I like my Mobilaire. Like someone said for Tobi its under 20 minutes, right around 16-18 minutes at 25 psi. The cool thing is you can adjust the psi. For drugs like duoneb and pulmozyme you can crank it up to 50 psi if you wish and get them done in less then 5 minutes each. For Tobi you suppose to keep it at 25 psi.