I was doing some research about alpha-1 antitrypsin deficiency--what has been considered a possible cause for my bronchiectasis--and looking at whether gene combos that cause variations in this "substance" are researched in people with CF. A1AT in layman's terms helps with repairing damage to lungs during infection.
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<br />I found a study of people with CF and with different gene combinations for A1AT--looking for amount of A1AT each person made and severity of pulmonary disease. The results of the study, and the reason I am (not) randomly posting it in this thread , were that:
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<br />A1AT genotype was not associated with severity of disease nor with amount of this good stuff made during an exacerbation...BMI was.
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<br />Keeping that weight on is so important.
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<br />FWIW 5'5" 118, an increase since starting to rock climb (indoors)
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<br /><a target=_blank class=ftalternatingbarlinklarge href="http://www.ncbi.nlm.nih.gov/pubmed/12689922">http://www.ncbi.nlm.nih.gov/pubmed/12689922</a>
<br />
<br />I found a study of people with CF and with different gene combinations for A1AT--looking for amount of A1AT each person made and severity of pulmonary disease. The results of the study, and the reason I am (not) randomly posting it in this thread , were that:
<br />
<br />A1AT genotype was not associated with severity of disease nor with amount of this good stuff made during an exacerbation...BMI was.
<br />
<br />Keeping that weight on is so important.
<br />
<br />FWIW 5'5" 118, an increase since starting to rock climb (indoors)
<br />
<br /><a target=_blank class=ftalternatingbarlinklarge href="http://www.ncbi.nlm.nih.gov/pubmed/12689922">http://www.ncbi.nlm.nih.gov/pubmed/12689922</a>