Successful decolonization of methicillin-resistant Staphylococcus aureus in paediatric patients with cystic fibrosis (CF) using a three-step protocol.
Macfarlane M, Leavy A, McCaughan J, Fair R, Reid AJ.
Northern Ireland Paediatric CF Centre, Royal Belfast Hospital for Sick Children, Royal Group of Hospitals, Belfast, Northern Ireland, UK.
Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as a bacterial pathogen in patients with cystic fibrosis (CF) although its clinical effects can be variable. The aim of this study was to evaluate the efficacy of a three-step decolonization protocol for MRSA (Belfast CF MRSA decolonization protocol). Of the 17 paediatric patients treated during the five years of the study, eight (47%) were successfully decolonized following one five-day course of oral rifampicin and fusidic acid. The success rate increased to 12 (71%) patients after a second five-day oral treatment course in the 11 patients who remained culture positive at the end of the first treatment cycle. In a further four patients, clearance was achieved with a course of intravenous teicoplanin, increasing the decolonization rate to 16 of 17 patients (94%). <b>These results compare favourably with other published studies and show that MRSA decolonization can be successful in a high proportion of paediatric CF patients</b>
Macfarlane M, Leavy A, McCaughan J, Fair R, Reid AJ.
Northern Ireland Paediatric CF Centre, Royal Belfast Hospital for Sick Children, Royal Group of Hospitals, Belfast, Northern Ireland, UK.
Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as a bacterial pathogen in patients with cystic fibrosis (CF) although its clinical effects can be variable. The aim of this study was to evaluate the efficacy of a three-step decolonization protocol for MRSA (Belfast CF MRSA decolonization protocol). Of the 17 paediatric patients treated during the five years of the study, eight (47%) were successfully decolonized following one five-day course of oral rifampicin and fusidic acid. The success rate increased to 12 (71%) patients after a second five-day oral treatment course in the 11 patients who remained culture positive at the end of the first treatment cycle. In a further four patients, clearance was achieved with a course of intravenous teicoplanin, increasing the decolonization rate to 16 of 17 patients (94%). <b>These results compare favourably with other published studies and show that MRSA decolonization can be successful in a high proportion of paediatric CF patients</b>