Gene Responsible for Sputum Production Found

[JazzysMom]

The gene responsible for sputum production commonly reported in many respiratory diseases but poorly treated with available medication has been found.

The reason contributing to excessive production of thick mucus and sputum, commonly reported in those with asthma and cystic fibrosis, had long been unclear.

Many believed the condition was the allergic response to airway inflammation produced by inflammation mucus cells, known as goblet cells.

According to a study published in the Journal of Clinical Investigation, a transcription factor, SPDEF, is the key gene that regulates a chain of genes - in particular FOXA3, AGR2 and mucins -- involved in mucous production.

Switching off the gene, therefore, can stop inflammation and mucus production process.

The study also showed that goblet cells change into cells called Clara cells during an inflammatory process, adding that the new cells are responsible for excessive mucus production.

"At present there are only a few treatments available and they are often not very effective," scientists said, adding that their findings will pave the way for the development of effective treatments in the near future.



<a target=_blank class=ftalternatingbarlinklarge href="http://www.presstv.ir/detail.aspx?id=106366&sectionid=3510210
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[JazzysMom]

The gene responsible for sputum production commonly reported in many respiratory diseases but poorly treated with available medication has been found.

The reason contributing to excessive production of thick mucus and sputum, commonly reported in those with asthma and cystic fibrosis, had long been unclear.

Many believed the condition was the allergic response to airway inflammation produced by inflammation mucus cells, known as goblet cells.

According to a study published in the Journal of Clinical Investigation, a transcription factor, SPDEF, is the key gene that regulates a chain of genes - in particular FOXA3, AGR2 and mucins -- involved in mucous production.

Switching off the gene, therefore, can stop inflammation and mucus production process.

The study also showed that goblet cells change into cells called Clara cells during an inflammatory process, adding that the new cells are responsible for excessive mucus production.

"At present there are only a few treatments available and they are often not very effective," scientists said, adding that their findings will pave the way for the development of effective treatments in the near future.



<a target=_blank class=ftalternatingbarlinklarge href="http://www.presstv.ir/detail.aspx?id=106366&sectionid=3510210
">http://www.presstv.ir/detail.a...366&sectionid=3510210
</a>

 

[JazzysMom]

The gene responsible for sputum production commonly reported in many respiratory diseases but poorly treated with available medication has been found.

The reason contributing to excessive production of thick mucus and sputum, commonly reported in those with asthma and cystic fibrosis, had long been unclear.

Many believed the condition was the allergic response to airway inflammation produced by inflammation mucus cells, known as goblet cells.

According to a study published in the Journal of Clinical Investigation, a transcription factor, SPDEF, is the key gene that regulates a chain of genes - in particular FOXA3, AGR2 and mucins -- involved in mucous production.

Switching off the gene, therefore, can stop inflammation and mucus production process.

The study also showed that goblet cells change into cells called Clara cells during an inflammatory process, adding that the new cells are responsible for excessive mucus production.

"At present there are only a few treatments available and they are often not very effective," scientists said, adding that their findings will pave the way for the development of effective treatments in the near future.



<a target=_blank class=ftalternatingbarlinklarge href="http://www.presstv.ir/detail.aspx?id=106366&sectionid=3510210
">http://www.presstv.ir/detail.a...366&sectionid=3510210
</a>

 

[JazzysMom]

The gene responsible for sputum production commonly reported in many respiratory diseases but poorly treated with available medication has been found.

The reason contributing to excessive production of thick mucus and sputum, commonly reported in those with asthma and cystic fibrosis, had long been unclear.

Many believed the condition was the allergic response to airway inflammation produced by inflammation mucus cells, known as goblet cells.

According to a study published in the Journal of Clinical Investigation, a transcription factor, SPDEF, is the key gene that regulates a chain of genes - in particular FOXA3, AGR2 and mucins -- involved in mucous production.

Switching off the gene, therefore, can stop inflammation and mucus production process.

The study also showed that goblet cells change into cells called Clara cells during an inflammatory process, adding that the new cells are responsible for excessive mucus production.

"At present there are only a few treatments available and they are often not very effective," scientists said, adding that their findings will pave the way for the development of effective treatments in the near future.



<a target=_blank class=ftalternatingbarlinklarge href="http://www.presstv.ir/detail.aspx?id=106366&sectionid=3510210
">http://www.presstv.ir/detail.a...366&sectionid=3510210
</a>

 

[JazzysMom]

The gene responsible for sputum production commonly reported in many respiratory diseases but poorly treated with available medication has been found.
<br />
<br />The reason contributing to excessive production of thick mucus and sputum, commonly reported in those with asthma and cystic fibrosis, had long been unclear.
<br />
<br />Many believed the condition was the allergic response to airway inflammation produced by inflammation mucus cells, known as goblet cells.
<br />
<br />According to a study published in the Journal of Clinical Investigation, a transcription factor, SPDEF, is the key gene that regulates a chain of genes - in particular FOXA3, AGR2 and mucins -- involved in mucous production.
<br />
<br />Switching off the gene, therefore, can stop inflammation and mucus production process.
<br />
<br />The study also showed that goblet cells change into cells called Clara cells during an inflammatory process, adding that the new cells are responsible for excessive mucus production.
<br />
<br />"At present there are only a few treatments available and they are often not very effective," scientists said, adding that their findings will pave the way for the development of effective treatments in the near future.
<br />
<br />
<br />
<br /><a target=_blank class=ftalternatingbarlinklarge href="http://www.presstv.ir/detail.aspx?id=106366&sectionid=3510210
">http://www.presstv.ir/detail.a...366&sectionid=3510210
</a><br />

 

[Melissa75]

Interesting!

My mucus gene must be switched on high, since I have been making too much mucus since birth, but have a sweat test of 11, was negative for the 90 mutation panel, and don't culture typical CF bacteria.

Despite getting allergy shots for >6 months, and the usual meds, something about September makes my sinuses just churn out post-nasal drip.

___
Melissa, 34, bronchiectasis (noCF)

 

[Melissa75]

Interesting!

My mucus gene must be switched on high, since I have been making too much mucus since birth, but have a sweat test of 11, was negative for the 90 mutation panel, and don't culture typical CF bacteria.

Despite getting allergy shots for >6 months, and the usual meds, something about September makes my sinuses just churn out post-nasal drip.

___
Melissa, 34, bronchiectasis (noCF)

 

[Melissa75]

Interesting!

My mucus gene must be switched on high, since I have been making too much mucus since birth, but have a sweat test of 11, was negative for the 90 mutation panel, and don't culture typical CF bacteria.

Despite getting allergy shots for >6 months, and the usual meds, something about September makes my sinuses just churn out post-nasal drip.

___
Melissa, 34, bronchiectasis (noCF)

 

[Melissa75]

Interesting!

My mucus gene must be switched on high, since I have been making too much mucus since birth, but have a sweat test of 11, was negative for the 90 mutation panel, and don't culture typical CF bacteria.

Despite getting allergy shots for >6 months, and the usual meds, something about September makes my sinuses just churn out post-nasal drip.

___
Melissa, 34, bronchiectasis (noCF)

 

[Melissa75]

Interesting!
<br />
<br />My mucus gene must be switched on high, since I have been making too much mucus since birth, but have a sweat test of 11, was negative for the 90 mutation panel, and don't culture typical CF bacteria.
<br />
<br />Despite getting allergy shots for >6 months, and the usual meds, something about September makes my sinuses just churn out post-nasal drip.
<br />
<br />___
<br />Melissa, 34, bronchiectasis (noCF)