Now, I know this is just one article, but I found it really interesting, in france, they did research of CFers with class I /I or class II/I combinations. They found a much higher likelihood of severe pancreatic disease (which we knew), but the interestig thing was they found that people with a class one mutation were more likely to be colonized with pseudo. Interesting.
<a target=_blank class=ftalternatingbarlinklarge href="http://www.pslgroup.com/dg/214BBE.htm
">http://www.pslgroup.com/dg/214BBE.htm
</a>
Edited to add: I lied, there's more, this is the one I was looking for in my pile earlier. In Thorax, July of 2005, there was an article about genotype and pulmonary outcome. Here's what I found :
Seventy four patients were included in the study. Patients with genotype I-II/I-II had significantly lower current spirometric values (p < 0.001), greater loss of pulmonary function (p < 0.04), a higher proportion of end-stage lung disease (p < 0.001), a higher risk of suffering from moderate to severe lung disease (odds ratio 7.12 (95% CI 1.3 to 40.5)) and a lower probability of survival than patients with genotype I-II/III, I-II/IV and I-II/V (p < 0.001). CONCLUSIONS: The presence of class I or II mutations on both chromosomes is associated with worse respiratory disease and a lower probability of survival
So, what I always assumed was right, there is SOME tie between genotype and phenotype.
I only own the hard coppy of that article, but I gave you the stuff to look it up.
<a target=_blank class=ftalternatingbarlinklarge href="http://www.pslgroup.com/dg/214BBE.htm
">http://www.pslgroup.com/dg/214BBE.htm
</a>
Edited to add: I lied, there's more, this is the one I was looking for in my pile earlier. In Thorax, July of 2005, there was an article about genotype and pulmonary outcome. Here's what I found :
Seventy four patients were included in the study. Patients with genotype I-II/I-II had significantly lower current spirometric values (p < 0.001), greater loss of pulmonary function (p < 0.04), a higher proportion of end-stage lung disease (p < 0.001), a higher risk of suffering from moderate to severe lung disease (odds ratio 7.12 (95% CI 1.3 to 40.5)) and a lower probability of survival than patients with genotype I-II/III, I-II/IV and I-II/V (p < 0.001). CONCLUSIONS: The presence of class I or II mutations on both chromosomes is associated with worse respiratory disease and a lower probability of survival
So, what I always assumed was right, there is SOME tie between genotype and phenotype.
I only own the hard coppy of that article, but I gave you the stuff to look it up.