Glutathione

N

NoExcuses

New member
NAC can be inhaled... it's called Mucomyst. This is Dr. Warwick's preferable way of obtaining NAC. I will also point you to my blog if you haven't read it where Warwick speaks about NAC, GSH and Mucomyst.

NAC can be taken orally as well. I bought mine at Whole Foods. The problem with pill forms of any supplement is that they're not regulated by the FDA. So the pill that you buy of NAC may or may not contain what the bottle says it contains. This goes for any supplement, including GSH.

So you need to make sure you buy your supplements from a reputable place. I went down to Whole Foods down the street and bought 60 600mg pills of NAC and I pop one a day.

I haven't been able to get an apt with my Pulmonologist since I returned from visited Warwick, so I'm not on Mucomyst yet. I haven't upped my NAC levels to 600mg BID because I want to make sure I"m not experiencing any side effects of taking NAC (I will need blood work for that). There's nothing like fixing one problem and having another pop up. I'm not diabetic, but apparently NAC can have an insulin-blocking effect, so that's something else to look out for too.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.formyhealth.com/nac_article.htm
">http://www.formyhealth.com/nac_article.htm
</a>
This site re-iterates what Warwick states. The site says "NAC is a much better source of glutathione than taking glutathione itself, because less than half of supplemental glutathione is absorbed from the digestive system. This greater efficiency is important since cellular glutathione levels tend to drop 30% to 35% with age."
 
N

NoExcuses

New member
NAC can be inhaled... it's called Mucomyst. This is Dr. Warwick's preferable way of obtaining NAC. I will also point you to my blog if you haven't read it where Warwick speaks about NAC, GSH and Mucomyst.

NAC can be taken orally as well. I bought mine at Whole Foods. The problem with pill forms of any supplement is that they're not regulated by the FDA. So the pill that you buy of NAC may or may not contain what the bottle says it contains. This goes for any supplement, including GSH.

So you need to make sure you buy your supplements from a reputable place. I went down to Whole Foods down the street and bought 60 600mg pills of NAC and I pop one a day.

I haven't been able to get an apt with my Pulmonologist since I returned from visited Warwick, so I'm not on Mucomyst yet. I haven't upped my NAC levels to 600mg BID because I want to make sure I"m not experiencing any side effects of taking NAC (I will need blood work for that). There's nothing like fixing one problem and having another pop up. I'm not diabetic, but apparently NAC can have an insulin-blocking effect, so that's something else to look out for too.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.formyhealth.com/nac_article.htm
">http://www.formyhealth.com/nac_article.htm
</a>
This site re-iterates what Warwick states. The site says "NAC is a much better source of glutathione than taking glutathione itself, because less than half of supplemental glutathione is absorbed from the digestive system. This greater efficiency is important since cellular glutathione levels tend to drop 30% to 35% with age."
 
N

NoExcuses

New member
<a target=_blank class=ftalternatingbarlinklarge href="http://www.vitacost.com/science/hn/Supp/N_Acetyl_Cysteine.htm
">http://www.vitacost.com/scienc...N_Acetyl_Cysteine.htm
</a>
this looks like a good site as well.

"NAC may increase urinary zinc excretion.16 Therefore, supplemental zinc and copper should be added when supplementing with NAC for extended periods."

"Certain medicines interact with N-Acetyl Cysteine: Some interactions may increase the need for N-Acetyl Cysteine (), other interactions may be negative () and indicate N-Acetyl Cysteine should not be taken without first speaking with your physician or pharmacist, others may require further explanation (). Refer to the individual drug article for specific details about an interaction.

Note: the following list only includes the generic or class name of a medicine - to find a specific brand name, use the Safetychecker index.

Acetaminophen
AZT
Chemotherapy
Cisplatin
Clozapine
Cyclophosphamide
Docetaxel
Doxorubicin
Fluorouracil
Flurbiprofen
Gentamicin
Interferon
Isosorbide Dinitrate
Isosorbide Mononitrate
Metoclopramide
Nitroglycerin
Oral Corticosteroids
Paclitaxel "
 
N

NoExcuses

New member
<a target=_blank class=ftalternatingbarlinklarge href="http://www.vitacost.com/science/hn/Supp/N_Acetyl_Cysteine.htm
">http://www.vitacost.com/scienc...N_Acetyl_Cysteine.htm
</a>
this looks like a good site as well.

