Colonized Pseudomonas

scrapper1264

New member
5 yo DS cultured for pseudomonas 2 wks ago after just being diagnosed with CF 2 wks before that. Ok, so I am trying to understand these pseudomonas and have done several searches here and am confused. How do you know if the pseudomonas have colonized? Colonized meaning worse right? Do colonized respond to tobi? At the time he cultured I asked his dr if this was the common one and he said yes. Then I just started reading about colonization and am therefore confused.

Thanks for any help!!
 

scrapper1264

New member
5 yo DS cultured for pseudomonas 2 wks ago after just being diagnosed with CF 2 wks before that. Ok, so I am trying to understand these pseudomonas and have done several searches here and am confused. How do you know if the pseudomonas have colonized? Colonized meaning worse right? Do colonized respond to tobi? At the time he cultured I asked his dr if this was the common one and he said yes. Then I just started reading about colonization and am therefore confused.

Thanks for any help!!
 

scrapper1264

New member
5 yo DS cultured for pseudomonas 2 wks ago after just being diagnosed with CF 2 wks before that. Ok, so I am trying to understand these pseudomonas and have done several searches here and am confused. How do you know if the pseudomonas have colonized? Colonized meaning worse right? Do colonized respond to tobi? At the time he cultured I asked his dr if this was the common one and he said yes. Then I just started reading about colonization and am therefore confused.

Thanks for any help!!
 

scrapper1264

New member
5 yo DS cultured for pseudomonas 2 wks ago after just being diagnosed with CF 2 wks before that. Ok, so I am trying to understand these pseudomonas and have done several searches here and am confused. How do you know if the pseudomonas have colonized? Colonized meaning worse right? Do colonized respond to tobi? At the time he cultured I asked his dr if this was the common one and he said yes. Then I just started reading about colonization and am therefore confused.

Thanks for any help!!
 

scrapper1264

New member
5 yo DS cultured for pseudomonas 2 wks ago after just being diagnosed with CF 2 wks before that. Ok, so I am trying to understand these pseudomonas and have done several searches here and am confused. How do you know if the pseudomonas have colonized? Colonized meaning worse right? Do colonized respond to tobi? At the time he cultured I asked his dr if this was the common one and he said yes. Then I just started reading about colonization and am therefore confused.

Thanks for any help!!
 

Alyssa

New member
The colonizing usually happens with the mucoid PA.

Generally speaking here's how it most often goes (someone please correct me if I'm off here) and I know there are exceptions to every rule....but by and large I believe this is accurate.

Patient starts with non mucoid PA (pseudomonas) Non-mucoid is easier to treat and get rid of. Often times if caught early and treated aggressively (oral antibiotics, Tobi and sometimes IV antibiotics) a patient can clear the PA within 1-3 months and it doesn't come back for a long while.

If the patient cannot clear it within a relatively short period of time, it stays around and after a period of something like say 6-18 months it mutates into mucoid PA. This is a little worse because the bacteria actually has a coating around itself that works as a barrier against antibiotics so it's harder to treat. Often times the best anyone can hope for it to knock down the number of bacteria but you can not longer count on eradicating it all. It's at this point when someone is considered to be "colonized with PA"

Does that help?

Hopefully your little guy can clear it out and be done with it -- my daughter cultured PA once when she was about 15 years old -- she is now 19 and has not cultured it again yet.
 

Alyssa

New member
The colonizing usually happens with the mucoid PA.

Generally speaking here's how it most often goes (someone please correct me if I'm off here) and I know there are exceptions to every rule....but by and large I believe this is accurate.

Patient starts with non mucoid PA (pseudomonas) Non-mucoid is easier to treat and get rid of. Often times if caught early and treated aggressively (oral antibiotics, Tobi and sometimes IV antibiotics) a patient can clear the PA within 1-3 months and it doesn't come back for a long while.

If the patient cannot clear it within a relatively short period of time, it stays around and after a period of something like say 6-18 months it mutates into mucoid PA. This is a little worse because the bacteria actually has a coating around itself that works as a barrier against antibiotics so it's harder to treat. Often times the best anyone can hope for it to knock down the number of bacteria but you can not longer count on eradicating it all. It's at this point when someone is considered to be "colonized with PA"

Does that help?

Hopefully your little guy can clear it out and be done with it -- my daughter cultured PA once when she was about 15 years old -- she is now 19 and has not cultured it again yet.
 

Alyssa

New member
The colonizing usually happens with the mucoid PA.

Generally speaking here's how it most often goes (someone please correct me if I'm off here) and I know there are exceptions to every rule....but by and large I believe this is accurate.

Patient starts with non mucoid PA (pseudomonas) Non-mucoid is easier to treat and get rid of. Often times if caught early and treated aggressively (oral antibiotics, Tobi and sometimes IV antibiotics) a patient can clear the PA within 1-3 months and it doesn't come back for a long while.

If the patient cannot clear it within a relatively short period of time, it stays around and after a period of something like say 6-18 months it mutates into mucoid PA. This is a little worse because the bacteria actually has a coating around itself that works as a barrier against antibiotics so it's harder to treat. Often times the best anyone can hope for it to knock down the number of bacteria but you can not longer count on eradicating it all. It's at this point when someone is considered to be "colonized with PA"

Does that help?

