New with Questions

S

shannon

New member
Hello,<br>
<br>
I have had no luck googling & am anxious for some answers.
 Maybe someone here can help us.<br>
<br>
My husband and I have been trying to have a baby, and recently he
submitted a sperm sample for analysis.  It came back with a
zero sperm count.  He has had chronic lung problems his whole
life, which he always thought was asthma.  Now we are
wondering if he has CF because of the zero sperm count.  <br>
<br>
We have a horrible HMO and cannot get in to see a doctor for this
until mid November, but he has a urologist appt on 11/2 for the
sperm issue.  As part of this appt, they will test him to see
if he is a carrier for CF.  We want to learn as much as
possible from that appointment since we'll have to wait so long for
the other one.  So here are my questions:<br>
<br>
1.  If his results indicate that he is NOT a carrier for CF,
does this mean he absolutely does not have CF?<br>
<br>
2.  What kind of testing do we need to ask for at the second
appt to determine whether he has CF?  He is 34, if that
makes a difference.<br>
<br>
Thanks so much for your help!
 
S

shannon

New member
Hello,<br>
<br>
I have had no luck googling & am anxious for some answers.
 Maybe someone here can help us.<br>
<br>
My husband and I have been trying to have a baby, and recently he
submitted a sperm sample for analysis.  It came back with a
zero sperm count.  He has had chronic lung problems his whole
life, which he always thought was asthma.  Now we are
wondering if he has CF because of the zero sperm count.  <br>
<br>
We have a horrible HMO and cannot get in to see a doctor for this
until mid November, but he has a urologist appt on 11/2 for the
sperm issue.  As part of this appt, they will test him to see
if he is a carrier for CF.  We want to learn as much as
possible from that appointment since we'll have to wait so long for
the other one.  So here are my questions:<br>
<br>
1.  If his results indicate that he is NOT a carrier for CF,
does this mean he absolutely does not have CF?<br>
<br>
2.  What kind of testing do we need to ask for at the second
appt to determine whether he has CF?  He is 34, if that
makes a difference.<br>
<br>
Thanks so much for your help!
 
S

shannon

New member
Hello,<br>
<br>
I have had no luck googling & am anxious for some answers.
 Maybe someone here can help us.<br>
<br>
My husband and I have been trying to have a baby, and recently he
submitted a sperm sample for analysis.  It came back with a
zero sperm count.  He has had chronic lung problems his whole
life, which he always thought was asthma.  Now we are
wondering if he has CF because of the zero sperm count.  <br>
<br>
We have a horrible HMO and cannot get in to see a doctor for this
until mid November, but he has a urologist appt on 11/2 for the
sperm issue.  As part of this appt, they will test him to see
if he is a carrier for CF.  We want to learn as much as
possible from that appointment since we'll have to wait so long for
the other one.  So here are my questions:<br>
<br>
1.  If his results indicate that he is NOT a carrier for CF,
does this mean he absolutely does not have CF?<br>
<br>
2.  What kind of testing do we need to ask for at the second
appt to determine whether he has CF?  He is 34, if that
makes a difference.<br>
<br>
Thanks so much for your help!
 
R

Rutgersnyy

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>shannon</b></i>

Hello,



I have had no luck googling & am anxious for some answers.
 Maybe someone here can help us.



My husband and I have been trying to have a baby, and recently he
submitted a sperm sample for analysis.  It came back with a
zero sperm count.  He has had chronic lung problems his whole
life, which he always thought was asthma.  Now we are
wondering if he has CF because of the zero sperm count.  



We have a horrible HMO and cannot get in to see a doctor for this
until mid November, but he has a urologist appt on 11/2 for the
sperm issue.  As part of this appt, they will test him to see
if he is a carrier for CF.  We want to learn as much as
possible from that appointment since we'll have to wait so long for
the other one.  So here are my questions:



1.  If his results indicate that he is NOT a carrier for CF,
does this mean he absolutely does not have CF?



2.  What kind of testing do we need to ask for at the second
appt to determine whether he has CF?  He is 34, if that
makes a difference.



Thanks so much for your help!</end quote></div>


If he is not a carrier, he definitely does not have CF.

You can still have kids w/o having sperm in the ejaculate. He will have to have Sperm retrieval and then in vitro.
 
R

Rutgersnyy

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>shannon</b></i>

Hello,



I have had no luck googling & am anxious for some answers.
 Maybe someone here can help us.



My husband and I have been trying to have a baby, and recently he
submitted a sperm sample for analysis.  It came back with a
zero sperm count.  He has had chronic lung problems his whole
life, which he always thought was asthma.  Now we are
wondering if he has CF because of the zero sperm count.  



