. Several studies
> have shown that the long chain n-3 fatty acids
> reduced
> inflammatory activity while others have highlighted
> prooxidant activity of DHA at high concentrations.
> The
> aim of our study was to evaluate the effects of an
> intravenous fish-oil emulsion enriched with n-3 FA
> in
> patients with CF on plasma and platelet FA
> composition
> and peroxidation markers. METHODS: 13 patients with
> CF
> received one IV emulsion per week of 2 mL/kg
> fish-oil
> n-3 emulsion for 12 weeks. RESULTS: There was a
> significant increase in 20:5 n-3 and 22:6 n-3
> platelet
> FA composition, no variation in 20:4 n-6, a decrease
> in n-9. There was no variation in plasma FA
> composition. Specific urinary markers of lipid
> peroxidation derived from n-3 and n-6 showed a very
> high level before infusion compared with usual
> values
> in healthy subjects which was not affected by
> treatment. A significant weight loss and a decrease
> in
> reduced glutathione were observed in adult patients.
> CONCLUSIONS: The intravenous administration of n-3
> FA
> in CF patients induced a significant modification in
> platelet FA composition but no modification of
> oxidative markers.<b> However, the weight loss and the
> decreased level in reduced glutathione observed in
> adult patients may suggest a potential deleterious
> activity for some patients.</b> Further studies are
> necessary to determine the optimal dose and route
> for
> long chain FA administration required to reach a
> potential beneficial effect.
>
 
D

dramamama

New member
Hi Sean Davis-

Thanks for letting us know how you are doing!!! Just wanted to post this about high dose fish oil having deleterious effects on cf....might want to take it easy on high doses!!

take care.
mandy

J Cyst Fibros. 2007 Jan 24; [Epub ahead of print]
> Links
> Fatty acids platelets and oxidative markers
> following
> intravenous n-3 fatty acids administration in cystic
> fibrosis: An open pilot observational study.
>
> Durieu I, Vericel E, Guichardant D, Roth H, Steghens
> JP, Drai J, Nove Josserand R, Fontaine E, Lagarde M,
> Bellon G.
> Department of Internal Medicine and Cystic Fibrosis
> Adult Center, University Claude Bernard Lyon 1,
> Centre
> Hospitalier Lyon-Sud, 69495 Pierre-Benite cedex,
> France.
> BACKGROUND: An imbalance in the ratio of arachidonic
> acid and docosahexaenoic acid (DHA) was found in
> cystic fibrosis (CF) affected tissues and was
> suggested to promote inflammation. Several studies
> have shown that the long chain n-3 fatty acids
> reduced
> inflammatory activity while others have highlighted
> prooxidant activity of DHA at high concentrations.
> The
> aim of our study was to evaluate the effects of an
> intravenous fish-oil emulsion enriched with n-3 FA
> in
> patients with CF on plasma and platelet FA
> composition
> and peroxidation markers. METHODS: 13 patients with
> CF
> received one IV emulsion per week of 2 mL/kg
> fish-oil
> n-3 emulsion for 12 weeks. RESULTS: There was a
> significant increase in 20:5 n-3 and 22:6 n-3
> platelet
> FA composition, no variation in 20:4 n-6, a decrease
> in n-9. There was no variation in plasma FA
> composition. Specific urinary markers of lipid
> peroxidation derived from n-3 and n-6 showed a very
> high level before infusion compared with usual
> values
> in healthy subjects which was not affected by
> treatment. A significant weight loss and a decrease
> in
> reduced glutathione were observed in adult patients.
> CONCLUSIONS: The intravenous administration of n-3
> FA
> in CF patients induced a significant modification in
> platelet FA composition but no modification of
> oxidative markers.<b> However, the weight loss and the
> decreased level in reduced glutathione observed in
> adult patients may suggest a potential deleterious
> activity for some patients.</b> Further studies are
> necessary to determine the optimal dose and route
> for
> long chain FA administration required to reach a
> potential beneficial effect.
>
 
K

kayleesgrandma

New member
Whoo hoo, the man is back!!! *Stands in front of cement truck with muscled arms on hips, and cape flowing behind him...* Glad to see you! I will never forget all the info about oregano oil you gave us *back in the day--I've missed you. You have always been honest with how you took care of yourself, and it's great that you told about your "slacking off". Getting back to training and taking care of yourself has sure produced good results--it's great of you to share. That's what you always brought to the site (besides your bizare sense of humor)--honesty and sincerity in your healthcare, along with a willingness to experiment.

Thanks for "flying" in and letting us hear from you. Now off to infinity and beyond...
 
