Mild mutation and childwish

[Saskiaatje]

Yes, you all did explained enough about the genes a next child might have. Because of Englisch insn't my first language I think I'm not good in explaining what I mean. I'll try again...

So, a next child has 25% chance to get the exact same mutations my daughter might have: the DF 508 and a more rare one, which, according to the biopt they did is a mild one (says the doctor). What I want to know, is if the next child if it has the both mutations, will get the same results out of a sweattest or a biopt? Or is it possible a child with exect the same mutations will have worse results? I think I already know the answer, because on this forum I read storys about families who discovered three of there kids have CF, but they found that out when de 3rd one had symptoms and the other two never did.

My husband and I are making our minds up about prenatal testing. If it's sure a next child will also have a mild form like our daughter, we won't, if it can be a next child will be showing more symptoms with the same two mutations we might consider that. (but I don't think I could ever break up a pregnancy so I'm not sure what the use of prenatal testing would be then...)

 

[Saskiaatje]

Yes, you all did explained enough about the genes a next child might have. Because of Englisch insn't my first language I think I'm not good in explaining what I mean. I'll try again...

So, a next child has 25% chance to get the exact same mutations my daughter might have: the DF 508 and a more rare one, which, according to the biopt they did is a mild one (says the doctor). What I want to know, is if the next child if it has the both mutations, will get the same results out of a sweattest or a biopt? Or is it possible a child with exect the same mutations will have worse results? I think I already know the answer, because on this forum I read storys about families who discovered three of there kids have CF, but they found that out when de 3rd one had symptoms and the other two never did.

My husband and I are making our minds up about prenatal testing. If it's sure a next child will also have a mild form like our daughter, we won't, if it can be a next child will be showing more symptoms with the same two mutations we might consider that. (but I don't think I could ever break up a pregnancy so I'm not sure what the use of prenatal testing would be then...)

 

[Saskiaatje]

Yes, you all did explained enough about the genes a next child might have. Because of Englisch insn't my first language I think I'm not good in explaining what I mean. I'll try again...

So, a next child has 25% chance to get the exact same mutations my daughter might have: the DF 508 and a more rare one, which, according to the biopt they did is a mild one (says the doctor). What I want to know, is if the next child if it has the both mutations, will get the same results out of a sweattest or a biopt? Or is it possible a child with exect the same mutations will have worse results? I think I already know the answer, because on this forum I read storys about families who discovered three of there kids have CF, but they found that out when de 3rd one had symptoms and the other two never did.

My husband and I are making our minds up about prenatal testing. If it's sure a next child will also have a mild form like our daughter, we won't, if it can be a next child will be showing more symptoms with the same two mutations we might consider that. (but I don't think I could ever break up a pregnancy so I'm not sure what the use of prenatal testing would be then...)

 

[Saskiaatje]

Yes, you all did explained enough about the genes a next child might have. Because of Englisch insn't my first language I think I'm not good in explaining what I mean. I'll try again...

So, a next child has 25% chance to get the exact same mutations my daughter might have: the DF 508 and a more rare one, which, according to the biopt they did is a mild one (says the doctor). What I want to know, is if the next child if it has the both mutations, will get the same results out of a sweattest or a biopt? Or is it possible a child with exect the same mutations will have worse results? I think I already know the answer, because on this forum I read storys about families who discovered three of there kids have CF, but they found that out when de 3rd one had symptoms and the other two never did.

My husband and I are making our minds up about prenatal testing. If it's sure a next child will also have a mild form like our daughter, we won't, if it can be a next child will be showing more symptoms with the same two mutations we might consider that. (but I don't think I could ever break up a pregnancy so I'm not sure what the use of prenatal testing would be then...)

 

[Saskiaatje]

Yes, you all did explained enough about the genes a next child might have. Because of Englisch insn't my first language I think I'm not good in explaining what I mean. I'll try again...
<br />
<br />So, a next child has 25% chance to get the exact same mutations my daughter might have: the DF 508 and a more rare one, which, according to the biopt they did is a mild one (says the doctor). What I want to know, is if the next child if it has the both mutations, will get the same results out of a sweattest or a biopt? Or is it possible a child with exect the same mutations will have worse results? I think I already know the answer, because on this forum I read storys about families who discovered three of there kids have CF, but they found that out when de 3rd one had symptoms and the other two never did.
<br />
<br />My husband and I are making our minds up about prenatal testing. If it's sure a next child will also have a mild form like our daughter, we won't, if it can be a next child will be showing more symptoms with the same two mutations we might consider that. (but I don't think I could ever break up a pregnancy so I'm not sure what the use of prenatal testing would be then...)