We have a horrible HMO and cannot get in to see a doctor for this
until mid November, but he has a urologist appt on 11/2 for the
sperm issue.  As part of this appt, they will test him to see
if he is a carrier for CF.  We want to learn as much as
possible from that appointment since we'll have to wait so long for
the other one.  So here are my questions:



1.  If his results indicate that he is NOT a carrier for CF,
does this mean he absolutely does not have CF?



2.  What kind of testing do we need to ask for at the second
appt to determine whether he has CF?  He is 34, if that
makes a difference.



Thanks so much for your help!</end quote></div>


If he is not a carrier, he definitely does not have CF.

You can still have kids w/o having sperm in the ejaculate. He will have to have Sperm retrieval and then in vitro.
 
R

Rutgersnyy

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>shannon</b></i>

Hello,



I have had no luck googling & am anxious for some answers.
 Maybe someone here can help us.



My husband and I have been trying to have a baby, and recently he
submitted a sperm sample for analysis.  It came back with a
zero sperm count.  He has had chronic lung problems his whole
life, which he always thought was asthma.  Now we are
wondering if he has CF because of the zero sperm count.  



We have a horrible HMO and cannot get in to see a doctor for this
until mid November, but he has a urologist appt on 11/2 for the
sperm issue.  As part of this appt, they will test him to see
if he is a carrier for CF.  We want to learn as much as
possible from that appointment since we'll have to wait so long for
the other one.  So here are my questions:



1.  If his results indicate that he is NOT a carrier for CF,
does this mean he absolutely does not have CF?



2.  What kind of testing do we need to ask for at the second
appt to determine whether he has CF?  He is 34, if that
makes a difference.



Thanks so much for your help!</end quote></div>


If he is not a carrier, he definitely does not have CF.

You can still have kids w/o having sperm in the ejaculate. He will have to have Sperm retrieval and then in vitro.
 
S

shannon

New member
Thanks Rutgersnyy.  I have also heard about the IVF option
when there is no sperm in the ejaculate.  However we are now
more concerned with getting his diagnosis one way or the other for
CF.  That is great to know that the carrier test could give us
some insight.<br>
<br>
Anyone else have advice on what kind of diagnostic testing to ask
for to determine whether he has CF?  He was tested twice as a
young child, but it was negative both times... but my MIL doesn't
know what kind of test they did or how specific they were.  We
just want to know as soon as we can.<br>
<br>
Sorry these are simplistic questions, I just haven't had much luck
googling this.   Thanks so much.  <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
S

shannon

New member
Thanks Rutgersnyy.  I have also heard about the IVF option
when there is no sperm in the ejaculate.  However we are now
more concerned with getting his diagnosis one way or the other for
CF.  That is great to know that the carrier test could give us
some insight.<br>
<br>
Anyone else have advice on what kind of diagnostic testing to ask
for to determine whether he has CF?  He was tested twice as a
young child, but it was negative both times... but my MIL doesn't
know what kind of test they did or how specific they were.  We
just want to know as soon as we can.<br>
<br>
Sorry these are simplistic questions, I just haven't had much luck
googling this.   Thanks so much.  <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
S

shannon

New member
Thanks Rutgersnyy.  I have also heard about the IVF option
when there is no sperm in the ejaculate.  However we are now
more concerned with getting his diagnosis one way or the other for
CF.  That is great to know that the carrier test could give us
some insight.<br>
<br>
Anyone else have advice on what kind of diagnostic testing to ask
for to determine whether he has CF?  He was tested twice as a
young child, but it was negative both times... but my MIL doesn't
know what kind of test they did or how specific they were.  We
just want to know as soon as we can.<br>
<br>
Sorry these are simplistic questions, I just haven't had much luck
googling this.   Thanks so much.  <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
F

Fruity

New member
Hi there.<br>
<br>
Let me say first that I extend my best wishes for you and your
husband and welcome to the site.<br>
<br>
To answer your questions, in general, to be diagnosed with CF,
you have to have two CF genes in your genome. There are a few cases
of people having CF symptoms and only being a carrier (having one
gene in the genome) but the majority of all people with CF have two
genes. There are many many variations of the genes that can come
together to cause CF, so a blood test must be done to check for
which two it is. I do not know if the test for if you are a carrier
is the same as the test to see if you have CF. However, the two
most common tests are a sweat chloride test and a blood test. The
sweat chloride test has been around since CF was recognized as a
disease, if I'm not mistaken (someone can feel free to correct me),
and is most likely what your husband was tested with when he
was a child. I was tested when I was a child with the sweat test
and I did not get diagnosed either. It wasn't until the genetic
code was broken and they could test for the genes in my blood that
I was diagnosed at age 14. It used to be that most CF was
diagnosed before age one, but late diagnosis is becoming more and
more common since the blood testing capability, so your husband is
not alone. As far as I know, the blood test for diagnostic
purposes is just called a genetic mutation analysis.<br>
<br>
I hope this helps, and I wish you comfort, patience and peace.<br>
<br>
Be well, and feel free to keep asking questions as they come
along.<br>
<br>
Ceci
 
