Yes, my daughters both had terrible bottoms. It was heartbreaking how raw they would look, no matter what I did. I do remember getting a prescription to help. And whenever I could, I would take the diaper off and just let them lay/sit and play on something absorbent, like a changing/diaper pad, just in case they had an accident. It seemed to help their bottoms dry out a little.
It's been a while since mine were that little, but it was really an issue for me and I know they had to be miserable.