"NAC may increase urinary zinc excretion.16 Therefore, supplemental zinc and copper should be added when supplementing with NAC for extended periods."

"Certain medicines interact with N-Acetyl Cysteine: Some interactions may increase the need for N-Acetyl Cysteine (), other interactions may be negative () and indicate N-Acetyl Cysteine should not be taken without first speaking with your physician or pharmacist, others may require further explanation (). Refer to the individual drug article for specific details about an interaction.

Note: the following list only includes the generic or class name of a medicine - to find a specific brand name, use the Safetychecker index.

Acetaminophen
AZT
Chemotherapy
Cisplatin
Clozapine
Cyclophosphamide
Docetaxel
Doxorubicin
Fluorouracil
Flurbiprofen
Gentamicin
Interferon
Isosorbide Dinitrate
Isosorbide Mononitrate
Metoclopramide
Nitroglycerin
Oral Corticosteroids
Paclitaxel "
 
N

NoExcuses

New member
<a target=_blank class=ftalternatingbarlinklarge href="http://www.vitacost.com/science/hn/Supp/N_Acetyl_Cysteine.htm
">http://www.vitacost.com/scienc...N_Acetyl_Cysteine.htm
</a>
this looks like a good site as well.

"NAC may increase urinary zinc excretion.16 Therefore, supplemental zinc and copper should be added when supplementing with NAC for extended periods."

"Certain medicines interact with N-Acetyl Cysteine: Some interactions may increase the need for N-Acetyl Cysteine (), other interactions may be negative () and indicate N-Acetyl Cysteine should not be taken without first speaking with your physician or pharmacist, others may require further explanation (). Refer to the individual drug article for specific details about an interaction.

Note: the following list only includes the generic or class name of a medicine - to find a specific brand name, use the Safetychecker index.

Acetaminophen
AZT
Chemotherapy
Cisplatin
Clozapine
Cyclophosphamide
Docetaxel
Doxorubicin
Fluorouracil
Flurbiprofen
Gentamicin
Interferon
Isosorbide Dinitrate
Isosorbide Mononitrate
Metoclopramide
Nitroglycerin
Oral Corticosteroids
Paclitaxel "
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>

The site says "NAC is a much better source of glutathione than taking glutathione itself, because less than half of supplemental glutathione is absorbed from the digestive system. This greater efficiency is important since cellular glutathione levels tend to drop 30% to 35% with age."</end quote></div>

True, but at the same time, GSH cannot reach the extracellular environment where it is needed, because CFTR is also partly responsible for GSH transport. So while you are getting more GSH produced inside the cells, it's not doing much for the outside, where a lot of oxidants are being produced...

Perhaps you could take a dose of NAC, but also supplement that with some GSH. There are other forms of GSH out there as well, including suppositories, inhalable form and liposomal gsh (encapsulated gsh...readily absorbable in the gut). Hell you could even make your own nasal spray hehe.

One more thing...denatured whey protein contains a lot of Cystine, which is the oxidized form of cysteine, and is a better way to get cysteine. It is virtually non toxic(as opposed to cysteine) and is more readily available then the cysteine...

<a target=_blank class=ftalternatingbarlinklarge href="http://en.wikipedia.org/wiki/Cystine
">http://en.wikipedia.org/wiki/Cystine
</a>
"The free amino acid cysteine does not represent an ideal delivery system to the cell. It is potentially toxic and is easily catabolized spontaneously in the gastrointestinal tract and in the blood plasma. However, cysteine which is absorbed during digestion as cystine (two cysteine molecules linked by a disulfide bond) is more stable than the free amino acid cysteine. The disulfide bond is pepsin and trypsin-resistant (two important digestive enzymes in the stomach), but may be split by heat, low pH, and mechanical stress. Cystine travels safely through the GI tract and blood plasma and is promptly reduced to the two cysteine molecules upon cell entry."

A proven good source is something called immunocal...but it is expensive as hell.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.immunocal.com/
">http://www.immunocal.com/
</a>
however, here is a much cheaper source. I am sure there are others out there...

<a target=_blank class=ftalternatingbarlinklarge href="http://www.lef.org/newshop/items/item00509.html
">http://www.lef.org/newshop/items/item00509.html
</a>
Hope that helps...