F

Fruity

New member
Hi there.<br>
<br>
Let me say first that I extend my best wishes for you and your
husband and welcome to the site.<br>
<br>
To answer your questions, in general, to be diagnosed with CF,
you have to have two CF genes in your genome. There are a few cases
of people having CF symptoms and only being a carrier (having one
gene in the genome) but the majority of all people with CF have two
genes. There are many many variations of the genes that can come
together to cause CF, so a blood test must be done to check for
which two it is. I do not know if the test for if you are a carrier
is the same as the test to see if you have CF. However, the two
most common tests are a sweat chloride test and a blood test. The
sweat chloride test has been around since CF was recognized as a
disease, if I'm not mistaken (someone can feel free to correct me),
and is most likely what your husband was tested with when he
was a child. I was tested when I was a child with the sweat test
and I did not get diagnosed either. It wasn't until the genetic
code was broken and they could test for the genes in my blood that
I was diagnosed at age 14. It used to be that most CF was
diagnosed before age one, but late diagnosis is becoming more and
more common since the blood testing capability, so your husband is
not alone. As far as I know, the blood test for diagnostic
purposes is just called a genetic mutation analysis.<br>
<br>
I hope this helps, and I wish you comfort, patience and peace.<br>
<br>
Be well, and feel free to keep asking questions as they come
along.<br>
<br>
Ceci
 
F

Fruity

New member
Hi there.<br>
<br>
Let me say first that I extend my best wishes for you and your
husband and welcome to the site.<br>
<br>
To answer your questions, in general, to be diagnosed with CF,
you have to have two CF genes in your genome. There are a few cases
of people having CF symptoms and only being a carrier (having one
gene in the genome) but the majority of all people with CF have two
genes. There are many many variations of the genes that can come
together to cause CF, so a blood test must be done to check for
which two it is. I do not know if the test for if you are a carrier
is the same as the test to see if you have CF. However, the two
most common tests are a sweat chloride test and a blood test. The
sweat chloride test has been around since CF was recognized as a
disease, if I'm not mistaken (someone can feel free to correct me),
and is most likely what your husband was tested with when he
was a child. I was tested when I was a child with the sweat test
and I did not get diagnosed either. It wasn't until the genetic
code was broken and they could test for the genes in my blood that
I was diagnosed at age 14. It used to be that most CF was
diagnosed before age one, but late diagnosis is becoming more and
more common since the blood testing capability, so your husband is
not alone. As far as I know, the blood test for diagnostic
purposes is just called a genetic mutation analysis.<br>
<br>
I hope this helps, and I wish you comfort, patience and peace.<br>
<br>
Be well, and feel free to keep asking questions as they come
along.<br>
<br>
Ceci
 
N

NoExcuses

New member
If he was tested as a kid, he was probably sweat tested if it was prior to 1989. This was when the gene was discovered. So gene testing prior to 1989 would not have been possible.

Obviously genetic tests are more acurate than sweat tests....but even genetic testing isn't perfect.

Keep us posted on how things turn out.
 
N

NoExcuses

New member
If he was tested as a kid, he was probably sweat tested if it was prior to 1989. This was when the gene was discovered. So gene testing prior to 1989 would not have been possible.

Obviously genetic tests are more acurate than sweat tests....but even genetic testing isn't perfect.

Keep us posted on how things turn out.
 
N

NoExcuses

New member
If he was tested as a kid, he was probably sweat tested if it was prior to 1989. This was when the gene was discovered. So gene testing prior to 1989 would not have been possible.

Obviously genetic tests are more acurate than sweat tests....but even genetic testing isn't perfect.

Keep us posted on how things turn out.
 
S

shannon

New member
Thanks so much Fruity & Amy.  I'll be sure we get a blood
test instead of the sweat test, since that sounds more accurate.
 He probably was sweat tested before.  I'll keep you
posted, and thanks again for helping me out.  
 
S

shannon

New member
Thanks so much Fruity & Amy.  I'll be sure we get a blood
test instead of the sweat test, since that sounds more accurate.
 He probably was sweat tested before.  I'll keep you
posted, and thanks again for helping me out.  
 
S

shannon

New member
Thanks so much Fruity & Amy.  I'll be sure we get a blood
test instead of the sweat test, since that sounds more accurate.
 He probably was sweat tested before.  I'll keep you
posted, and thanks again for helping me out.  
 
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