Hopefully your little guy can clear it out and be done with it -- my daughter cultured PA once when she was about 15 years old -- she is now 19 and has not cultured it again yet.
 

Alyssa

New member
The colonizing usually happens with the mucoid PA.

Generally speaking here's how it most often goes (someone please correct me if I'm off here) and I know there are exceptions to every rule....but by and large I believe this is accurate.

Patient starts with non mucoid PA (pseudomonas) Non-mucoid is easier to treat and get rid of. Often times if caught early and treated aggressively (oral antibiotics, Tobi and sometimes IV antibiotics) a patient can clear the PA within 1-3 months and it doesn't come back for a long while.

If the patient cannot clear it within a relatively short period of time, it stays around and after a period of something like say 6-18 months it mutates into mucoid PA. This is a little worse because the bacteria actually has a coating around itself that works as a barrier against antibiotics so it's harder to treat. Often times the best anyone can hope for it to knock down the number of bacteria but you can not longer count on eradicating it all. It's at this point when someone is considered to be "colonized with PA"

Does that help?

Hopefully your little guy can clear it out and be done with it -- my daughter cultured PA once when she was about 15 years old -- she is now 19 and has not cultured it again yet.
 

Alyssa

New member
The colonizing usually happens with the mucoid PA.

Generally speaking here's how it most often goes (someone please correct me if I'm off here) and I know there are exceptions to every rule....but by and large I believe this is accurate.

Patient starts with non mucoid PA (pseudomonas) Non-mucoid is easier to treat and get rid of. Often times if caught early and treated aggressively (oral antibiotics, Tobi and sometimes IV antibiotics) a patient can clear the PA within 1-3 months and it doesn't come back for a long while.

If the patient cannot clear it within a relatively short period of time, it stays around and after a period of something like say 6-18 months it mutates into mucoid PA. This is a little worse because the bacteria actually has a coating around itself that works as a barrier against antibiotics so it's harder to treat. Often times the best anyone can hope for it to knock down the number of bacteria but you can not longer count on eradicating it all. It's at this point when someone is considered to be "colonized with PA"

Does that help?

Hopefully your little guy can clear it out and be done with it -- my daughter cultured PA once when she was about 15 years old -- she is now 19 and has not cultured it again yet.
 

LouLou

New member
There's no definitive test to know if the pseudo. aero (PA) has colonized. Colonized means it's taken up permanent residence. I don't believe it has to be mucoid version of PA to colonize. I have had PA non-mucoid most of my life which means I am colonized. I showed up with mucoid PA in my early 20s. I now colonize that as well. If sputum cultures show a bug for more than 6 mo. continuously then most likely the patient is colonized. Treatment doesn't really change. Either way most patients are only treated for exacerbations. Although if it is suspected that the patient is not colonized. He/she might be treated with some abx to try to knock it out even if he/she isn't outwardly sick. I hope this helps.
 

LouLou

New member
There's no definitive test to know if the pseudo. aero (PA) has colonized. Colonized means it's taken up permanent residence. I don't believe it has to be mucoid version of PA to colonize. I have had PA non-mucoid most of my life which means I am colonized. I showed up with mucoid PA in my early 20s. I now colonize that as well. If sputum cultures show a bug for more than 6 mo. continuously then most likely the patient is colonized. Treatment doesn't really change. Either way most patients are only treated for exacerbations. Although if it is suspected that the patient is not colonized. He/she might be treated with some abx to try to knock it out even if he/she isn't outwardly sick. I hope this helps.
 

LouLou

New member
There's no definitive test to know if the pseudo. aero (PA) has colonized. Colonized means it's taken up permanent residence. I don't believe it has to be mucoid version of PA to colonize. I have had PA non-mucoid most of my life which means I am colonized. I showed up with mucoid PA in my early 20s. I now colonize that as well. If sputum cultures show a bug for more than 6 mo. continuously then most likely the patient is colonized. Treatment doesn't really change. Either way most patients are only treated for exacerbations. Although if it is suspected that the patient is not colonized. He/she might be treated with some abx to try to knock it out even if he/she isn't outwardly sick. I hope this helps.
 

LouLou

New member
There's no definitive test to know if the pseudo. aero (PA) has colonized. Colonized means it's taken up permanent residence. I don't believe it has to be mucoid version of PA to colonize. I have had PA non-mucoid most of my life which means I am colonized. I showed up with mucoid PA in my early 20s. I now colonize that as well. If sputum cultures show a bug for more than 6 mo. continuously then most likely the patient is colonized. Treatment doesn't really change. Either way most patients are only treated for exacerbations. Although if it is suspected that the patient is not colonized. He/she might be treated with some abx to try to knock it out even if he/she isn't outwardly sick. I hope this helps.
 

LouLou

New member
There's no definitive test to know if the pseudo. aero (PA) has colonized. Colonized means it's taken up permanent residence. I don't believe it has to be mucoid version of PA to colonize. I have had PA non-mucoid most of my life which means I am colonized. I showed up with mucoid PA in my early 20s. I now colonize that as well. If sputum cultures show a bug for more than 6 mo. continuously then most likely the patient is colonized. Treatment doesn't really change. Either way most patients are only treated for exacerbations. Although if it is suspected that the patient is not colonized. He/she might be treated with some abx to try to knock it out even if he/she isn't outwardly sick. I hope this helps.
 
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