Emily has an 18fr tube. She uses a predigested formula high in mct fat- both of which are much easier for those with cf to digest (Peptamen Jr 1.5) and we were told she likely needs fewer enzymes with this formula than she would need for real food with the same amount of fat and calories.
And speaking as a mom, not as a professional... The whole 'enzymes need to be in an acidic food to work' thing... realistically speaking, parents of babies are told this and much is made of it, but real life and practicality is going to take over at some point. Kids and adults take enzymes with WHATEVER they eat, and they work just fine. If Emily is having ice cream for her bedtime snack, having them in a spoonful of applesauce first vs. taking them with water will not make a bit of difference, it will all get mixed up in her stomach long before it ever reaches the intestine- it's not like those enzymes stay buried in that applesauce until they make it to the duodenum, and the gelatin capsule is gone within a few minutes as well- it's the beads that are enteric coated, not the capsule that holds them.