I've had more than 105 tune ups for CF exacerbations in my lifetime and EVERYONE has involved venous access. Whether this be by peripheral IV, PICC, Midline, Port, femoral access or other, it is always done with the intention of gaining access to the vasculature for the purpose of providing antibiotic therapy. Put another way, I've never NOT have an IV during a tune up, as that is the time I am at my worse and oral abx just don't cut it...so pull out the Big Guns and load me up with IV abx.