<br>I had all conventional CF GI drugs stop working for me gradually since Feb 2009. Enzymes, miralax, golytely, etc just stopped working. It was a mystery and miserable. I used MILK OF MAGNESIA instead and that helped some. But in Aug 2011 I was diagnosed withsmallBowel cancer- thatwas the culprit. I had surgery to resect the tumor and am on preventative chemo for six months- not that bad- nohair loss or nausea. All my symptoms resolved after the surgery and miralax works great now. I had 2CT scans of the abdomen in 2010 and 2011and they didn't see the tumor (4cm)because it was buried in my small bowel. I would suggest that if you are really constipated and experience a change in bowel symptoms including not responding to conventional meds, ask your doc for some GI scans. I read that CF folks and CF carriers have a 6.5% increased risk in bowel cancer so symptoms should not be ignored or passed as just "CF". My mom had bowel cancer due to her CF gene 15 years ago and is fine. Also I was very anemic, which is a sign of internal bleeding due to a tumor, and that was ignored as related to CF too. The chance that your problem is cancer is REALLY Low but I just want to spread the word and put that on people's radar. Good luck! <br>ANA STENZEL , age 39 , CF, lung transplant