 

[JazzysMom]

IF there are 2 mutations (DF508 & the unidentified one) then there is a 25% chance another child will have CF, 50% chance of just being a carrier of a gene & 25% chance of having NOTHING.

IF the child gets both genes, any results (sweat test, biopsy or how the health goes) can be completely different. They might start out the same and change over time. They might be the same from the beginning & remain that way. One might be extremely sick and the other "fine". Even with meds, compliance, the same environment & care.....the part that can change things is luck.

Sadly <img src="i/expressions/face-icon-small-sad.gif" border="0"> if it was easier to know what to expect, it would be easier to make decisions about more kids.

 

[JazzysMom]

IF there are 2 mutations (DF508 & the unidentified one) then there is a 25% chance another child will have CF, 50% chance of just being a carrier of a gene & 25% chance of having NOTHING.

IF the child gets both genes, any results (sweat test, biopsy or how the health goes) can be completely different. They might start out the same and change over time. They might be the same from the beginning & remain that way. One might be extremely sick and the other "fine". Even with meds, compliance, the same environment & care.....the part that can change things is luck.

Sadly <img src="i/expressions/face-icon-small-sad.gif" border="0"> if it was easier to know what to expect, it would be easier to make decisions about more kids.

 

[JazzysMom]

IF there are 2 mutations (DF508 & the unidentified one) then there is a 25% chance another child will have CF, 50% chance of just being a carrier of a gene & 25% chance of having NOTHING.

IF the child gets both genes, any results (sweat test, biopsy or how the health goes) can be completely different. They might start out the same and change over time. They might be the same from the beginning & remain that way. One might be extremely sick and the other "fine". Even with meds, compliance, the same environment & care.....the part that can change things is luck.

Sadly <img src="i/expressions/face-icon-small-sad.gif" border="0"> if it was easier to know what to expect, it would be easier to make decisions about more kids.

 

[JazzysMom]

IF there are 2 mutations (DF508 & the unidentified one) then there is a 25% chance another child will have CF, 50% chance of just being a carrier of a gene & 25% chance of having NOTHING.

IF the child gets both genes, any results (sweat test, biopsy or how the health goes) can be completely different. They might start out the same and change over time. They might be the same from the beginning & remain that way. One might be extremely sick and the other "fine". Even with meds, compliance, the same environment & care.....the part that can change things is luck.

Sadly <img src="i/expressions/face-icon-small-sad.gif" border="0"> if it was easier to know what to expect, it would be easier to make decisions about more kids.

 

[JazzysMom]

IF there are 2 mutations (DF508 & the unidentified one) then there is a 25% chance another child will have CF, 50% chance of just being a carrier of a gene & 25% chance of having NOTHING.
<br />
<br />IF the child gets both genes, any results (sweat test, biopsy or how the health goes) can be completely different. They might start out the same and change over time. They might be the same from the beginning & remain that way. One might be extremely sick and the other "fine". Even with meds, compliance, the same environment & care.....the part that can change things is luck.
<br />
<br />Sadly <img src="i/expressions/face-icon-small-sad.gif" border="0"> if it was easier to know what to expect, it would be easier to make decisions about more kids.

 

[Alyssa]

Yep, you've got it -- you have a 25% change of having another child with the same two mutations. But you do not have any guarantee that their symptoms and overall health will be exactly the same over time. It is a guessing game. Nobody can tell you for sure how the symptoms will or will not progress.

Take for example my kids - daughter showed symptoms at 5 years old, son showed symptoms at 18 years old.

Yes, general statements and assumptions can sometimes be gleaned from what gene mutations a person has, but every person and every case is so individual and different you just cannot say for sure.