Kiel
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>

The site says "NAC is a much better source of glutathione than taking glutathione itself, because less than half of supplemental glutathione is absorbed from the digestive system. This greater efficiency is important since cellular glutathione levels tend to drop 30% to 35% with age."</end quote></div>

True, but at the same time, GSH cannot reach the extracellular environment where it is needed, because CFTR is also partly responsible for GSH transport. So while you are getting more GSH produced inside the cells, it's not doing much for the outside, where a lot of oxidants are being produced...

Perhaps you could take a dose of NAC, but also supplement that with some GSH. There are other forms of GSH out there as well, including suppositories, inhalable form and liposomal gsh (encapsulated gsh...readily absorbable in the gut). Hell you could even make your own nasal spray hehe.

One more thing...denatured whey protein contains a lot of Cystine, which is the oxidized form of cysteine, and is a better way to get cysteine. It is virtually non toxic(as opposed to cysteine) and is more readily available then the cysteine...

<a target=_blank class=ftalternatingbarlinklarge href="http://en.wikipedia.org/wiki/Cystine
">http://en.wikipedia.org/wiki/Cystine
</a>
"The free amino acid cysteine does not represent an ideal delivery system to the cell. It is potentially toxic and is easily catabolized spontaneously in the gastrointestinal tract and in the blood plasma. However, cysteine which is absorbed during digestion as cystine (two cysteine molecules linked by a disulfide bond) is more stable than the free amino acid cysteine. The disulfide bond is pepsin and trypsin-resistant (two important digestive enzymes in the stomach), but may be split by heat, low pH, and mechanical stress. Cystine travels safely through the GI tract and blood plasma and is promptly reduced to the two cysteine molecules upon cell entry."

A proven good source is something called immunocal...but it is expensive as hell.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.immunocal.com/
">http://www.immunocal.com/
</a>
however, here is a much cheaper source. I am sure there are others out there...

<a target=_blank class=ftalternatingbarlinklarge href="http://www.lef.org/newshop/items/item00509.html
">http://www.lef.org/newshop/items/item00509.html
</a>
Hope that helps...

Kiel
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>

The site says "NAC is a much better source of glutathione than taking glutathione itself, because less than half of supplemental glutathione is absorbed from the digestive system. This greater efficiency is important since cellular glutathione levels tend to drop 30% to 35% with age."</end quote></div>

True, but at the same time, GSH cannot reach the extracellular environment where it is needed, because CFTR is also partly responsible for GSH transport. So while you are getting more GSH produced inside the cells, it's not doing much for the outside, where a lot of oxidants are being produced...

Perhaps you could take a dose of NAC, but also supplement that with some GSH. There are other forms of GSH out there as well, including suppositories, inhalable form and liposomal gsh (encapsulated gsh...readily absorbable in the gut). Hell you could even make your own nasal spray hehe.

One more thing...denatured whey protein contains a lot of Cystine, which is the oxidized form of cysteine, and is a better way to get cysteine. It is virtually non toxic(as opposed to cysteine) and is more readily available then the cysteine...

<a target=_blank class=ftalternatingbarlinklarge href="http://en.wikipedia.org/wiki/Cystine
">http://en.wikipedia.org/wiki/Cystine
</a>
"The free amino acid cysteine does not represent an ideal delivery system to the cell. It is potentially toxic and is easily catabolized spontaneously in the gastrointestinal tract and in the blood plasma. However, cysteine which is absorbed during digestion as cystine (two cysteine molecules linked by a disulfide bond) is more stable than the free amino acid cysteine. The disulfide bond is pepsin and trypsin-resistant (two important digestive enzymes in the stomach), but may be split by heat, low pH, and mechanical stress. Cystine travels safely through the GI tract and blood plasma and is promptly reduced to the two cysteine molecules upon cell entry."

A proven good source is something called immunocal...but it is expensive as hell.

<a target=_blank class=ftalternatingbarlinklarge href="http://www.immunocal.com/
">http://www.immunocal.com/
</a>
however, here is a much cheaper source. I am sure there are others out there...

<a target=_blank class=ftalternatingbarlinklarge href="http://www.lef.org/newshop/items/item00509.html
">http://www.lef.org/newshop/items/item00509.html
</a>
Hope that helps...

Kiel
 
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