mycobacterium avium complex

Hi,<br>
<br>
Funny you should ask: I just started treatment for MAC, again, about 3
weeks ago. I actually posted on here about MAC, but did not get as
many replies as you have. Culturing mycobacterium avium one time is
not a good way to diagnose MAC. As some people have replied to you, it
is everywhere in the environment and not everything we happen to culture
is actually an infection. I don't know if you posted prior to this
about health problems, but your symptoms would be a greater indicator of
need to treat than your culture (in my personal opinion and
experience). Typical diagnosis involves a CT scan of lungs and at
least 2 positive cultures, as well as symptoms of the infection. For people with CF, at least, one needs to consider the benefits of treatment versus not treating....<br>
<br>
In my case I started treating before, couldn't handle the drugs, stopped
after 6 months, and gradually started feeling like crap again. Now I
am doing 3x weekly (Did daily before) rifampin, enthambutol, and
azithromycin (sub for clarithro). Rifampin is typically the drug that is extremely hard for people to tolerate. I believe there are alternatives,
which I will seek if I can't handle these, but if you end up pursuing
treatment, you should definitely look at all the options and take into
account how you feel if you do take these medications.<br><br>The first time before I treated I had night sweats, felt like crap, and actually coughed up blood twice (never had done that before, never since). This time I also had general feeling of crappiness, gradual weight loss of about 10-15lbs over a period of 1.5 years (this was over the entire period of MAC not just the second time and I was already thin), and a lung function decline of 16% in one year (102%-86%). Throughout all of this I have had a terrible nagging cough that is barely tolerable. Typically it is initially hard to tell if the symptoms are this or other things since feeling like crap and coughing could be many other things. <br>
<br>
Notably I have CFRD as you do, and typically high lung function. I have
heard that (not sure if there is ANY truth to this) people with CF with
higher lung functioning seem to get this more than those with
lower...... If you do end up treating and want to talk, let me know. <br>
<br>
<br>
Sarah~
 
Hi,<br>
<br>
Funny you should ask: I just started treatment for MAC, again, about 3
weeks ago. I actually posted on here about MAC, but did not get as
many replies as you have. Culturing mycobacterium avium one time is
not a good way to diagnose MAC. As some people have replied to you, it
is everywhere in the environment and not everything we happen to culture
is actually an infection. I don't know if you posted prior to this
about health problems, but your symptoms would be a greater indicator of
need to treat than your culture (in my personal opinion and
experience). Typical diagnosis involves a CT scan of lungs and at
least 2 positive cultures, as well as symptoms of the infection. For people with CF, at least, one needs to consider the benefits of treatment versus not treating....<br>
<br>
In my case I started treating before, couldn't handle the drugs, stopped
after 6 months, and gradually started feeling like crap again. Now I
am doing 3x weekly (Did daily before) rifampin, enthambutol, and
azithromycin (sub for clarithro). Rifampin is typically the drug that is extremely hard for people to tolerate. I believe there are alternatives,
which I will seek if I can't handle these, but if you end up pursuing
treatment, you should definitely look at all the options and take into
account how you feel if you do take these medications.<br><br>The first time before I treated I had night sweats, felt like crap, and actually coughed up blood twice (never had done that before, never since). This time I also had general feeling of crappiness, gradual weight loss of about 10-15lbs over a period of 1.5 years (this was over the entire period of MAC not just the second time and I was already thin), and a lung function decline of 16% in one year (102%-86%). Throughout all of this I have had a terrible nagging cough that is barely tolerable. Typically it is initially hard to tell if the symptoms are this or other things since feeling like crap and coughing could be many other things. <br>
<br>
Notably I have CFRD as you do, and typically high lung function. I have
heard that (not sure if there is ANY truth to this) people with CF with
higher lung functioning seem to get this more than those with
lower...... If you do end up treating and want to talk, let me know. <br>
<br>
<br>
Sarah~
 
thanks SOOOOOOO much sarah! :] i was thinking that if i cultured it only once it wasnt a positive sign i had it..as well as when i cultured b cepatia once but never again. i generally have higher lung function too.
 
thanks SOOOOOOO much sarah! :] i was thinking that if i cultured it only once it wasnt a positive sign i had it..as well as when i cultured b cepatia once but never again. i generally have higher lung function too.
 
thanks SOOOOOOO much sarah! :] i was thinking that if i cultured it only once it wasnt a positive sign i had it..as well as when i cultured b cepatia once but never again. i generally have higher lung function too.
 

kwcf50

New member
I was happy to stumble upon this as have ongoing concerns.

I am 49 with CF, FEV1=44%. About 4 years ago I had a bad year with 3 hospitalizations, fevers, hemoptsis, really low energy. My Doc sent sputum in for "further testing" and called me a month after a hospitalization to tell me I had cultured MAC and that before he would treat me for it I would need to have 3 positive cultures. Of course, right away, I googled it and saw that the #1 symptom is night sweats which I had been having SEVERELY changing clothes 2-3 times a night as was drenched. I had thought it was pre-menapause or some such thing. Anyway the following two times we sent in for culturing the result was inconclusive or negative so we've proceeded to ignore it. I do feel oddly feverish most of the time but running no fever and have night sweats perioudically. I'm not sure what all this means or if I should pursue having more cultures done/or treatment of some kind. My Doc seemed reluctant to do any treatment as he said the treatment can cause worse problems.

