Wow, I actually thought this would be a "lame" topic, but turned out pretty popular...and I found out I'm not the only one who gulped down nearly 20 at a time...then cut down according to my age!!
Laura (catboogie), when I referred to as "sick", it was in regards to the stomach or gastrointestinal, so as not to be confused with our other forms of feeling "sick".
This is personal opinion, but basically if I'm having stomach aches, poor bowel movements (loose or with too much oil), I usually would adjust my enzymes to match the hard work my digestion system needed for it. But, I'd also try and adjust my food intake to avoid the oily foods. As we've seen here, everyone has their degrees of complications, but I personally had problems from foods with too much oil, and would take extra enzymes for them (I don't take enzymes now, but there are a few supplements that will actually help)
The other form of "sick" would be having a lung infection, and taking the antibiotics (and/or vitamins) along with the enzymes, increasing the amount needed to take.
I couldn't take medication with milk, because, well, basically, I couldn't stand mixing milk with meds. (Besides, some meds were not supposed to be taken with dairy, so watch your warning labels!-public announcement-hehe!)
I've been able to take only one without anything to drink, and it was under rare circumstances, like being somewhere with nothing to drink, or in a hurry.