Okay, it appears to me by looking at other studies that 20 mL is about 1%. So, it appears that those on Denufosol had an FEV1 increase of about 6% after 48 weeks. The only thing that worries me is that if I get the placebo, since you aren't allowed to be on hypertonic that my lung function may decrease in the first year without hypertonic or Denufosol. The second year I would get to be on Denufosol for sure though...