I dont know about the whole face being puffy, but sometime in my early 20's i started getting puffy under the eyes. This stayed with me, and since i have chronic sinusitis, i have not really found anything that gets rid of it. Some days worse than others. It is possible that what you are experiencing is related to your menstrual cycle. We tend to retain water right before the period begins. Is this about when you are noticing the puffiness? It's always possible it could be a reaction to a medication, or by allergies. Next time when you notice it, think about what is going on at the time.... Are you on a different medicine, period coming, feeling crappy, headaches, Take note of what is going on along with it and eventually you may get your answer. I would also ask the doctor about it. It's good to make them aware of changes , especially ones that concern you. Good luck ~ Diane