False positives are rare, but do happen and is normally caused by the nurse or tech doing the test not doing it correctly. There are some medical reasons you can get a positive sweat test result, yet not have CF, but many of them are fairly uncommon diseases/syndromes and their symptoms aren't consistent with CF. Here is a list of the diseases and syndromes that I found online a few years ago:"Adrenal insufficiency, anorexia nervosa, atopic dermatitis, autonomic dysfunction, <b>coeliac disease</b>, ectodermal dysplasia, familial cholestasis (Byler's disease), fucosidosis, G6PD deficiency, glycogen storage disease type 1, hypogammaglobulinemia, hypoparathyroidism, hypothyroidism, Klinefelter's syndrome, <b>malnutrition</b>, mucopolysaccharidosis type 1, nephrogenic diabetes insipidus, nephrosis, pseudohypoaldosteronism, psychosocial problems (Rosenstein & Cutting, 1998, Duddy et al, 1987)". I highlighted the two more common reasons.Have you had the sweat tests repeated? Are they experiencing symptoms of CF?My son is in the same boat, he had numerous high sweat tests (very high), yet genetics did not show anything. He was diagnosed based on the sweat test and symptoms.