Carriers

G

gunelle

Guest
Hi all,

I have a question about carriers. My mother and father are both are carriers, thus I have CF. My brothers (I have three) have not been tested yet, and they all have children. If one of my brohters is a carrier, and their partner is not, can their child then be a carrier?

Thanks for answering <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
G

gunelle

Guest
Hi all,

I have a question about carriers. My mother and father are both are carriers, thus I have CF. My brothers (I have three) have not been tested yet, and they all have children. If one of my brohters is a carrier, and their partner is not, can their child then be a carrier?

Thanks for answering <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
G

gunelle

Guest
Hi all,

I have a question about carriers. My mother and father are both are carriers, thus I have CF. My brothers (I have three) have not been tested yet, and they all have children. If one of my brohters is a carrier, and their partner is not, can their child then be a carrier?

Thanks for answering <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
G

gunelle

Guest
Hi all,

I have a question about carriers. My mother and father are both are carriers, thus I have CF. My brothers (I have three) have not been tested yet, and they all have children. If one of my brohters is a carrier, and their partner is not, can their child then be a carrier?

Thanks for answering <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
G

gunelle

Guest
Hi all,
<br />
<br />I have a question about carriers. My mother and father are both are carriers, thus I have CF. My brothers (I have three) have not been tested yet, and they all have children. If one of my brohters is a carrier, and their partner is not, can their child then be a carrier?
<br />
<br />Thanks for answering <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
M

Melissa75

Administrator
There is a 50% chance each of your siblings is a carrier, 25% not a carrier, and 25% has CF.
A carrier has a 50/50 chance of passing their CF mutation to their children.

Here is a helpful picture that refers to Huntington's disease, but useful to understand nonetheless. It shows a carrier with a non-carrier. You probably don't know if your brothers' spouses are carriers or not, so the 50/50 assurance is just hypothetical.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.bbc.co.uk/schools/gcsebitesize/science/images/aqaaddsci_17.gif">http://www.bbc.co.uk/schools/g...mages/aqaaddsci_17.gif</a>
 
M

Melissa75

Administrator
There is a 50% chance each of your siblings is a carrier, 25% not a carrier, and 25% has CF.
A carrier has a 50/50 chance of passing their CF mutation to their children.

Here is a helpful picture that refers to Huntington's disease, but useful to understand nonetheless. It shows a carrier with a non-carrier. You probably don't know if your brothers' spouses are carriers or not, so the 50/50 assurance is just hypothetical.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.bbc.co.uk/schools/gcsebitesize/science/images/aqaaddsci_17.gif">http://www.bbc.co.uk/schools/g...mages/aqaaddsci_17.gif</a>
 
M

Melissa75

Administrator
There is a 50% chance each of your siblings is a carrier, 25% not a carrier, and 25% has CF.
A carrier has a 50/50 chance of passing their CF mutation to their children.

Here is a helpful picture that refers to Huntington's disease, but useful to understand nonetheless. It shows a carrier with a non-carrier. You probably don't know if your brothers' spouses are carriers or not, so the 50/50 assurance is just hypothetical.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.bbc.co.uk/schools/gcsebitesize/science/images/aqaaddsci_17.gif">http://www.bbc.co.uk/schools/g...mages/aqaaddsci_17.gif</a>
 
M

Melissa75

Administrator
There is a 50% chance each of your siblings is a carrier, 25% not a carrier, and 25% has CF.
A carrier has a 50/50 chance of passing their CF mutation to their children.

