The problem with using prednisone to treat ABPA, is that it doesn't truly "treat" it. It only addresses the issue of the inflammation that is the allergic response. The fungus itself needs to be wiped out, and that is exceedingly difficult in CF. Additionally, the doctor may be deciding whether the prednisone is working based solely on how IgE numbers are responding. Again, this is not an ideal approach to treating ABPA.
An anti-fungal such as itraconozole, V-fend or sporanox are the best available options for getting close to reducing the mold growth. Unfortunately, these are very expensive, and insurance companies are loathe to fill these on a long-term basis.
Speaking strictly from the quality of life point of view, I opted for the sporanox and not the prednisone. I had so many side effects from the steroid alone, that it was a no-contest decision.
Read more about my experience with ABPA here:
<a target=_blank class=ftalternatingbarlinklarge href="http://livingwellwithcf.blogspot.com/search?q=aspergillus">Fungus Among Us (a blog entry)</a>
<a target=_blank class=ftalternatingbarlinklarge href="http://www.associatedcontent.com/article/78634/limiting_exposure_to_mold_in_the_home.html">Article on Mold Growth, CF and Allergies</a>
<a target=_blank class=ftalternatingbarlinklarge href="http://www.helium.com/tm/112521">ABPA Explained (some repeat info from the others)</a>