 

[Alyssa]

Yep, you've got it -- you have a 25% change of having another child with the same two mutations. But you do not have any guarantee that their symptoms and overall health will be exactly the same over time. It is a guessing game. Nobody can tell you for sure how the symptoms will or will not progress.

Take for example my kids - daughter showed symptoms at 5 years old, son showed symptoms at 18 years old.

Yes, general statements and assumptions can sometimes be gleaned from what gene mutations a person has, but every person and every case is so individual and different you just cannot say for sure.

 

[Alyssa]

Yep, you've got it -- you have a 25% change of having another child with the same two mutations. But you do not have any guarantee that their symptoms and overall health will be exactly the same over time. It is a guessing game. Nobody can tell you for sure how the symptoms will or will not progress.

Take for example my kids - daughter showed symptoms at 5 years old, son showed symptoms at 18 years old.

Yes, general statements and assumptions can sometimes be gleaned from what gene mutations a person has, but every person and every case is so individual and different you just cannot say for sure.

 

[Alyssa]

Yep, you've got it -- you have a 25% change of having another child with the same two mutations. But you do not have any guarantee that their symptoms and overall health will be exactly the same over time. It is a guessing game. Nobody can tell you for sure how the symptoms will or will not progress.

Take for example my kids - daughter showed symptoms at 5 years old, son showed symptoms at 18 years old.

Yes, general statements and assumptions can sometimes be gleaned from what gene mutations a person has, but every person and every case is so individual and different you just cannot say for sure.

 

[Alyssa]

Yep, you've got it -- you have a 25% change of having another child with the same two mutations. But you do not have any guarantee that their symptoms and overall health will be exactly the same over time. It is a guessing game. Nobody can tell you for sure how the symptoms will or will not progress.
<br />
<br />Take for example my kids - daughter showed symptoms at 5 years old, son showed symptoms at 18 years old.
<br />
<br />Yes, general statements and assumptions can sometimes be gleaned from what gene mutations a person has, but every person and every case is so individual and different you just cannot say for sure.

 

[Marjolein]

Hi Saskiaatje, it's me, Marjolein from the Dutch forums.

I was pointed to your thread via a PM from someone who noticed you are from the Netherlands too.

I'm glad you found this place and hope you can get some contact with other parents that are or have been in the same situation that you are now.
I see Melissa, Alyssa and Heather have already replied to you a few times, they are the best!

When you have any question on how to translate something into English, just post it here or sent me a PM and I'll try to translate it.

 

[Marjolein]

Hi Saskiaatje, it's me, Marjolein from the Dutch forums.

I was pointed to your thread via a PM from someone who noticed you are from the Netherlands too.

I'm glad you found this place and hope you can get some contact with other parents that are or have been in the same situation that you are now.
I see Melissa, Alyssa and Heather have already replied to you a few times, they are the best!

When you have any question on how to translate something into English, just post it here or sent me a PM and I'll try to translate it.

 

[Marjolein]

Hi Saskiaatje, it's me, Marjolein from the Dutch forums.

I was pointed to your thread via a PM from someone who noticed you are from the Netherlands too.

I'm glad you found this place and hope you can get some contact with other parents that are or have been in the same situation that you are now.
I see Melissa, Alyssa and Heather have already replied to you a few times, they are the best!

When you have any question on how to translate something into English, just post it here or sent me a PM and I'll try to translate it.

 

[Marjolein]

Hi Saskiaatje, it's me, Marjolein from the Dutch forums.

I was pointed to your thread via a PM from someone who noticed you are from the Netherlands too.

I'm glad you found this place and hope you can get some contact with other parents that are or have been in the same situation that you are now.
I see Melissa, Alyssa and Heather have already replied to you a few times, they are the best!

When you have any question on how to translate something into English, just post it here or sent me a PM and I'll try to translate it.

 

[Marjolein]

Hi Saskiaatje, it's me, Marjolein from the Dutch forums.
<br />
<br />I was pointed to your thread via a PM from someone who noticed you are from the Netherlands too.
<br />
<br />I'm glad you found this place and hope you can get some contact with other parents that are or have been in the same situation that you are now.
<br />I see Melissa, Alyssa and Heather have already replied to you a few times, they are the best!
<br />
<br />When you have any question on how to translate something into English, just post it here or sent me a PM and I'll try to translate it.