Here is a helpful picture that refers to Huntington's disease, but useful to understand nonetheless. It shows a carrier with a non-carrier. You probably don't know if your brothers' spouses are carriers or not, so the 50/50 assurance is just hypothetical.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.bbc.co.uk/schools/gcsebitesize/science/images/aqaaddsci_17.gif">http://www.bbc.co.uk/schools/g...mages/aqaaddsci_17.gif</a>
 
M

Melissa75

Administrator
There is a 50% chance each of your siblings is a carrier, 25% not a carrier, and 25% has CF.
<br />A carrier has a 50/50 chance of passing their CF mutation to their children.
<br />
<br />Here is a helpful picture that refers to Huntington's disease, but useful to understand nonetheless. It shows a carrier with a non-carrier. You probably don't know if your brothers' spouses are carriers or not, so the 50/50 assurance is just hypothetical.
<br />
<br /><a target=_blank class=ftalternatingbarlinklarge href="http://www.bbc.co.uk/schools/gcsebitesize/science/images/aqaaddsci_17.gif">http://www.bbc.co.uk/schools/g...mages/aqaaddsci_17.gif</a>
 
H

hmw

New member
Yes. If your sib is a carrier, their children may be as well, since it only takes one mutation to be a carrier. There is a 50% chance that a carrier will pass their mutated gene to any child they have.
 
H

hmw

New member
Yes. If your sib is a carrier, their children may be as well, since it only takes one mutation to be a carrier. There is a 50% chance that a carrier will pass their mutated gene to any child they have.
 
H

hmw

New member
Yes. If your sib is a carrier, their children may be as well, since it only takes one mutation to be a carrier. There is a 50% chance that a carrier will pass their mutated gene to any child they have.
 
H

hmw

New member
Yes. If your sib is a carrier, their children may be as well, since it only takes one mutation to be a carrier. There is a 50% chance that a carrier will pass their mutated gene to any child they have.
 
H

hmw

New member
Yes. If your sib is a carrier, their children may be as well, since it only takes one mutation to be a carrier. There is a 50% chance that a carrier will pass their mutated gene to any child they have.
 
C

Cherylwithone

Guest
This is from the Cystic Fibrosis Foundation in the US.
I hope it helps


How does someone inherit a mutation of the CF gene?

People inherit genes from their parents. To have CF, a child must inherit one copy of a mutation of the CF gene from each parent. In other words, the child must have two copies of the defective gene to have CF. They could have two copies of one CF mutation, or have a copy of one CF mutation and a copy of another CF mutation.

A person who has only one copy of one mutation does not have CF and is considered a "carrier" of the CF gene. Both males and females can have the disease.

back to top

What does a positive genetic carrier test for CF mean?

A "positive" genetic carrier test for CF means that a person has a mutation of the CF gene; this result is more than 99 percent accurate. A "negative" carrier test result is not as accurate. With more than 1,000 different mutations of the CF gene, there are some rare ones that the test does not identify. Thus, if your test is negative for a mutation of the CF gene, there is still a small chance you could be a carrier of one of the rare mutations. This chance depends on your race or ethnic group and the type of genetic carrier test you receive.

back to top

If I have one copy of the defective CF gene, can my children have CF?

Yes. If you have one copy of a CF gene mutation, your child may have CF. However, your child will only have CF if your partner also is a carrier of a CF gene mutation. If you are both carriers, each child you have together has a 25 percent chance of having CF. If one partner is a carrier and the other partner's test result is negative for a CF gene mutation (or if there is no information on whether or not he or she carries the defective gene), there is still a slight chance the child could have CF. Your doctor or a genetic counselor can tell you about your individual chances of having a child with CF.

back to top

How does CF "appear" when no one in my family has ever had the disease?

Since having one copy of the defective CF gene does not cause symptoms, this copy can be passed down to family members without any impact on their health. Unless they have a child with CF, most people who are carriers of the gene do not know it.

Once parents have a child diagnosed with CF, all of their children should be tested for the disease, whether they are showing symptoms or not. Other relatives also have a chance of being CF carriers and may wish to get a genetic carrier test for CF, or they may wish to be given the sweat test if they are showing symptoms of CF.

back to top
 
C

Cherylwithone

Guest
This is from the Cystic Fibrosis Foundation in the US.
I hope it helps


How does someone inherit a mutation of the CF gene?

People inherit genes from their parents. To have CF, a child must inherit one copy of a mutation of the CF gene from each parent. In other words, the child must have two copies of the defective gene to have CF. They could have two copies of one CF mutation, or have a copy of one CF mutation and a copy of another CF mutation.

