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<div class="MessageText_Container">My 2 daughters have the S1118F mutation. One is 17 and the other is 8. It seems to be a milder mutation were the chloride channel works 5-10% of the time. Both are pancreatic sufficient. I have found data on the internet were studies have been done on this mutation - specifically at Emory University in Atlanta. <br /><br />The studies at Emory show it is a gating mutation and it allows the chloride channel to work 5-10% of the time. My hope is that the VX-770 drug now being tested which was designed for the G551D mutation (also a gating mutation), will be effective for the S1118F mutation. The VX-770 seems to force the channel open. We'll have to wait and see if it is effective for S1118F.
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<div class="MessageText_Container">My 2 daughters have the S1118F mutation. One is 17 and the other is 8. It seems to be a milder mutation were the chloride channel works 5-10% of the time. Both are pancreatic sufficient. I have found data on the internet were studies have been done on this mutation - specifically at Emory University in Atlanta. <br /><br />The studies at Emory show it is a gating mutation and it allows the chloride channel to work 5-10% of the time. My hope is that the VX-770 drug now being tested which was designed for the G551D mutation (also a gating mutation), will be effective for the S1118F mutation. The VX-770 seems to force the channel open. We'll have to wait and see if it is effective for S1118F.
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