F508 Delta

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laciandgabesmumma

New member
I just found out that my daughter, Laci, who just turned 6 has the F508 Delta mutation. We've always known that she has cystic fibrosis but I just found out which mutation she has. Is there anything I should know about this? I can google all I want but I would rather get the opinions and knowledge of you guys <img src="i/expressions/face-icon-small-smile.gif" border="0"> <br>Thank you!<br>
 
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laciandgabesmumma

New member
I just found out that my daughter, Laci, who just turned 6 has the F508 Delta mutation. We've always known that she has cystic fibrosis but I just found out which mutation she has. Is there anything I should know about this? I can google all I want but I would rather get the opinions and knowledge of you guys <img src="i/expressions/face-icon-small-smile.gif" border="0"> <br>Thank you!<br>
 
L

laciandgabesmumma

New member
I just found out that my daughter, Laci, who just turned 6 has the F508 Delta mutation. We've always known that she has cystic fibrosis but I just found out which mutation she has. Is there anything I should know about this? I can google all I want but I would rather get the opinions and knowledge of you guys <img src="i/expressions/face-icon-small-smile.gif" border="0"> <br>Thank you!<br>
 
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Ratatosk

Administrator
Staff member
DS has that mutation and tends to have more digestive issues, which is how we found out he had CF as he was born with a bowel obstruction caused by meconium illeus. So needs enzymes. Seems to be saltier than most -- sweats out a lot of salt, tends to eat a lot of salt and salty snacks. Does have some sinus issues --- mainly his nose has never ever run due to the extra thick sticky mucus up there.

With mutations, the same mutation can effect people differently. Siblings are affected differently. I remember one person on this site with this mutation who wasn't diagnosed until she was 7. A friend of mine's daughter was diagnosed at 18 months because she had frequent upper respiratory infections and the doctor ran a sweat test to "rule out cf".
 
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Ratatosk

Administrator
Staff member
DS has that mutation and tends to have more digestive issues, which is how we found out he had CF as he was born with a bowel obstruction caused by meconium illeus. So needs enzymes. Seems to be saltier than most -- sweats out a lot of salt, tends to eat a lot of salt and salty snacks. Does have some sinus issues --- mainly his nose has never ever run due to the extra thick sticky mucus up there.

With mutations, the same mutation can effect people differently. Siblings are affected differently. I remember one person on this site with this mutation who wasn't diagnosed until she was 7. A friend of mine's daughter was diagnosed at 18 months because she had frequent upper respiratory infections and the doctor ran a sweat test to "rule out cf".
 
R

Ratatosk

Administrator
Staff member
DS has that mutation and tends to have more digestive issues, which is how we found out he had CF as he was born with a bowel obstruction caused by meconium illeus. So needs enzymes. Seems to be saltier than most -- sweats out a lot of salt, tends to eat a lot of salt and salty snacks. Does have some sinus issues --- mainly his nose has never ever run due to the extra thick sticky mucus up there.
<br />
<br />With mutations, the same mutation can effect people differently. Siblings are affected differently. I remember one person on this site with this mutation who wasn't diagnosed until she was 7. A friend of mine's daughter was diagnosed at 18 months because she had frequent upper respiratory infections and the doctor ran a sweat test to "rule out cf".
 
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CJPsMom

New member
My little guy is a homozygous delta F508. So far, we've had lots of digestive problems. The only time he really had any respiratory issues is when he had a cold, but I don't know how different his reaction was than what would have happened if he didn't have CF.

He's only 7 months old, so I don't know that our experience helps much!
 
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CJPsMom

New member
My little guy is a homozygous delta F508. So far, we've had lots of digestive problems. The only time he really had any respiratory issues is when he had a cold, but I don't know how different his reaction was than what would have happened if he didn't have CF.

He's only 7 months old, so I don't know that our experience helps much!
 
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CJPsMom

New member
My little guy is a homozygous delta F508. So far, we've had lots of digestive problems. The only time he really had any respiratory issues is when he had a cold, but I don't know how different his reaction was than what would have happened if he didn't have CF.
<br />
<br />He's only 7 months old, so I don't know that our experience helps much!
 