A person who has only one copy of one mutation does not have CF and is considered a "carrier" of the CF gene. Both males and females can have the disease.

back to top

What does a positive genetic carrier test for CF mean?

A "positive" genetic carrier test for CF means that a person has a mutation of the CF gene; this result is more than 99 percent accurate. A "negative" carrier test result is not as accurate. With more than 1,000 different mutations of the CF gene, there are some rare ones that the test does not identify. Thus, if your test is negative for a mutation of the CF gene, there is still a small chance you could be a carrier of one of the rare mutations. This chance depends on your race or ethnic group and the type of genetic carrier test you receive.

back to top

If I have one copy of the defective CF gene, can my children have CF?

Yes. If you have one copy of a CF gene mutation, your child may have CF. However, your child will only have CF if your partner also is a carrier of a CF gene mutation. If you are both carriers, each child you have together has a 25 percent chance of having CF. If one partner is a carrier and the other partner's test result is negative for a CF gene mutation (or if there is no information on whether or not he or she carries the defective gene), there is still a slight chance the child could have CF. Your doctor or a genetic counselor can tell you about your individual chances of having a child with CF.

back to top

How does CF "appear" when no one in my family has ever had the disease?

Since having one copy of the defective CF gene does not cause symptoms, this copy can be passed down to family members without any impact on their health. Unless they have a child with CF, most people who are carriers of the gene do not know it.

Once parents have a child diagnosed with CF, all of their children should be tested for the disease, whether they are showing symptoms or not. Other relatives also have a chance of being CF carriers and may wish to get a genetic carrier test for CF, or they may wish to be given the sweat test if they are showing symptoms of CF.

back to top
 
C

Cherylwithone

Guest
This is from the Cystic Fibrosis Foundation in the US.
I hope it helps


How does someone inherit a mutation of the CF gene?

People inherit genes from their parents. To have CF, a child must inherit one copy of a mutation of the CF gene from each parent. In other words, the child must have two copies of the defective gene to have CF. They could have two copies of one CF mutation, or have a copy of one CF mutation and a copy of another CF mutation.

A person who has only one copy of one mutation does not have CF and is considered a "carrier" of the CF gene. Both males and females can have the disease.

back to top

What does a positive genetic carrier test for CF mean?

A "positive" genetic carrier test for CF means that a person has a mutation of the CF gene; this result is more than 99 percent accurate. A "negative" carrier test result is not as accurate. With more than 1,000 different mutations of the CF gene, there are some rare ones that the test does not identify. Thus, if your test is negative for a mutation of the CF gene, there is still a small chance you could be a carrier of one of the rare mutations. This chance depends on your race or ethnic group and the type of genetic carrier test you receive.

back to top

If I have one copy of the defective CF gene, can my children have CF?

Yes. If you have one copy of a CF gene mutation, your child may have CF. However, your child will only have CF if your partner also is a carrier of a CF gene mutation. If you are both carriers, each child you have together has a 25 percent chance of having CF. If one partner is a carrier and the other partner's test result is negative for a CF gene mutation (or if there is no information on whether or not he or she carries the defective gene), there is still a slight chance the child could have CF. Your doctor or a genetic counselor can tell you about your individual chances of having a child with CF.

back to top

How does CF "appear" when no one in my family has ever had the disease?

Since having one copy of the defective CF gene does not cause symptoms, this copy can be passed down to family members without any impact on their health. Unless they have a child with CF, most people who are carriers of the gene do not know it.

Once parents have a child diagnosed with CF, all of their children should be tested for the disease, whether they are showing symptoms or not. Other relatives also have a chance of being CF carriers and may wish to get a genetic carrier test for CF, or they may wish to be given the sweat test if they are showing symptoms of CF.

back to top
 
C

Cherylwithone

Guest
This is from the Cystic Fibrosis Foundation in the US.
I hope it helps


How does someone inherit a mutation of the CF gene?

People inherit genes from their parents. To have CF, a child must inherit one copy of a mutation of the CF gene from each parent. In other words, the child must have two copies of the defective gene to have CF. They could have two copies of one CF mutation, or have a copy of one CF mutation and a copy of another CF mutation.