K

kayleesgrandma

New member
Whoo hoo, the man is back!!! *Stands in front of cement truck with muscled arms on hips, and cape flowing behind him...* Glad to see you! I will never forget all the info about oregano oil you gave us *back in the day--I've missed you. You have always been honest with how you took care of yourself, and it's great that you told about your "slacking off". Getting back to training and taking care of yourself has sure produced good results--it's great of you to share. That's what you always brought to the site (besides your bizare sense of humor)--honesty and sincerity in your healthcare, along with a willingness to experiment.

Thanks for "flying" in and letting us hear from you. Now off to infinity and beyond...
 
K

kayleesgrandma

New member
Whoo hoo, the man is back!!! *Stands in front of cement truck with muscled arms on hips, and cape flowing behind him...* Glad to see you! I will never forget all the info about oregano oil you gave us *back in the day--I've missed you. You have always been honest with how you took care of yourself, and it's great that you told about your "slacking off". Getting back to training and taking care of yourself has sure produced good results--it's great of you to share. That's what you always brought to the site (besides your bizare sense of humor)--honesty and sincerity in your healthcare, along with a willingness to experiment.

Thanks for "flying" in and letting us hear from you. Now off to infinity and beyond...
 
K

kayleesgrandma

New member
Whoo hoo, the man is back!!! *Stands in front of cement truck with muscled arms on hips, and cape flowing behind him...* Glad to see you! I will never forget all the info about oregano oil you gave us *back in the day--I've missed you. You have always been honest with how you took care of yourself, and it's great that you told about your "slacking off". Getting back to training and taking care of yourself has sure produced good results--it's great of you to share. That's what you always brought to the site (besides your bizare sense of humor)--honesty and sincerity in your healthcare, along with a willingness to experiment.

Thanks for "flying" in and letting us hear from you. Now off to infinity and beyond...
 
K

kayleesgrandma

New member
Whoo hoo, the man is back!!! *Stands in front of cement truck with muscled arms on hips, and cape flowing behind him...* Glad to see you! I will never forget all the info about oregano oil you gave us *back in the day--I've missed you. You have always been honest with how you took care of yourself, and it's great that you told about your "slacking off". Getting back to training and taking care of yourself has sure produced good results--it's great of you to share. That's what you always brought to the site (besides your bizare sense of humor)--honesty and sincerity in your healthcare, along with a willingness to experiment.

Thanks for "flying" in and letting us hear from you. Now off to infinity and beyond...
 
K

kayleesgrandma

New member
Whoo hoo, the man is back!!! *Stands in front of cement truck with muscled arms on hips, and cape flowing behind him...* Glad to see you! I will never forget all the info about oregano oil you gave us *back in the day--I've missed you. You have always been honest with how you took care of yourself, and it's great that you told about your "slacking off". Getting back to training and taking care of yourself has sure produced good results--it's great of you to share. That's what you always brought to the site (besides your bizare sense of humor)--honesty and sincerity in your healthcare, along with a willingness to experiment.

Thanks for "flying" in and letting us hear from you. Now off to infinity and beyond...
 
S

Sakem

New member
Glad you are doing so well......I think supplements can be harmful sometimes to CFers. Too much of anything, is not always the best. Plus with supplements, being unregulated, I;m leary of putting all this stuff in my body....even NAC, no one knows for sure if this is harmless, or could too much be the cause of streaking in lungs
 
S

Sakem

New member
Glad you are doing so well......I think supplements can be harmful sometimes to CFers. Too much of anything, is not always the best. Plus with supplements, being unregulated, I;m leary of putting all this stuff in my body....even NAC, no one knows for sure if this is harmless, or could too much be the cause of streaking in lungs
 
S

Sakem

New member
Glad you are doing so well......I think supplements can be harmful sometimes to CFers. Too much of anything, is not always the best. Plus with supplements, being unregulated, I;m leary of putting all this stuff in my body....even NAC, no one knows for sure if this is harmless, or could too much be the cause of streaking in lungs
 
S

Sakem

New member
Glad you are doing so well......I think supplements can be harmful sometimes to CFers. Too much of anything, is not always the best. Plus with supplements, being unregulated, I;m leary of putting all this stuff in my body....even NAC, no one knows for sure if this is harmless, or could too much be the cause of streaking in lungs
 
S

Sakem

New member
Glad you are doing so well......I think supplements can be harmful sometimes to CFers. Too much of anything, is not always the best. Plus with supplements, being unregulated, I;m leary of putting all this stuff in my body....even NAC, no one knows for sure if this is harmless, or could too much be the cause of streaking in lungs
 
S

Sakem

New member
Glad you are doing so well......I think supplements can be harmful sometimes to CFers. Too much of anything, is not always the best. Plus with supplements, being unregulated, I;m leary of putting all this stuff in my body....even NAC, no one knows for sure if this is harmless, or could too much be the cause of streaking in lungs
 
You must log in or register to reply here.
Top