Anybody Try Curcumin and Quercetin?

2

2roses

New member
Has anybody tried using curcumin and quercetin supplements with any success? I have an acquaintance who keeps suggesting this for my kids and I see that there was some research done in 2004 (this acquaintance is a 50yo with health problems and NOT CF). I'm not finding anything current, though. I'm always concerned about trying something new when the kids are on so many medications already.
Would love to hear from you all.
Thanks,
Sherri
 
2

2roses

New member
Has anybody tried using curcumin and quercetin supplements with any success? I have an acquaintance who keeps suggesting this for my kids and I see that there was some research done in 2004 (this acquaintance is a 50yo with health problems and NOT CF). I'm not finding anything current, though. I'm always concerned about trying something new when the kids are on so many medications already.
Would love to hear from you all.
Thanks,
Sherri
 
H

Havoc

New member
You are correct, there were some studies done with curcumin and inflammation. The last word I heard on the matter was that you had to take the curcumin in such a high dose to have an effect, it would be impractical. I have also heard anecdotes linking high-dose curcumin to cancer, but I have not personally read any studies suggesting that. I applaud your desire to investigate things fully before starting treatment. Hopefully others who followed that study more closely will weigh in.
 
H

Havoc

New member
You are correct, there were some studies done with curcumin and inflammation. The last word I heard on the matter was that you had to take the curcumin in such a high dose to have an effect, it would be impractical. I have also heard anecdotes linking high-dose curcumin to cancer, but I have not personally read any studies suggesting that. I applaud your desire to investigate things fully before starting treatment. Hopefully others who followed that study more closely will weigh in.
 
2

2roses

New member
I haven't been on the forum for awhile. Thanks for getting back to me, Jonathan! As you know, so many people try to "help" when they really don't know what goes on with CF and how complex the disease--and the meds--are. I hope others will post if they know anything about curcumin/quercitin, but probably not since this is already a dated post. Thanks, though. I appreciate reading your responses...always great insight from you.
 
2

2roses

New member
I haven't been on the forum for awhile. Thanks for getting back to me, Jonathan! As you know, so many people try to "help" when they really don't know what goes on with CF and how complex the disease--and the meds--are. I hope others will post if they know anything about curcumin/quercitin, but probably not since this is already a dated post. Thanks, though. I appreciate reading your responses...always great insight from you.
 
M

markbrave

New member
Hi 2roses,

we tried both curcumin and quercetin. We noticed positive effects in both cases: improved fat absorbtion and digestion to the level that we needed to lower the CREON dosage. Quercetin was definitively stronger.
We stopped curcumin because our doctor said that it may impact the liver with high dosage.
Quercetin worked better with natural substances like Roibos or red tea and it does not have the side effects of curcumin. Please, consult a doctor to calculate the proper dosage. Quercetin is not toxic but any natural substance with very high dosage may create problems with the kidneys.

Quercetin works better with DDF508. It could be less beneficial with other mutations.
Some scientific references. Some very recent:

Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of ?F508 cystic fibrosis transmembrane conductance regulator rescue
http://www.ncbi.nlm.nih.gov/pubmed/20042712

Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells.
http://www.ncbi.nlm.nih.gov/pubmed/21782406

Evaluation of the potential in vivo genotoxicity of quercetin.
http://www.ncbi.nlm.nih.gov/pubmed/18556240

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties.
http://www.ncbi.nlm.nih.gov/pubmed/17698276

Quercetin: A potential drug to reverse multidrug resistance
http://www.ncbi.nlm.nih.gov/pubmed/20637779

Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: a model experiment.
http://www.ncbi.nlm.nih.gov/pubmed/18586279

-----------
father of a beautiful CF girl (DDF508) and strong believer in natural remedies for CF
 
M

markbrave

New member
Hi 2roses,

we tried both curcumin and quercetin. We noticed positive effects in both cases: improved fat absorbtion and digestion to the level that we needed to lower the CREON dosage. Quercetin was definitively stronger.
We stopped curcumin because our doctor said that it may impact the liver with high dosage.
Quercetin worked better with natural substances like Roibos or red tea and it does not have the side effects of curcumin. Please, consult a doctor to calculate the proper dosage. Quercetin is not toxic but any natural substance with very high dosage may create problems with the kidneys.

Quercetin works better with DDF508. It could be less beneficial with other mutations.
Some scientific references. Some very recent:

Activation of the cystic fibrosis transmembrane conductance regulator by the flavonoid quercetin: potential use as a biomarker of ?F508 cystic fibrosis transmembrane conductance regulator rescue
http://www.ncbi.nlm.nih.gov/pubmed/20042712

Quercetin accumulates in nuclear structures and triggers specific gene expression in epithelial cells.
http://www.ncbi.nlm.nih.gov/pubmed/21782406

Evaluation of the potential in vivo genotoxicity of quercetin.
http://www.ncbi.nlm.nih.gov/pubmed/18556240

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties.
http://www.ncbi.nlm.nih.gov/pubmed/17698276

Quercetin: A potential drug to reverse multidrug resistance
http://www.ncbi.nlm.nih.gov/pubmed/20637779

Possible use of quercetin, an antioxidant, for protection of cells suffering from overload of intracellular Ca2+: a model experiment.
http://www.ncbi.nlm.nih.gov/pubmed/18586279

-----------
father of a beautiful CF girl (DDF508) and strong believer in natural remedies for CF
 
Y

ymikhale

New member
I trtied curcumin Ith my dd. I gav her the real substanc (not the pills or supplements). Did not see any effects on respiratory systemm She is PS, so can't comment on that
 
Y

ymikhale

New member
I trtied curcumin Ith my dd. I gav her the real substanc (not the pills or supplements). Did not see any effects on respiratory systemm She is PS, so can't comment on that
 
You must log in or register to reply here.
Top