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laciandgabesmumma

New member
well I definitely appreciate both of you taking the time to write back to me, so thank you. <img src="i/expressions/face-icon-small-smile.gif" border="0"> I just get nervous googling anything on CF because it seems like everybody has something different to say about it and sometimes it can get discouraging.
 
L

laciandgabesmumma

New member
well I definitely appreciate both of you taking the time to write back to me, so thank you. <img src="i/expressions/face-icon-small-smile.gif" border="0"> I just get nervous googling anything on CF because it seems like everybody has something different to say about it and sometimes it can get discouraging.
 
L

laciandgabesmumma

New member
well I definitely appreciate both of you taking the time to write back to me, so thank you. <img src="i/expressions/face-icon-small-smile.gif" border="0"> I just get nervous googling anything on CF because it seems like everybody has something different to say about it and sometimes it can get discouraging.
 
2

2005CFmom

Super Moderator
My daughter is also homozygous delta F508 and she was diagnosed at 8 years old. She had a cough that would not go away and had stopped gaining weight.

The DeltaF508 mutation is the most common mutation. It normally produces "classical" CF symptoms effecting the lungs, digestive tract, reproductive systems. People with this mutation vary widely as to how severe and how quickly disease progresses. Since it does vary so widely, it really is not a good predictor of how your daughters disease will progress. Just that at some point (if it hasn't already) it will effect the lungs, pancreas, etc....
 
2

2005CFmom

Super Moderator
My daughter is also homozygous delta F508 and she was diagnosed at 8 years old. She had a cough that would not go away and had stopped gaining weight.

The DeltaF508 mutation is the most common mutation. It normally produces "classical" CF symptoms effecting the lungs, digestive tract, reproductive systems. People with this mutation vary widely as to how severe and how quickly disease progresses. Since it does vary so widely, it really is not a good predictor of how your daughters disease will progress. Just that at some point (if it hasn't already) it will effect the lungs, pancreas, etc....
 
2

2005CFmom

Super Moderator
My daughter is also homozygous delta F508 and she was diagnosed at 8 years old. She had a cough that would not go away and had stopped gaining weight.
<br />
<br />The DeltaF508 mutation is the most common mutation. It normally produces "classical" CF symptoms effecting the lungs, digestive tract, reproductive systems. People with this mutation vary widely as to how severe and how quickly disease progresses. Since it does vary so widely, it really is not a good predictor of how your daughters disease will progress. Just that at some point (if it hasn't already) it will effect the lungs, pancreas, etc....
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petnurse

New member
It really can vary. You may hear from people that it is the worst. This is because it is the most common, not because it is the worst. It is associated with digestive issues, but that can vary too. For example, my son is DDF508 and borderline pancreatic sufficient. I would not worry too much with the mutations until the medications are gene specific. :)
 
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petnurse

New member
It really can vary. You may hear from people that it is the worst. This is because it is the most common, not because it is the worst. It is associated with digestive issues, but that can vary too. For example, my son is DDF508 and borderline pancreatic sufficient. I would not worry too much with the mutations until the medications are gene specific. :)
 
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petnurse

New member
It really can vary. You may hear from people that it is the worst. This is because it is the most common, not because it is the worst. It is associated with digestive issues, but that can vary too. For example, my son is DDF508 and borderline pancreatic sufficient. I would not worry too much with the mutations until the medications are gene specific. :)
 
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MommaKas

Guest
My daughter is homozygous delta F508. She wasn't diagnosed until last year just a few months shy of her 11th birthday. She has had symptoms since birth and they started out as more GI related, but by the time she was diagnosed her PFT's we're in the 40's. They went back up after a tune up, but have slowly and steadily been dropping again. I believe it does effect everyone differently becaose other genes can compensate in certain areas. Bottom line is the sooner treatment starts the better no matter what mutation is causing the cf
.
 
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MommaKas

Guest
My daughter is homozygous delta F508. She wasn't diagnosed until last year just a few months shy of her 11th birthday. She has had symptoms since birth and they started out as more GI related, but by the time she was diagnosed her PFT's we're in the 40's. They went back up after a tune up, but have slowly and steadily been dropping again. I believe it does effect everyone differently becaose other genes can compensate in certain areas. Bottom line is the sooner treatment starts the better no matter what mutation is causing the cf
.
 
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