I'm DDF508 and according to my doctors I'm PI. When I was younger I had a lot of trouble gaining weight. Now for the past 4 or 5 years, I haven't had any trouble at all. I hardly ever take my enzymes, maybe 3 or 4 times a month at the most. But I weight 145 lbs and I'm 5'4", so I'm a little chuncky. So yea I think it can change over time.