I agree also Jfarel. To me, saying different mutations have no affect on disease severity/progression, just seems stupid. I have only looked into my mutations lightly, but one of them, the G551D (I believe I read it somewhere) was said to lead to a partially functioning CFTR channel. My doctor also told me that this mutation is probably a big factor in me being 36 and having such good PFT's and general health. Gene expression occurs all the time with components in our diet. For example the soy isoflavone genistein has been shown to restore proper CFTR function associated with the G551D mutation (like i posted before on here). That right there proves that components in our diet can, and do turn genes off and on and can have positive or negative effects on our genome.
There is a ton to it though...Being compliant with care, hygiene, good doctors, diet, exercise, luck, not buying into everything your doctor wants to do to you...Tons of aspects associated with where each of us end up sans genetics. But I think genetics plays a big part.
There is a ton to it though...Being compliant with care, hygiene, good doctors, diet, exercise, luck, not buying into everything your doctor wants to do to you...Tons of aspects associated with where each of us end up sans genetics. But I think genetics plays a big part.