From what I'm reading most people here seem to have pursued treatment. Other than MAC I have PA which is resistant to most oral (Cipro is slightly responsive), resistant to Cayston now, will be participating in a study for an older antibiotic that has been reformulated for inhalatioin, Mpex Levaquin. Other than that I can fall back on Colisten and back to IVs which I prefer to avoid.

Any advice on whether I should push for more info/testing/treatment on MAC or ignore it would be appreciated. I'm not sure what "letting it go untreated" means long-term.

Best,
Kay
49 with CF from Illinois
 

kwcf50

New member
I was happy to stumble upon this as have ongoing concerns.

I am 49 with CF, FEV1=44%. About 4 years ago I had a bad year with 3 hospitalizations, fevers, hemoptsis, really low energy. My Doc sent sputum in for "further testing" and called me a month after a hospitalization to tell me I had cultured MAC and that before he would treat me for it I would need to have 3 positive cultures. Of course, right away, I googled it and saw that the #1 symptom is night sweats which I had been having SEVERELY changing clothes 2-3 times a night as was drenched. I had thought it was pre-menapause or some such thing. Anyway the following two times we sent in for culturing the result was inconclusive or negative so we've proceeded to ignore it. I do feel oddly feverish most of the time but running no fever and have night sweats perioudically. I'm not sure what all this means or if I should pursue having more cultures done/or treatment of some kind. My Doc seemed reluctant to do any treatment as he said the treatment can cause worse problems.

From what I'm reading most people here seem to have pursued treatment. Other than MAC I have PA which is resistant to most oral (Cipro is slightly responsive), resistant to Cayston now, will be participating in a study for an older antibiotic that has been reformulated for inhalatioin, Mpex Levaquin. Other than that I can fall back on Colisten and back to IVs which I prefer to avoid.

Any advice on whether I should push for more info/testing/treatment on MAC or ignore it would be appreciated. I'm not sure what "letting it go untreated" means long-term.

Best,
Kay
49 with CF from Illinois
 

kwcf50

New member
I was happy to stumble upon this as have ongoing concerns.
<br />
<br />I am 49 with CF, FEV1=44%. About 4 years ago I had a bad year with 3 hospitalizations, fevers, hemoptsis, really low energy. My Doc sent sputum in for "further testing" and called me a month after a hospitalization to tell me I had cultured MAC and that before he would treat me for it I would need to have 3 positive cultures. Of course, right away, I googled it and saw that the #1 symptom is night sweats which I had been having SEVERELY changing clothes 2-3 times a night as was drenched. I had thought it was pre-menapause or some such thing. Anyway the following two times we sent in for culturing the result was inconclusive or negative so we've proceeded to ignore it. I do feel oddly feverish most of the time but running no fever and have night sweats perioudically. I'm not sure what all this means or if I should pursue having more cultures done/or treatment of some kind. My Doc seemed reluctant to do any treatment as he said the treatment can cause worse problems.
<br />
<br />From what I'm reading most people here seem to have pursued treatment. Other than MAC I have PA which is resistant to most oral (Cipro is slightly responsive), resistant to Cayston now, will be participating in a study for an older antibiotic that has been reformulated for inhalatioin, Mpex Levaquin. Other than that I can fall back on Colisten and back to IVs which I prefer to avoid.
<br />
<br />Any advice on whether I should push for more info/testing/treatment on MAC or ignore it would be appreciated. I'm not sure what "letting it go untreated" means long-term.
<br />
<br />Best,
<br />Kay
<br />49 with CF from Illinois
 
D

Deb

Guest
Kay, I am also from IL. Small town south of Champaign-Urbana. Where are you?

I am still doing CT scans at least every 6 months since a have a history of m-avium and now also abscessus. I have posted this before, but I would recommend that anyone with concerns contact National Jewish in Denver. Even though they did not treat my m-avium 20 years ago I think the fact that we didn't treat is why they ended up removing my left lung. They are much more aggressive about treating these days.
 
D

Deb

Guest
Kay, I am also from IL. Small town south of Champaign-Urbana. Where are you?

I am still doing CT scans at least every 6 months since a have a history of m-avium and now also abscessus. I have posted this before, but I would recommend that anyone with concerns contact National Jewish in Denver. Even though they did not treat my m-avium 20 years ago I think the fact that we didn't treat is why they ended up removing my left lung. They are much more aggressive about treating these days.
 
D

Deb

Guest
Kay, I am also from IL. Small town south of Champaign-Urbana. Where are you?
<br />
<br />I am still doing CT scans at least every 6 months since a have a history of m-avium and now also abscessus. I have posted this before, but I would recommend that anyone with concerns contact National Jewish in Denver. Even though they did not treat my m-avium 20 years ago I think the fact that we didn't treat is why they ended up removing my left lung. They are much more aggressive about treating these days.
 
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