I have had some flare ups of belly distention, digestive issues, etc. in the past that I went to see my gastroenterologist for. She always was on the fence about diagnosing me with IBS. She always made sure that there was no infection of H. Pylori before concluding that as well. I've always had more prominent digestive involvement my whole life. My CF clinician suggested that my digestive system, as other CFers, have a sluggish digestive tract and sometimes things just don't move as quickly as they should and when that happens, it can feel much like IBS symptoms. We always would add some more enzymes to each meal, taking an acidophilus supplement, and the gastro gave me "Align" to help treat the immediate symptoms. Believe it or not, the Align did work! It really helped me. I also had some acid reflux so she gave me Protonix.