I went with the medicare advantage plans. you have to watch those though, you might need to switch plans like i did because the plan i had dropped my CF clinic hospital's pharmacy from their plan. There are multiple copay assistance options. do a search for copay assistance programs. i was told by one, they wouldn't cover me if I had more than one copay assistance. turns out, that's up to the program because frequently costs are greater than what one program covers (some up to $12,000 some to $15,000 for CF) what mine do is certain drugs are paid by one, and the other covers copay on others. I can't tell you what I actually pay for trikafta... Expect that in the first month, which is always your copay month, you'll go through the donut hole and land in stage 4 by February... according to my jan statement, trikafta was $24878 and my copay was 0. but that's because they charged my zenpep first which out of pocket was over $2000 (which copay relief covered.)