A person who has only one copy of one mutation does not have CF and is considered a "carrier" of the CF gene. Both males and females can have the disease.

back to top

What does a positive genetic carrier test for CF mean?

A "positive" genetic carrier test for CF means that a person has a mutation of the CF gene; this result is more than 99 percent accurate. A "negative" carrier test result is not as accurate. With more than 1,000 different mutations of the CF gene, there are some rare ones that the test does not identify. Thus, if your test is negative for a mutation of the CF gene, there is still a small chance you could be a carrier of one of the rare mutations. This chance depends on your race or ethnic group and the type of genetic carrier test you receive.

back to top

If I have one copy of the defective CF gene, can my children have CF?

Yes. If you have one copy of a CF gene mutation, your child may have CF. However, your child will only have CF if your partner also is a carrier of a CF gene mutation. If you are both carriers, each child you have together has a 25 percent chance of having CF. If one partner is a carrier and the other partner's test result is negative for a CF gene mutation (or if there is no information on whether or not he or she carries the defective gene), there is still a slight chance the child could have CF. Your doctor or a genetic counselor can tell you about your individual chances of having a child with CF.

back to top

How does CF "appear" when no one in my family has ever had the disease?

Since having one copy of the defective CF gene does not cause symptoms, this copy can be passed down to family members without any impact on their health. Unless they have a child with CF, most people who are carriers of the gene do not know it.

Once parents have a child diagnosed with CF, all of their children should be tested for the disease, whether they are showing symptoms or not. Other relatives also have a chance of being CF carriers and may wish to get a genetic carrier test for CF, or they may wish to be given the sweat test if they are showing symptoms of CF.

back to top
 
C

Cherylwithone

Guest
This is from the Cystic Fibrosis Foundation in the US.
<br />I hope it helps
<br />
<br />
<br />How does someone inherit a mutation of the CF gene?
<br />
<br />People inherit genes from their parents. To have CF, a child must inherit one copy of a mutation of the CF gene from each parent. In other words, the child must have two copies of the defective gene to have CF. They could have two copies of one CF mutation, or have a copy of one CF mutation and a copy of another CF mutation.
<br />
<br />A person who has only one copy of one mutation does not have CF and is considered a "carrier" of the CF gene. Both males and females can have the disease.
<br />
<br />back to top
<br />
<br />What does a positive genetic carrier test for CF mean?
<br />
<br />A "positive" genetic carrier test for CF means that a person has a mutation of the CF gene; this result is more than 99 percent accurate. A "negative" carrier test result is not as accurate. With more than 1,000 different mutations of the CF gene, there are some rare ones that the test does not identify. Thus, if your test is negative for a mutation of the CF gene, there is still a small chance you could be a carrier of one of the rare mutations. This chance depends on your race or ethnic group and the type of genetic carrier test you receive.
<br />
<br />back to top
<br />
<br />If I have one copy of the defective CF gene, can my children have CF?
<br />
<br />Yes. If you have one copy of a CF gene mutation, your child may have CF. However, your child will only have CF if your partner also is a carrier of a CF gene mutation. If you are both carriers, each child you have together has a 25 percent chance of having CF. If one partner is a carrier and the other partner's test result is negative for a CF gene mutation (or if there is no information on whether or not he or she carries the defective gene), there is still a slight chance the child could have CF. Your doctor or a genetic counselor can tell you about your individual chances of having a child with CF.
<br />
<br />back to top
<br />
<br />How does CF "appear" when no one in my family has ever had the disease?
<br />
<br />Since having one copy of the defective CF gene does not cause symptoms, this copy can be passed down to family members without any impact on their health. Unless they have a child with CF, most people who are carriers of the gene do not know it.
<br />
<br />Once parents have a child diagnosed with CF, all of their children should be tested for the disease, whether they are showing symptoms or not. Other relatives also have a chance of being CF carriers and may wish to get a genetic carrier test for CF, or they may wish to be given the sweat test if they are showing symptoms of CF.
<br />
<br />back to top
 
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